Carsten Geisler

Carsten Geisler

Professor

Member of:


    1. 2001
    2. Published

      Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a

      Brockdorff, J. L., Gu, H., Mustelin, T., Kaltoft, K., Geisler, Carsten, Röpke, C. & Ødum, Niels, 2001, In: Experimental and Clinical Immunogenetics. 18, 2, p. 86-95 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells

      Brender, C., Nielsen, M., Röpke, C., Nissen, M. H., Svejgaard, A., Billestrup, N., Geisler, Carsten & Ødum, Niels, 2001, In: Experimental and Clinical Immunogenetics. 18, 2, p. 80-5 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Protein phosphatase 2A isotypes regulate cell surface expression of the T cell receptor

      Lauritsen, J. P. H., Bonefeld, Charlotte Menne, Kastrup, J., Dietrich, J. & Geisler, Carsten, 2001, In: Experimental and Clinical Immunogenetics. 18, 1, p. 24-33 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens

      Andersen, P. S., Geisler, Carsten, Buus, Søren, Mariuzza, R. A. & Karjalainen, K., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33452-7 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain

      Bonefeld, Charlotte Menne, Lauritsen, J. P. H., Dietrich, J., Kastrup, J., Wegener, A. K., Andersen, P. S., Odum, N. & Geisler, Carsten, 2001, In: Scandinavian Journal of Immunology. 53, 2, p. 176-83 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. 2000
    8. Published

      Amino acid substitutions in the melanoma antigen recognized by T cell 1 peptide modulate cytokine responses in melanoma-specific T cells

      Nielsen, M. B., Kirkin, A. F., Loftus, D., Nissen, Mogens Holst, Rivoltini, L., Zeuthen, J., Geisler, Carsten & Odum, N., 2000, In: Journal of Immunotherapy. 23, 4, p. 405-11 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Ceramide-induced TCR up-regulation

      Bonefeld, Charlotte Menne, Lauritsen, J. P. H., Dietrich, J., Kastrup, J., Wegener, A. M., Ødum, Niels & Geisler, Carsten, 2000, In: Journal of Immunology. 165, 6, p. 3065-72 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Lck is involved in interleukin-2 induced proliferation but not cell survival in human T cells through a MAP kinase-independent pathway

      Brockdorff, J., Nielsen, M., Kaltoft, K., Mustelin, T., Röpke, C., Svejaard, A., Geisler, Carsten & Odum, N., 2000, In: European Cytokine Network. 11, 2, p. 225-31 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Recruitment of SHP-1 protein tyrosine phosphatase and signalling by a chimeric T-cell receptor-killer inhibitory receptor

      Bartels, Mette Damkjær & Geisler, Carsten, 2000, In: Scandinavian Journal of Immunology. 51, 6, p. 557-64 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation

      Kastrup, J., Lauritsen, J. P. H., Bonefeld, Charlotte Menne, Dietrich, J. & Geisler, Carsten, 2000, In: Scandinavian Journal of Immunology. 51, 5, p. 491-6 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      beta2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase

      Lauritsen, J. P. H., Bonefeld, Charlotte Menne, Kastrup, J., Dietrich, J., Ødum, Niels & Geisler, Carsten, 2000, In: BBA General Subjects. 1497, 3, p. 297-307 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. 1999
    15. Published

      Cutting edge: TCR stimulation by antibody and bacterial superantigen induces Stat3 activation in human T cells

      Gerwien, J., Nielsen, M., Labuda, T., Nissen, M. H., Svejgaard, A., Geisler, Carsten, Röpke, C. & Odum, N., 1999, In: Journal of Immunology. 163, 4, p. 1742-5 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

      Nielsen, M., Kaestel, C. G., Eriksen, K. W., Woetmann, Anders , Stokkedal, T., Kaltoft, K., Geisler, Carsten, Röpke, C. & Odum, N., 1999, In: Leukemia. 13, 5, p. 735-8 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3

      Woetmann, Anders , Nielsen, M., Christensen, S. T., Brockdorff, J., Kaltoft, K., Engel, A. M., Skov, S., Brender, C., Geisler, Carsten, Svejgaard, A., Rygaard, J., Leick, V. & Odum, N., 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, 19, p. 10620-5 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      TCR¿ is transported to and retained in the Golgi apparatus independently of other TCR chains: implications for TCR assembly

      Dietrich, J., Kastrup, J., Lauritsen, J. P. H., Bonefeld, Charlotte Menne, von Bülow, F. & Geisler, Carsten, 1999, In: European Journal of Immunology. 29, 5, p. 1719-28 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. 1998
    20. Published

      Interleukin-2 induces beta2-integrin-dependent signal transduction involving the focal adhesion kinase-related protein B (fakB)

      Brockdorff, J., Kanner, S. B., Nielsen, M., Borregaard, N., Geisler, Carsten, Svejgaard, A. & Odum, N., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, 12, p. 6959-64 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Leucine-based receptor sorting motifs are dependent on the spacing relative to the plasma membrane

