Role of B-cells in mycosis fungoides
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- Role of B-cells in Mycosis Fungoides
Final published version, 3.25 MB, PDF document
Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. The inflammatory microenvironment in mycosis fungoides is complex. There is accumulating evidence that the neoplastic T-cells take control of the microenvironment and thereby promote their own expansion by suppressing cellular immunity. B-cells have proved to be upregulated in large-cell transformed mycosis fungoides, and could potentially play a role in disease progression. To investigate the presence of B-cells in mycosis fungoides compared with controls, this study analysed 85 formalin-fixed and paraffin-embedded mycosis fungoides biopsies. MS4A1 gene expression was significantly upregulated in mycosis fungoides compared with controls (p < 0.0001) and further upregulated in disease progression, (p = 0.001). Digital quantification of PAX5+/ CD20+ cells confirmed the increased presence of Bcells in mycosis fungoides compared with controls. No co-labelling of CD3/CD20 was observed in the neoplastic T-cells. This study found a significantly increased presence of B-cells in the tumour-associated microenvironment in mycosis fungoides. These findings could potentially lead to new treatment strategies for mycosis fungoides.
Original language | English |
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Article number | adv00413 |
Journal | Acta Dermato-Venereologica |
Volume | 101 |
Issue number | 3 |
ISSN | 0001-5555 |
DOIs | |
Publication status | Published - 2021 |
- B-cells, Cutaneous t-cell lymphoma, Mycosis fungoides, Tumour microenvironment
Research areas
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