Role of B-cells in mycosis fungoides
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Role of B-cells in mycosis fungoides. / Nielsen, Pia Rude; Eriksen, Jens Ole; Sørensen, Mia Dahl; Wehkamp, Ulrike; Lindahl, Lise Maria; Bzorek, Michael; Iversen, Lars; Woetman, Anders; Ødum, Niels; Litman, Thomas; Gjerdrum, Lise Mette Rahbek.
In: Acta Dermato-Venereologica, Vol. 101, No. 3, adv00413, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Role of B-cells in mycosis fungoides
AU - Nielsen, Pia Rude
AU - Eriksen, Jens Ole
AU - Sørensen, Mia Dahl
AU - Wehkamp, Ulrike
AU - Lindahl, Lise Maria
AU - Bzorek, Michael
AU - Iversen, Lars
AU - Woetman, Anders
AU - Ødum, Niels
AU - Litman, Thomas
AU - Gjerdrum, Lise Mette Rahbek
PY - 2021
Y1 - 2021
N2 - Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. The inflammatory microenvironment in mycosis fungoides is complex. There is accumulating evidence that the neoplastic T-cells take control of the microenvironment and thereby promote their own expansion by suppressing cellular immunity. B-cells have proved to be upregulated in large-cell transformed mycosis fungoides, and could potentially play a role in disease progression. To investigate the presence of B-cells in mycosis fungoides compared with controls, this study analysed 85 formalin-fixed and paraffin-embedded mycosis fungoides biopsies. MS4A1 gene expression was significantly upregulated in mycosis fungoides compared with controls (p < 0.0001) and further upregulated in disease progression, (p = 0.001). Digital quantification of PAX5+/ CD20+ cells confirmed the increased presence of Bcells in mycosis fungoides compared with controls. No co-labelling of CD3/CD20 was observed in the neoplastic T-cells. This study found a significantly increased presence of B-cells in the tumour-associated microenvironment in mycosis fungoides. These findings could potentially lead to new treatment strategies for mycosis fungoides.
AB - Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. The inflammatory microenvironment in mycosis fungoides is complex. There is accumulating evidence that the neoplastic T-cells take control of the microenvironment and thereby promote their own expansion by suppressing cellular immunity. B-cells have proved to be upregulated in large-cell transformed mycosis fungoides, and could potentially play a role in disease progression. To investigate the presence of B-cells in mycosis fungoides compared with controls, this study analysed 85 formalin-fixed and paraffin-embedded mycosis fungoides biopsies. MS4A1 gene expression was significantly upregulated in mycosis fungoides compared with controls (p < 0.0001) and further upregulated in disease progression, (p = 0.001). Digital quantification of PAX5+/ CD20+ cells confirmed the increased presence of Bcells in mycosis fungoides compared with controls. No co-labelling of CD3/CD20 was observed in the neoplastic T-cells. This study found a significantly increased presence of B-cells in the tumour-associated microenvironment in mycosis fungoides. These findings could potentially lead to new treatment strategies for mycosis fungoides.
KW - B-cells
KW - Cutaneous t-cell lymphoma
KW - Mycosis fungoides
KW - Tumour microenvironment
U2 - 10.2340/00015555-3775
DO - 10.2340/00015555-3775
M3 - Journal article
C2 - 33686443
AN - SCOPUS:85102905080
VL - 101
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 3
M1 - adv00413
ER -
ID: 259560926