MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes

Research output: Contribution to journal › Journal article › Research › peer-review

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MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes. / Šahmatova, Liisi; Tankov, Stoyan; Prans, Ele; Aab, Alar; Hermann, Helen; Reemann, Paula; Pihlap, Maire; Karelson, Maire; Abram, Kristi; Kisand, Kai; Kingo, Külli; Rebane, Ana.

In: Acta Dermato-Venereologica, Vol. 96, No. 6, 09.2016, p. 742-747.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Šahmatova, L, Tankov, S, Prans, E, Aab, A, Hermann, H, Reemann, P, Pihlap, M, Karelson, M, Abram, K, Kisand, K, Kingo, K & Rebane, A 2016, 'MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes', Acta Dermato-Venereologica, vol. 96, no. 6, pp. 742-747. https://doi.org/10.2340/00015555-2394

APA

Šahmatova, L., Tankov, S., Prans, E., Aab, A., Hermann, H., Reemann, P., Pihlap, M., Karelson, M., Abram, K., Kisand, K., Kingo, K., & Rebane, A. (2016). MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes. Acta Dermato-Venereologica, 96(6), 742-747. https://doi.org/10.2340/00015555-2394

Vancouver

Šahmatova L, Tankov S, Prans E, Aab A, Hermann H, Reemann P et al. MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes. Acta Dermato-Venereologica. 2016 Sep;96(6):742-747. https://doi.org/10.2340/00015555-2394

Author

Šahmatova, Liisi ; Tankov, Stoyan ; Prans, Ele ; Aab, Alar ; Hermann, Helen ; Reemann, Paula ; Pihlap, Maire ; Karelson, Maire ; Abram, Kristi ; Kisand, Kai ; Kingo, Külli ; Rebane, Ana. / MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes. In: Acta Dermato-Venereologica. 2016 ; Vol. 96, No. 6. pp. 742-747.

Bibtex

@article{1b3962c7247746259100e9f60bd0dec7,
title = "MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes",
abstract = "Little is known about the functions of microRNAs (miRNAs) in skin pigmentation disorders. The aim of this study was to investigate the expression and potential role of miRNAs in vitiligo. Of 12 studied miRNAs with proven functions in cell proliferation, differentiation, immune responses and melanogenesis, miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found to be decreased in the skin of patients with vitiligo. Combined pathway and target analysis revealed melanogenesis-associated targets for miR-99b, miR-125b, miR-155 and miR-199a-3p. In situ hybridization analysis demonstrated increased expression of miR-155 in the epidermis of patients with vitiligo. Correspondingly, miR-155 was induced by vitiligoassociated cytokines in human primary melanocytes and keratinocytes. When overexpressed, miR-155 inhibited the expression of melanogenesis-associated genes and altered interferon-regulated genes in melanocytes and keratinocytes. In conclusion, this study demonstrates that the expression of miRNAs is dysregulated in the skin of patients with vitiligo and suggests that miR-155 contributes to the pathogenesis of vitiligo.",
keywords = "Keratinocytes, Melanocytes, MiRNA, Skin, Vitiligo",
author = "Liisi {\v S}ahmatova and Stoyan Tankov and Ele Prans and Alar Aab and Helen Hermann and Paula Reemann and Maire Pihlap and Maire Karelson and Kristi Abram and Kai Kisand and K{\"u}lli Kingo and Ana Rebane",
note = "Funding Information: This work was supported by personal research funds PUT177 and PUT214, an institutional research grant IUT2-2 from the Estonian Research Council, European Regional Fund with the Archimedes Foundation and EU structural assistance grants SARMP12219T and SARBS12096T. Publisher Copyright: {\textcopyright} 2016 The Authors.",
year = "2016",
month = sep,
doi = "10.2340/00015555-2394",
language = "English",
volume = "96",
pages = "742--747",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "6",

}

RIS

TY - JOUR

T1 - MicroRNA-155 is dysregulated in the skin of patients with vitiligo and inhibits melanogenesis-associated genes in melanocytes and keratinocytes

AU - Šahmatova, Liisi

AU - Tankov, Stoyan

AU - Prans, Ele

AU - Aab, Alar

AU - Hermann, Helen

AU - Reemann, Paula

AU - Pihlap, Maire

AU - Karelson, Maire

AU - Abram, Kristi

AU - Kisand, Kai

AU - Kingo, Külli

AU - Rebane, Ana

N1 - Funding Information: This work was supported by personal research funds PUT177 and PUT214, an institutional research grant IUT2-2 from the Estonian Research Council, European Regional Fund with the Archimedes Foundation and EU structural assistance grants SARMP12219T and SARBS12096T. Publisher Copyright: © 2016 The Authors.

PY - 2016/9

Y1 - 2016/9

N2 - Little is known about the functions of microRNAs (miRNAs) in skin pigmentation disorders. The aim of this study was to investigate the expression and potential role of miRNAs in vitiligo. Of 12 studied miRNAs with proven functions in cell proliferation, differentiation, immune responses and melanogenesis, miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found to be decreased in the skin of patients with vitiligo. Combined pathway and target analysis revealed melanogenesis-associated targets for miR-99b, miR-125b, miR-155 and miR-199a-3p. In situ hybridization analysis demonstrated increased expression of miR-155 in the epidermis of patients with vitiligo. Correspondingly, miR-155 was induced by vitiligoassociated cytokines in human primary melanocytes and keratinocytes. When overexpressed, miR-155 inhibited the expression of melanogenesis-associated genes and altered interferon-regulated genes in melanocytes and keratinocytes. In conclusion, this study demonstrates that the expression of miRNAs is dysregulated in the skin of patients with vitiligo and suggests that miR-155 contributes to the pathogenesis of vitiligo.

AB - Little is known about the functions of microRNAs (miRNAs) in skin pigmentation disorders. The aim of this study was to investigate the expression and potential role of miRNAs in vitiligo. Of 12 studied miRNAs with proven functions in cell proliferation, differentiation, immune responses and melanogenesis, miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found to be decreased in the skin of patients with vitiligo. Combined pathway and target analysis revealed melanogenesis-associated targets for miR-99b, miR-125b, miR-155 and miR-199a-3p. In situ hybridization analysis demonstrated increased expression of miR-155 in the epidermis of patients with vitiligo. Correspondingly, miR-155 was induced by vitiligoassociated cytokines in human primary melanocytes and keratinocytes. When overexpressed, miR-155 inhibited the expression of melanogenesis-associated genes and altered interferon-regulated genes in melanocytes and keratinocytes. In conclusion, this study demonstrates that the expression of miRNAs is dysregulated in the skin of patients with vitiligo and suggests that miR-155 contributes to the pathogenesis of vitiligo.

KW - Keratinocytes

KW - Melanocytes

KW - MiRNA

KW - Skin

KW - Vitiligo

UR - http://www.scopus.com/inward/record.url?scp=84983064963&partnerID=8YFLogxK

U2 - 10.2340/00015555-2394

DO - 10.2340/00015555-2394

M3 - Journal article

C2 - 26941046

AN - SCOPUS:84983064963

VL - 96

SP - 742

EP - 747

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 6

ER -

ID: 315464263