Bioinformatics
The immunological bioinformatics group develops and applies bioinformatics tools to extract knowledge from high-dimensional immunological data. We focus on single-cell and spatial transcriptomics, and apply integrative analyses to uncover dysregulated cellular interactions and tissue architectures in health and disease
The immune system is made up of diverse cell populations that constantly communicate to maintain health and respond to disease. Understanding this complex cellular ecosystem requires detailed insight into how individual cells behave, interact, and organize in tissues. As new technologies have emerged to measure the transcriptome, proteome, and spatial context of single cells, we now have unprecedented opportunities to decode the immune system in action.
Our research focuses on developing and applying computational methods to extract meaningful biological insight from high-dimensional immunological data. We work extensively with single-cell and spatial transcriptomics, as well as single-cell proteomics, to map immune cell states and interactions in both healthy and diseased tissues.
By integrating data across modalities and scales, we aim to uncover how immune responses are orchestrated at the cellular level and how these processes are altered in disease. Our long-term goal is to translate these insights into better understanding, diagnosis, and treatment of immune-mediated diseases.
Novo Nordisk Foundation Challenge Grant (2023 - 2028): "Center for Intestinal Immune Regulation (CIIR)” (co-PI)
Key collaborators:
- William Agace - University of Copenhagen (PI)
- Flemming Bengtsen - Hvidovre Hospital
- Kathy McCoy - University of Calgary
Greater Copenhagen Health Science Partners (2024 - 2027): "Clinical Academic Group in Clinical Bioinformatics” (PI)
Key Collaborator:
- Frederik Otzen Bagger - Copenhagen University Hospital
Novo Nordisk Foundation (2024 - 2026): "VAXXAIR: Vaccine pandemic preparedness through Airway immunology characterization” (co-PI)
Key collaborators:
- Jens Ulrik Stæhr Jensen - Herlev-Gentofte Hospital (PI)
- Hanne Vibeke Hansen Marquart - Copenhagen University Hospital
- Zitta Barella Harboe - Herlev-Gentofte Hospital
- Pradeesh Sivapalan - Herlev-Gentofte Hospital
- Ryan S. Thwaites - Imperial College London
- Henrik Nyhus Kløverpris - University of Copenhagen
Staff list
| Name | Title | Phone | |
|---|---|---|---|
| Aimilia Schina | External Postdoc | ||
| Andrea Michaela Sonnenholzner | PhD Fellow | ||
| Camilla Koldbæk Lemvigh | Postdoc | +4535332743 | |
| Giorgia Moranzoni | Postdoc | +4535325331 | |
| Lars Rønn Olsen | Professor | +4535334860 | |
| Søren Helweg Dam | Postdoc | +4535327016 | |
| Søren Richelsen Sandgaard | PhD Fellow | +4535321749 |