Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells
Research output: Contribution to journal › Journal article › Research › peer-review
The suppressors of cytokine signalling (SOCS) proteins comprise a newly identified family of negative feedback regulators of cytokine signalling. SOCS expression is differentially induced upon cytokine stimulation in different cell types. Here we show that interferon-alpha (IFNalpha) is a potent inducer of SOCS expression in human T cells, as high expression of CIS, SOCS-1, SOCS-2, and SOCS-3 was detectable after IFNalpha stimulation. After 4 h of stimulation, CIS, SOCS-1, and SOCS-3 expression had returned to baseline levels, whereas SOCS-2 expression had not declined. In contrast, after IL-2 induction neither CIS, SOCS-1, nor SOCS-2 expression levels declined after 6 h. In conclusion, we provide the first evidence that IFNalpha induces SOCS expression in human T cells. Moreover, we show that IFNalpha and IL-2 induce distinct patterns of expression kinetics, suggesting that dynamic changes in cytokine sensitivity might be mediated via induction of SOCS expression with different kinetics in T cells.
Original language | English |
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Journal | Experimental and Clinical Immunogenetics |
Volume | 18 |
Issue number | 2 |
Pages (from-to) | 80-5 |
Number of pages | 5 |
ISSN | 0254-9670 |
Publication status | Published - 2001 |
Bibliographical note
Keywords: CD4-Positive T-Lymphocytes; Carrier Proteins; Cell Line; DNA-Binding Proteins; Gene Expression; Humans; Interferon-alpha; Interleukin-2; Intracellular Signaling Peptides and Proteins; Proteins; Repressor Proteins; Signal Transduction; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors
ID: 8544817