Clinical and histological characteristics of mycosis fungoides and sézary syndrome: A retrospective, single-centre study of 43 patients from eastern Denmark
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Clinical and histological characteristics of mycosis fungoides and sézary syndrome : A retrospective, single-centre study of 43 patients from eastern Denmark. / Nielsen, Pia Rude; Eriksen, Jens Ole; Wehkamp, Ulrike; Lindahl, Lise Maria; Gniadecki, Robert; Fogh, Hanne; Fabricius, Susanne; Bzorek, Michael; Ødum, Niels; Gjerdrum, Lise Mette Rahbek.
In: Acta Dermato-Venereologica, Vol. 99, No. 13, 2019, p. 1231-1236.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical and histological characteristics of mycosis fungoides and sézary syndrome
T2 - A retrospective, single-centre study of 43 patients from eastern Denmark
AU - Nielsen, Pia Rude
AU - Eriksen, Jens Ole
AU - Wehkamp, Ulrike
AU - Lindahl, Lise Maria
AU - Gniadecki, Robert
AU - Fogh, Hanne
AU - Fabricius, Susanne
AU - Bzorek, Michael
AU - Ødum, Niels
AU - Gjerdrum, Lise Mette Rahbek
PY - 2019
Y1 - 2019
N2 - Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathologicadata for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients’ mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01)All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8–) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort.
AB - Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathologicadata for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnosis the patients’ mean age was 64.3 years and 74.5% had early-stage (≤IIA) disease. The mean time from onset of skin disease to diagnosis was 4.4 years. Surprisingly, 43% progressed to a higher disease stage, and risk of disease progression was higher for stage IB than IA (p = 0.01)All cases displayed some degree of epidermotropism and the infiltrates consisted of pleomorphic lymphocytes with a T-helper (CD4+/CD8–) phenotype. This study describes, for the first time, all aspects of clinical and histopathological findings in patients with mycosis fungoides and Sézary syndrome in a well-characterized Danish cohort.
KW - Cutaneous T-cell lymphoma
KW - Mycosis fungoides
KW - Non-Hodgkin lymphoma
KW - Sézary syndrome
U2 - 10.2340/00015555-3351
DO - 10.2340/00015555-3351
M3 - Journal article
C2 - 31620804
AN - SCOPUS:85076585796
VL - 99
SP - 1231
EP - 1236
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 13
ER -
ID: 237100557