Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma
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- Staphylococcus aureus alpha toxin inhibits CD8 T cell mediated killing of cancer cells in cutaneous T cell lymphoma
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Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and Sézary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.
Original language | English |
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Article number | 1751561 |
Journal | OncoImmunology |
Volume | 9 |
Issue number | 1 |
Number of pages | 9 |
ISSN | 2162-4011 |
DOIs | |
Publication status | Published - 2020 |
- Alpha-toxin, CD8 T cells, CTCL, cytotoxicity, Staphylococcus aureus
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