      Geisler, Carsten, Dietrich, J., Nielsen, B. L., Kastrup, J., Lauritsen, J. P. H., Ødum, Niels & Bartels, Mette Damkjær, 1998, In: Journal of Biological Chemistry. 273, 33, p. 21316-23 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      MHC class II ligation induces CD58 (LFA-3)-mediated adhesion in human T cells

      Nielsen, M., Gerwien, J., Geisler, Carsten, Röpke, C., Svejgaard, A. & Odum, N., 1998, In: Experimental and Clinical Immunogenetics. 15, 2, p. 61-8 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART1(27-35)

      Loftus, D. J., Squarcina, P., Nielsen, M. B., Geisler, Carsten, Castelli, C., Odum, N., Appella, E., Parmiani, G. & Rivoltini, L., 1998, In: Cancer Research. 58, 11, p. 2433-9 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Recognition of melanoma-derived antigens by CTL: possible mechanisms involved in down-regulating anti-tumor T-cell reactivity

      Rivoltini, L., Loftus, D. J., Squarcina, P., Castelli, C., Rini, F., Arienti, F., Belli, F., Marincola, F. M., Geisler, Carsten, Borsatti, A., Appella, E. & Parmiani, G., 1998, In: Critical Reviews in Immunology. 18, 1-2, p. 55-63 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines

      Nielsen, M. B., Odum, N., Gerwien, J., Svejgaard, A., Bendtzen, K., Bregentholt, S., Röpke, C., Geisler, Carsten, Dohlsten, M. & Kaltoft, K., 1998, In: HLA. 52, 6, p. 530-8 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Staphylococcus enterotoxin A modulates interleukin 15-induced signaling and mitogenesis in human T cells

      Gerwien, J., Kaltoft, K., Nielsen, M., Nielsen, M. B., Svejgaard, A., Geisler, Carsten, Röpke, C. & Odum, N., 1998, In: HLA. 51, 2, p. 164-73 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      T cell receptor zeta allows stable expression of receptors containing the CD3gamma leucine-based receptor-sorting motif

      Dietrich, J. & Geisler, Carsten, 1998, In: Journal of Biological Chemistry. 273, 41, p. 26281-4 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      TCR alpha beta chains associate with the plasma membrane independently of CD3 and TCR zeta chains in murine primary T cells

      Zhang, J., Salojin, K., Gao, J. X., Cameron, M., Geisler, Carsten & Delovitch, T. L., 1998, In: Journal of Immunology. 161, 6, p. 2930-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      The phosphorylation state of CD3gamma influences T cell responsiveness and controls T cell receptor cycling

      Dietrich, J., Bäckström, T., Lauritsen, J. P., Kastrup, J., Bartels, Mette Damkjær, von Bülow, F., Palmer, E. & Geisler, Carsten, 1998, In: Journal of Biological Chemistry. 273, 37, p. 24232-8 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      The role of caspase 3 and BclxL in the action of interleukin 7 (IL-7): a survival factor in activated human T cells

      Amos, C. L., Woetmann, Anders , Nielsen, M., Geisler, Carsten, Odum, N., Brown, B. L. & Dobson, P. R., 1998, In: Cytokine. 10, 9, p. 662-8 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Two distinct pathways exist for down-regulation of the TCR

      Lauritsen, J. P., Bartels, Mette Damkjær, Dietrich, J., Kastrup, J., Odum, N. & Geisler, Carsten, 1998, In: Journal of Immunology. 161, 1, p. 260-7 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. 1997
    33. Published

      Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

      Nielsen, M., Kaltoft, K., Nordahl, M., Röpke, C., Geisler, Carsten, Mustelin, T., Dobson, P., Svejgaard, A. & Odum, N., 1997, In: Proceedings of the National Academy of Science of the United States of America. 94, 13, p. 6764-9 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Interleukin 2 induces a transient downregulation of protein phosphatase 1 and 2A activity in human T cells

      Brockdorff, J., Nielsen, M., Dobson, P., Geisler, Carsten, Röpke, C., Svejgaard, A. & Odum, N., 1997, In: HLA. 49, 3 Pt 1, p. 228-35 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Protein phosphatase 2A plays a critical role in interleukin-2-induced beta 2-integrin dependent homotypic adhesion in human CD4+ T cell lines

      Brockdorff, J., Nielsen, M., Svejgaard, A., Dobson, P., Röpke, C., Geisler, Carsten & Odum, N., 1997, In: Cytokine. 9, 5, p. 333-9 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Regulation and function of the CD3¿ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro

      Dietrich, J., Kastrup, J., Nielsen, B. L., Odum, N. & Geisler, Carsten, 1997, In: Journal of Cell Biology. 138, 2, p. 271-81 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. 1996
    38. Published

      IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with induction of adhesion, but not mitogenesis

      Nielsen, M., Svejgaard, A., Skov, Søren, Dobson, P., Bendtzen, K., Geisler, Carsten & Odum, N., 1996, In: Journal of Immunology. 157, 12, p. 5350-8 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Molecular characterization of the di-leucine-based internalization motif of the T cell receptor

