mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection. / Ivanova, Ellie N.; Shwetar, Jasmine; Devlin, Joseph C.; Buus, Terkild B.; Gray-Gaillard, Sophie; Koide, Akiko; Cornelius, Amber; Samanovic, Marie I.; Herrera, Alberto; Mimitou, Eleni P.; Zhang, Chenzhen; Karmacharya, Trishala; Desvignes, Ludovic; Ødum, Niels; Smibert, Peter; Ulrich, Robert J.; Mulligan, Mark J.; Koide, Shohei; Ruggles, Kelly V.; Herati, Ramin S.; Koralov, Sergei B.

In: iScience, Vol. 26, No. 12, 108572, 2023, p. 1-19.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ivanova, EN, Shwetar, J, Devlin, JC, Buus, TB, Gray-Gaillard, S, Koide, A, Cornelius, A, Samanovic, MI, Herrera, A, Mimitou, EP, Zhang, C, Karmacharya, T, Desvignes, L, Ødum, N, Smibert, P, Ulrich, RJ, Mulligan, MJ, Koide, S, Ruggles, KV, Herati, RS & Koralov, SB 2023, 'mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection', iScience, vol. 26, no. 12, 108572, pp. 1-19. https://doi.org/10.1016/j.isci.2023.108572

APA

Ivanova, E. N., Shwetar, J., Devlin, J. C., Buus, T. B., Gray-Gaillard, S., Koide, A., Cornelius, A., Samanovic, M. I., Herrera, A., Mimitou, E. P., Zhang, C., Karmacharya, T., Desvignes, L., Ødum, N., Smibert, P., Ulrich, R. J., Mulligan, M. J., Koide, S., Ruggles, K. V., ... Koralov, S. B. (2023). mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection. iScience, 26(12), 1-19. [108572]. https://doi.org/10.1016/j.isci.2023.108572

Vancouver

Ivanova EN, Shwetar J, Devlin JC, Buus TB, Gray-Gaillard S, Koide A et al. mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection. iScience. 2023;26(12):1-19. 108572. https://doi.org/10.1016/j.isci.2023.108572

Author

Ivanova, Ellie N. ; Shwetar, Jasmine ; Devlin, Joseph C. ; Buus, Terkild B. ; Gray-Gaillard, Sophie ; Koide, Akiko ; Cornelius, Amber ; Samanovic, Marie I. ; Herrera, Alberto ; Mimitou, Eleni P. ; Zhang, Chenzhen ; Karmacharya, Trishala ; Desvignes, Ludovic ; Ødum, Niels ; Smibert, Peter ; Ulrich, Robert J. ; Mulligan, Mark J. ; Koide, Shohei ; Ruggles, Kelly V. ; Herati, Ramin S. ; Koralov, Sergei B. / mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection. In: iScience. 2023 ; Vol. 26, No. 12. pp. 1-19.

Bibtex

@article{2b56e48f2dca4a34bbd8a32c38a5422c,
title = "mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection",
abstract = "SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We profiled immune responses via transcriptional analysis and lymphocyte repertoire reconstruction. COVID-19 patients displayed an enhanced interferon signature and cytotoxic gene upregulation, absent in vaccine recipients. B and T cell repertoire analysis revealed clonal expansion among effector cells in COVID-19 patients and memory cells in vaccine recipients. Furthermore, while clonal αβ T cell responses were observed in both COVID-19 patients and vaccine recipients, expansion of clonal γδ T cells was found only in infected individuals. Our dataset enables side-by-side comparison of immune responses to infection versus vaccination, including clonal B and T cell responses. Our comparative analysis shows that vaccination induces a robust, durable clonal B and T cell responses, without the severe inflammation associated with infection.",
keywords = "Immune response, Immunology, Transcriptomics",
author = "Ivanova, {Ellie N.} and Jasmine Shwetar and Devlin, {Joseph C.} and Buus, {Terkild B.} and Sophie Gray-Gaillard and Akiko Koide and Amber Cornelius and Samanovic, {Marie I.} and Alberto Herrera and Mimitou, {Eleni P.} and Chenzhen Zhang and Trishala Karmacharya and Ludovic Desvignes and Niels {\O}dum and Peter Smibert and Ulrich, {Robert J.} and Mulligan, {Mark J.} and Shohei Koide and Ruggles, {Kelly V.} and Herati, {Ramin S.} and Koralov, {Sergei B.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.isci.2023.108572",
language = "English",
volume = "26",
pages = "1--19",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

AU - Ivanova, Ellie N.

AU - Shwetar, Jasmine

AU - Devlin, Joseph C.

AU - Buus, Terkild B.

AU - Gray-Gaillard, Sophie

AU - Koide, Akiko

AU - Cornelius, Amber

AU - Samanovic, Marie I.

AU - Herrera, Alberto

AU - Mimitou, Eleni P.

AU - Zhang, Chenzhen

AU - Karmacharya, Trishala

AU - Desvignes, Ludovic

AU - Ødum, Niels

AU - Smibert, Peter

AU - Ulrich, Robert J.

AU - Mulligan, Mark J.

AU - Koide, Shohei

AU - Ruggles, Kelly V.

AU - Herati, Ramin S.

AU - Koralov, Sergei B.

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We profiled immune responses via transcriptional analysis and lymphocyte repertoire reconstruction. COVID-19 patients displayed an enhanced interferon signature and cytotoxic gene upregulation, absent in vaccine recipients. B and T cell repertoire analysis revealed clonal expansion among effector cells in COVID-19 patients and memory cells in vaccine recipients. Furthermore, while clonal αβ T cell responses were observed in both COVID-19 patients and vaccine recipients, expansion of clonal γδ T cells was found only in infected individuals. Our dataset enables side-by-side comparison of immune responses to infection versus vaccination, including clonal B and T cell responses. Our comparative analysis shows that vaccination induces a robust, durable clonal B and T cell responses, without the severe inflammation associated with infection.

AB - SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We profiled immune responses via transcriptional analysis and lymphocyte repertoire reconstruction. COVID-19 patients displayed an enhanced interferon signature and cytotoxic gene upregulation, absent in vaccine recipients. B and T cell repertoire analysis revealed clonal expansion among effector cells in COVID-19 patients and memory cells in vaccine recipients. Furthermore, while clonal αβ T cell responses were observed in both COVID-19 patients and vaccine recipients, expansion of clonal γδ T cells was found only in infected individuals. Our dataset enables side-by-side comparison of immune responses to infection versus vaccination, including clonal B and T cell responses. Our comparative analysis shows that vaccination induces a robust, durable clonal B and T cell responses, without the severe inflammation associated with infection.

KW - Immune response

KW - Immunology

KW - Transcriptomics

U2 - 10.1016/j.isci.2023.108572

DO - 10.1016/j.isci.2023.108572

M3 - Journal article

C2 - 38213787

AN - SCOPUS:85179086246

VL - 26

SP - 1

EP - 19

JO - iScience

JF - iScience

SN - 2589-0042

IS - 12

M1 - 108572

ER -

ID: 377822551