Clinical and histological characteristics of mycosis fungoides and sézary syndrome: A retrospective, single-centre study of 43 patients from eastern Denmark
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- Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark
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Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathologicadata for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients’ mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01)All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8–) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort.
Original language | English |
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Journal | Acta Dermato-Venereologica |
Volume | 99 |
Issue number | 13 |
Pages (from-to) | 1231-1236 |
Number of pages | 6 |
ISSN | 0001-5555 |
DOIs | |
Publication status | Published - 2019 |
- Cutaneous T-cell lymphoma, Mycosis fungoides, Non-Hodgkin lymphoma, Sézary syndrome
Research areas
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