Therapeutic potential of adipose derived stromal cells for major skin inflammatory diseases
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Therapeutic potential of adipose derived stromal cells for major skin inflammatory diseases. / Galera, Marina Ramírez; Svalgaard, Jesper; Woetmann, Anders.
In: Frontiers in Medicine, Vol. 11, 1298229, 2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Therapeutic potential of adipose derived stromal cells for major skin inflammatory diseases
AU - Galera, Marina Ramírez
AU - Svalgaard, Jesper
AU - Woetmann, Anders
PY - 2024
Y1 - 2024
N2 - Inflammatory skin diseases like psoriasis and atopic dermatitis are chronic inflammatory skin conditions continuously under investigation due to increased prevalence and lack of cure. Moreover, long-term treatments available are often associated with adverse effects and drug resistance. Consequently, there is a clear unmet need for new therapeutic approaches. One promising and cutting-edge treatment option is the use of adipose-derived mesenchymal stromal cells (AD-MSCs) due to its immunomodulatory and anti-inflammatory properties. Therefore, this mini review aims to highlight why adipose-derived mesenchymal stromal cells are a potential new treatment for these diseases by summarizing the pre-clinical and clinical studies investigated up to date and addressing current limitations and unresolved clinical questions from a dermatological and immunomodulatory point of view.
AB - Inflammatory skin diseases like psoriasis and atopic dermatitis are chronic inflammatory skin conditions continuously under investigation due to increased prevalence and lack of cure. Moreover, long-term treatments available are often associated with adverse effects and drug resistance. Consequently, there is a clear unmet need for new therapeutic approaches. One promising and cutting-edge treatment option is the use of adipose-derived mesenchymal stromal cells (AD-MSCs) due to its immunomodulatory and anti-inflammatory properties. Therefore, this mini review aims to highlight why adipose-derived mesenchymal stromal cells are a potential new treatment for these diseases by summarizing the pre-clinical and clinical studies investigated up to date and addressing current limitations and unresolved clinical questions from a dermatological and immunomodulatory point of view.
U2 - 10.3389/fmed.2024.1298229
DO - 10.3389/fmed.2024.1298229
M3 - Review
C2 - 38463491
VL - 11
JO - Frontiers in Medicine
JF - Frontiers in Medicine
SN - 2296-858X
M1 - 1298229
ER -
ID: 385124460