Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins
Research output: Contribution to journal › Journal article › Research › peer-review
Bacterial toxins including staphylococcal enterotoxins (SEs) have been implicated in the pathogenesis of cutaneous T-cell lymphomas (CTCLs). Here, we investigate SE-mediated interactions between nonmalignant T cells and malignant T-cell lines established from skin and blood of CTCL patients. The malignant CTCL cells express MHC class II molecules that are high-affinity receptors for SE. Although treatment with SE has no direct effect on the growth of the malignant CTCL cells, the SE-treated CTCL cells induce vigorous proliferation of the SE-responsive nonmalignant T cells. In turn, the nonmalignant T cells enhance proliferation of the malignant cells in an SE- and MHC class II-dependent manner. Furthermore, SE and, in addition, alloantigen presentation by malignant CTCL cells to irradiated nonmalignant CD4(+) T-cell lines also enhance proliferation of the malignant cells. The growth-promoting effect depends on direct cell-cell contact and soluble factors such as interleukin-2. In conclusion, we demonstrate that SE triggers a bidirectional cross talk between nonmalignant T cells and malignant CTCL cells that promotes growth of the malignant cells. This represents a novel mechanism by which infections with SE-producing bacteria may contribute to pathogenesis of CTCL.
Original language | English |
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Journal | Blood |
Volume | 109 |
Issue number | 8 |
Pages (from-to) | 3325-32 |
Number of pages | 7 |
ISSN | 0006-4971 |
DOIs | |
Publication status | Published - 2007 |
Bibliographical note
Keywords: Antigen Presentation; CD4-Positive T-Lymphocytes; Cell Communication; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Enterotoxins; Gram-Positive Bacterial Infections; Histocompatibility Antigens Class II; Humans; Interleukin-2; Lymphoma, T-Cell, Cutaneous
ID: 8544145