Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma
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Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma. / Stolearenco, Veronica; Namini, Martin R.J.; Hasselager, Siri S.; Gluud, Maria; Buus, Terkild B.; Willerslev-Olsen, Andreas; Ødum, Niels; Krejsgaard, Thorbjørn.
In: Frontiers in Cell and Developmental Biology, Vol. 8, 851, 2020.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma
AU - Stolearenco, Veronica
AU - Namini, Martin R.J.
AU - Hasselager, Siri S.
AU - Gluud, Maria
AU - Buus, Terkild B.
AU - Willerslev-Olsen, Andreas
AU - Ødum, Niels
AU - Krejsgaard, Thorbjørn
PY - 2020
Y1 - 2020
N2 - Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaques covering a limited area of the skin and normally follows an indolent course. However, in a subset of patients the cutaneous lesions develop into tumors and the malignant T cells may spread to the lymphatic system, blood and internal organs with fatal consequences. Despite intensive research, the mechanisms driving disease progression remain incompletely understood. While most studies have focused on cancer cell-intrinsic oncogenesis, such as genetic and epigenetic events driving malignant transformation and disease progression, an increasing body of evidence shows that the interplay between malignant T cells and non-malignant cells plays a crucial role. Here, we outline some of the emerging mechanisms by which tumor, stromal and epidermal interactions may contribute to the progression of CTCL with particular emphasis on the crosstalk between fibroblasts, keratinocytes and malignant T cells.
AB - Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaques covering a limited area of the skin and normally follows an indolent course. However, in a subset of patients the cutaneous lesions develop into tumors and the malignant T cells may spread to the lymphatic system, blood and internal organs with fatal consequences. Despite intensive research, the mechanisms driving disease progression remain incompletely understood. While most studies have focused on cancer cell-intrinsic oncogenesis, such as genetic and epigenetic events driving malignant transformation and disease progression, an increasing body of evidence shows that the interplay between malignant T cells and non-malignant cells plays a crucial role. Here, we outline some of the emerging mechanisms by which tumor, stromal and epidermal interactions may contribute to the progression of CTCL with particular emphasis on the crosstalk between fibroblasts, keratinocytes and malignant T cells.
KW - cutaneous T-cell lymphoma
KW - fibroblasts
KW - keratinocytes
KW - malignant T cells
KW - tumor microenvironment
U2 - 10.3389/fcell.2020.00851
DO - 10.3389/fcell.2020.00851
M3 - Review
C2 - 33015047
AN - SCOPUS:85091227377
VL - 8
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 851
ER -
ID: 249771440