      Dietrich, J., Hou, X., Wegener, A. M., Pedersen, L. O., Odum, N. & Geisler, Carsten, 1996, In: Journal of Biological Chemistry. 271, 19, p. 11441-8 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Role of CD3 gamma in T cell receptor assembly

      Dietrich, J., Neisig, A., Hou, X., Wegener, A. M., Gajhede, Michael & Geisler, Carsten, 1996, In: Journal of Cell Biology. 132, 3, p. 299-310 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      The cytoplasmic tail of FcgammaRIIIAalpha is involved in signaling by the low affinity receptor for immunoglobulin G

      Hou, X., Dietrich, J. & Geisler, Carsten, 1996, In: Journal of Biological Chemistry. 271, 37, p. 22815-22 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. 1995
    43. Published

      Distinct domains of the CD3-gamma chain are involved in surface expression and function of the T cell antigen receptor

      Wegener, A. M., Hou, X., Dietrich, J. & Geisler, Carsten, 1995, In: Journal of Biological Chemistry. 270, 9, p. 4675-80 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      The T cell receptor. Structural and functional studies

      Geisler, Carsten, 1995, In: Danish Medical Bulletin. 42, 4, p. 342-57 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. 1994
    46. Published

      A highly conserved phenylalanine in the alpha, beta-T cell receptor (TCR) constant region determines the integrity of TCR/CD3 complexes

      Caspar-Bauguil, S., Arnaud, J., Huchenq, A., Hein, W. R., Geisler, Carsten & Rubin, B., 1994, In: Scandinavian Journal of Immunology. 40, 3, p. 323-36 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor

      Dietrich, J., Hou, X., Wegener, A. M. & Geisler, Carsten, 1994, In: EMBO Journal. 13, 9, p. 2156-66 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Functionally important amino acids in the TCR revealed by immunoselection of membrane TCR-negative T cells

      Caspar-Bauguil, S., Arnaud, J., Gouaillard, C., Hou, X., Geisler, Carsten & Rubin, B., 1994, In: Journal of Immunology. 152, 11, p. 5288-98 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Structure of the T cell receptor in a Ti alpha V beta 2, alpha V beta 8-positive T cell line

      Hou, X., Dietrich, J., Kuhlmann, J., Wegener, A. M. & Geisler, Carsten, 1994, In: European Journal of Immunology. 24, 5, p. 1228-33 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. 1993
    51. Published

      Assembly of the T-cell antigen receptor. Participation of the CD3 omega chain

      Neisig, A., Vangsted, A., Zeuthen, J. & Geisler, Carsten, 1993, In: Journal of Immunology. 151, 2, p. 870-9 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      Biosynthesis of Tcr-alpha, beta and Tcr-gamma, delta/CD3 complexes

      Bauguil-Caspar, S., Arnaud, J., Kuhlmann, J., Geisler, Carsten & Rubin, B., 1993, In: Immunodeficiency. 4, 1-4, p. 113-6 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. Published

      Characterization of T cell receptor assembly and expression in a Ti gamma delta-positive cell line

      Kuhlmann, J., Caspar-Bauguil, S., Geisler, Carsten & Rubin, B., 1993, In: European Journal of Immunology. 23, 2, p. 487-93 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    54. Published

      Induction of CD3 delta epsilon omega by phorbol 12-myristate 13-acetate

      Vangsted, A., Neisig, A., Wallin, H., Zeuthen, J. & Geisler, Carsten, 1993, In: European Journal of Immunology. 23, 6, p. 1351-7 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    55. Published

      Structure of the T-cell receptor in a Ti alpha beta, Ti gamma delta double positive T-cell line

      Kuhlmann, J. & Geisler, Carsten, 1993, In: Scandinavian Journal of Immunology. 37, 2, p. 271-5 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    56. Published

      T-cell activation. V. Anti-major histocompatibility complex class I antibody-induced activation and clonal abortion in Jurkat T-leukaemic cells

      Claesson, Mogens Helweg, Dissing, Steen, Tscherning, T. & Geisler, Carsten, 1993, In: Immunology. 78, 3, p. 444-8 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    57. 1992
    58. Published

      Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression

      Geisler, Carsten, 1992, In: Journal of Immunology. 148, 8, p. 2437-45 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    59. Published

      Structural mutations of C-domains in members of the Ig superfamily. Consequences for the interactions between the T cell antigen receptor and the zeta 2 homodimer

      Geisler, Carsten, Rubin, B., Caspar-Bauguil, S., Champagne, E., Vangsted, A., Hou, X. & Gajhede, Michael, 1992, In: Journal of Immunology. 148, 11, p. 3469-77 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    60. Published

      The indispensable CD2-CD3 molecules: a key to T-cell differentiation and functional activation

      Rubin, B., Geisler, Carsten, Caspar, S. & Arnaud, J., 1992, In: Scandinavian Journal of Immunology. 36, 1, p. 1-6 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    ID: 10043