Molecular Immunology and Inflammation

Selected publications

• Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KVM, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M (2018). Small-molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 37(17): pii:e99372.

• Hrdinka M and Gyrd-Hansen M (2017). The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation. Mol Cell 68(2): 265-280.

• Elliott PR, Leske D, Hrdinka M, Bagola K, Fiil BK, McLaughlin SH, Wagstaff J, Volkmar N, Christianson JC, Kessler BM, Freund SM, Komander D, Gyrd-Hansen M (2016). SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Mol Cell 63(6):990-1005.

• Damgaard RB, Fiil BK, Speckmann C, Yabal M, Stadt Uz, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M (2013). Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signaling. EMBO Mol Med 5(8):1278-95.

• Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M (2013). OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling. Mol Cell 50(6): 818-30.

• Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M (2012). The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 46(6): 746-58.