Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line. / Wegener, A M; Holm, B; Geisler, C; Rubin, B.

In: Scandinavian Journal of Immunology, Vol. 31, No. 5, 1990, p. 645-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wegener, AM, Holm, B, Geisler, C & Rubin, B 1990, 'Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line', Scandinavian Journal of Immunology, vol. 31, no. 5, pp. 645-56.

APA

Wegener, A. M., Holm, B., Geisler, C., & Rubin, B. (1990). Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line. Scandinavian Journal of Immunology, 31(5), 645-56.

Vancouver

Wegener AM, Holm B, Geisler C, Rubin B. Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line. Scandinavian Journal of Immunology. 1990;31(5):645-56.

Author

Wegener, A M ; Holm, B ; Geisler, C ; Rubin, B. / Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line. In: Scandinavian Journal of Immunology. 1990 ; Vol. 31, No. 5. pp. 645-56.

Bibtex

@article{7ca8bb50b0a811ddb538000ea68e967b,
title = "Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line",
abstract = "An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was poly-, oligo-, or monoclonal. The results indicate that the T lymphoma has no chromosome abnormalities, contains no tumour-inducing virus, can induce clone-specific immunity, and is oligoclonal with respect to TcR V alpha and V beta expression. The nature of the transformation event and clinical application of vaccination against T lymphomas is discussed. In addition, the expressed TcR V alpha and V beta repertoire of Con A T blasts was apparently not affected by the Igh-l or the MHC haplotype, as investigated in Igh-l and MHC congeneic C57Bl mice.",
author = "Wegener, {A M} and B Holm and C Geisler and B Rubin",
note = "Keywords: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Blotting, Northern; Blotting, Southern; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA Probes; DNA, Neoplasm; Epitopes; Immunoglobulin Variable Region; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Phenotype; RNA, Neoplasm; Receptors, Antigen, T-Cell; T-Lymphocytes",
year = "1990",
language = "English",
volume = "31",
pages = "645--56",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line

AU - Wegener, A M

AU - Holm, B

AU - Geisler, C

AU - Rubin, B

N1 - Keywords: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Blotting, Northern; Blotting, Southern; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA Probes; DNA, Neoplasm; Epitopes; Immunoglobulin Variable Region; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Phenotype; RNA, Neoplasm; Receptors, Antigen, T-Cell; T-Lymphocytes

PY - 1990

Y1 - 1990

N2 - An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was poly-, oligo-, or monoclonal. The results indicate that the T lymphoma has no chromosome abnormalities, contains no tumour-inducing virus, can induce clone-specific immunity, and is oligoclonal with respect to TcR V alpha and V beta expression. The nature of the transformation event and clinical application of vaccination against T lymphomas is discussed. In addition, the expressed TcR V alpha and V beta repertoire of Con A T blasts was apparently not affected by the Igh-l or the MHC haplotype, as investigated in Igh-l and MHC congeneic C57Bl mice.

AB - An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was poly-, oligo-, or monoclonal. The results indicate that the T lymphoma has no chromosome abnormalities, contains no tumour-inducing virus, can induce clone-specific immunity, and is oligoclonal with respect to TcR V alpha and V beta expression. The nature of the transformation event and clinical application of vaccination against T lymphomas is discussed. In addition, the expressed TcR V alpha and V beta repertoire of Con A T blasts was apparently not affected by the Igh-l or the MHC haplotype, as investigated in Igh-l and MHC congeneic C57Bl mice.

M3 - Journal article

C2 - 1693230

VL - 31

SP - 645

EP - 656

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 5

ER -

ID: 8546363