Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells. / Brender, C; Nielsen, M; Röpke, C; Nissen, M H; Svejgaard, A; Billestrup, N; Geisler, C; Ødum, N.

In: Experimental and Clinical Immunogenetics, Vol. 18, No. 2, 2001, p. 80-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brender, C, Nielsen, M, Röpke, C, Nissen, MH, Svejgaard, A, Billestrup, N, Geisler, C & Ødum, N 2001, 'Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells', Experimental and Clinical Immunogenetics, vol. 18, no. 2, pp. 80-5.

APA

Brender, C., Nielsen, M., Röpke, C., Nissen, M. H., Svejgaard, A., Billestrup, N., Geisler, C., & Ødum, N. (2001). Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells. Experimental and Clinical Immunogenetics, 18(2), 80-5.

Vancouver

Brender C, Nielsen M, Röpke C, Nissen MH, Svejgaard A, Billestrup N et al. Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells. Experimental and Clinical Immunogenetics. 2001;18(2):80-5.

Author

Brender, C ; Nielsen, M ; Röpke, C ; Nissen, M H ; Svejgaard, A ; Billestrup, N ; Geisler, C ; Ødum, N. / Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells. In: Experimental and Clinical Immunogenetics. 2001 ; Vol. 18, No. 2. pp. 80-5.

Bibtex

@article{7ab023d0b0a111ddb538000ea68e967b,
title = "Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells",
abstract = "The suppressors of cytokine signalling (SOCS) proteins comprise a newly identified family of negative feedback regulators of cytokine signalling. SOCS expression is differentially induced upon cytokine stimulation in different cell types. Here we show that interferon-alpha (IFNalpha) is a potent inducer of SOCS expression in human T cells, as high expression of CIS, SOCS-1, SOCS-2, and SOCS-3 was detectable after IFNalpha stimulation. After 4 h of stimulation, CIS, SOCS-1, and SOCS-3 expression had returned to baseline levels, whereas SOCS-2 expression had not declined. In contrast, after IL-2 induction neither CIS, SOCS-1, nor SOCS-2 expression levels declined after 6 h. In conclusion, we provide the first evidence that IFNalpha induces SOCS expression in human T cells. Moreover, we show that IFNalpha and IL-2 induce distinct patterns of expression kinetics, suggesting that dynamic changes in cytokine sensitivity might be mediated via induction of SOCS expression with different kinetics in T cells.",
author = "C Brender and M Nielsen and C R{\"o}pke and Nissen, {M H} and A Svejgaard and N Billestrup and C Geisler and N {\O}dum",
note = "Keywords: CD4-Positive T-Lymphocytes; Carrier Proteins; Cell Line; DNA-Binding Proteins; Gene Expression; Humans; Interferon-alpha; Interleukin-2; Intracellular Signaling Peptides and Proteins; Proteins; Repressor Proteins; Signal Transduction; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors",
year = "2001",
language = "English",
volume = "18",
pages = "80--5",
journal = "Experimental and Clinical Immunogenetics",
issn = "0254-9670",
publisher = "S Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells

AU - Brender, C

AU - Nielsen, M

AU - Röpke, C

AU - Nissen, M H

AU - Svejgaard, A

AU - Billestrup, N

AU - Geisler, C

AU - Ødum, N

N1 - Keywords: CD4-Positive T-Lymphocytes; Carrier Proteins; Cell Line; DNA-Binding Proteins; Gene Expression; Humans; Interferon-alpha; Interleukin-2; Intracellular Signaling Peptides and Proteins; Proteins; Repressor Proteins; Signal Transduction; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors

PY - 2001

Y1 - 2001

N2 - The suppressors of cytokine signalling (SOCS) proteins comprise a newly identified family of negative feedback regulators of cytokine signalling. SOCS expression is differentially induced upon cytokine stimulation in different cell types. Here we show that interferon-alpha (IFNalpha) is a potent inducer of SOCS expression in human T cells, as high expression of CIS, SOCS-1, SOCS-2, and SOCS-3 was detectable after IFNalpha stimulation. After 4 h of stimulation, CIS, SOCS-1, and SOCS-3 expression had returned to baseline levels, whereas SOCS-2 expression had not declined. In contrast, after IL-2 induction neither CIS, SOCS-1, nor SOCS-2 expression levels declined after 6 h. In conclusion, we provide the first evidence that IFNalpha induces SOCS expression in human T cells. Moreover, we show that IFNalpha and IL-2 induce distinct patterns of expression kinetics, suggesting that dynamic changes in cytokine sensitivity might be mediated via induction of SOCS expression with different kinetics in T cells.

AB - The suppressors of cytokine signalling (SOCS) proteins comprise a newly identified family of negative feedback regulators of cytokine signalling. SOCS expression is differentially induced upon cytokine stimulation in different cell types. Here we show that interferon-alpha (IFNalpha) is a potent inducer of SOCS expression in human T cells, as high expression of CIS, SOCS-1, SOCS-2, and SOCS-3 was detectable after IFNalpha stimulation. After 4 h of stimulation, CIS, SOCS-1, and SOCS-3 expression had returned to baseline levels, whereas SOCS-2 expression had not declined. In contrast, after IL-2 induction neither CIS, SOCS-1, nor SOCS-2 expression levels declined after 6 h. In conclusion, we provide the first evidence that IFNalpha induces SOCS expression in human T cells. Moreover, we show that IFNalpha and IL-2 induce distinct patterns of expression kinetics, suggesting that dynamic changes in cytokine sensitivity might be mediated via induction of SOCS expression with different kinetics in T cells.

M3 - Journal article

C2 - 11340296

VL - 18

SP - 80

EP - 85

JO - Experimental and Clinical Immunogenetics

JF - Experimental and Clinical Immunogenetics

SN - 0254-9670

IS - 2

ER -

ID: 8544817