T Cell Biology and Skin Inflammation
The aim of the Bonefeld Group is to characterize and understand novel pathways and molecules in T cell activation and differentiation in inflammatory skin diseases. Thereby we hope to provide the basis for developing novel means to prevent and treat inflammatory skin diseases.
Our primary interest is T cell biology and inflammatory skin diseases. We focus on the role of filaggrin and other molecules in T cell development and function, vitamin D as a regulator of activation and differentiation of T cells, T cell responses during inflammatory skin diseases, crosstalk between T cells, antigen presenting cells and keratinocytes, and the role of skin-resident memory T cells versus systemic memory T cells during skin inflammation.
“People with skin conditions often suffer from strongly diminished quality of life. By obtaining deeper knowledge of the central cells and molecules causing skin diseases, we hope to provide the basis for new innovative therapies and prevention of inflammatory skin diseases”, says Group Leader Charlotte Menné Bonefeld.
In our group, we have extensive experience in cutting-edged analyses of the adaptive immune system in both humans and mice. We have established advanced in vitro studies of human and mouse T cells including isolation of specific T cell subsets, multi-colour flow cytometric analysis and single cell separation and sequencing.
We have established models for inflammatory skin diseases, and we have developed a range of highly advanced methods to isolate and analyse single cells from the epidermis and dermis. We have an extensive collaboration with researchers at the University Hospitals and a strong international network.
Group members
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