Transmembrane signalling via HLA-DR molecules on T cells from a Sezary T-cell leukaemia line
Research output: Contribution to journal › Journal article › Research › peer-review
The human Sezary T-cell leukaemia line, HUT.78, represents a population of activated T cells, i.e. they are HLA-DR+ and IL-2R+. We have analysed the capacity of HUT.78 cells (1) to stimulate HLA-DR-specific T-cell lines or clones and (2) to be induced to synthesize IL-2 by anti-HLA-DR monoclonal antibodies. The results of our experiments show that HLA-DR molecules on HUT.78 cells can stimulate at least one HLA-DR-specific T-cell clone and can act as transmembrane signal transmitters.
Original language | English |
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Journal | Scandinavian Journal of Immunology |
Volume | 32 |
Issue number | 6 |
Pages (from-to) | 731-5 |
Number of pages | 4 |
ISSN | 0300-9475 |
Publication status | Published - 1990 |
Bibliographical note
Keywords: Antibodies, Monoclonal; Antigens, CD; Antigens, CD3; Antigens, Differentiation, T-Lymphocyte; Cells, Cultured; Cross-Linking Reagents; Gene Expression Regulation, Neoplastic; HLA-DR Antigens; Humans; Interleukin-2; Receptors, Antigen, T-Cell; Sezary Syndrome; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured
ID: 8546274