Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. / Coquet, Jonathan M; Schuijs, Martijn J; Smyth, Mark J; Deswarte, Kim; Beyaert, Rudi; Braun, Harald; Boon, Louis; Karlsson Hedestam, Gunilla B; Nutt, Steven L; Hammad, Hamida; Lambrecht, Bart N.

In: Immunity, Vol. 43, No. 2, 18.08.2015, p. 318-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Coquet, JM, Schuijs, MJ, Smyth, MJ, Deswarte, K, Beyaert, R, Braun, H, Boon, L, Karlsson Hedestam, GB, Nutt, SL, Hammad, H & Lambrecht, BN 2015, 'Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites', Immunity, vol. 43, no. 2, pp. 318-30. https://doi.org/10.1016/j.immuni.2015.07.015

APA

Coquet, J. M., Schuijs, M. J., Smyth, M. J., Deswarte, K., Beyaert, R., Braun, H., Boon, L., Karlsson Hedestam, G. B., Nutt, S. L., Hammad, H., & Lambrecht, B. N. (2015). Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. Immunity, 43(2), 318-30. https://doi.org/10.1016/j.immuni.2015.07.015

Vancouver

Coquet JM, Schuijs MJ, Smyth MJ, Deswarte K, Beyaert R, Braun H et al. Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. Immunity. 2015 Aug 18;43(2):318-30. https://doi.org/10.1016/j.immuni.2015.07.015

Author

Coquet, Jonathan M ; Schuijs, Martijn J ; Smyth, Mark J ; Deswarte, Kim ; Beyaert, Rudi ; Braun, Harald ; Boon, Louis ; Karlsson Hedestam, Gunilla B ; Nutt, Steven L ; Hammad, Hamida ; Lambrecht, Bart N. / Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. In: Immunity. 2015 ; Vol. 43, No. 2. pp. 318-30.

Bibtex

@article{6d142c1a16fa4732a91fe276eaf21f06,
title = "Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites",
abstract = "Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.",
keywords = "Animals, Antigens, Dermatophagoides/immunology, Arthropod Proteins/immunology, Asthma/immunology, CD4-Positive T-Lymphocytes/immunology, Cells, Cultured, Cysteine Endopeptidases/immunology, Eosinophilia/immunology, Eosinophils/drug effects, Immunity, Cellular, Interleukins/administration & dosage, Lung/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Pyroglyphidae/immunology, Receptors, Antigen, T-Cell/genetics, Receptors, CXCR5/metabolism, Receptors, Interleukin-21/administration & dosage, Th2 Cells/immunology",
author = "Coquet, {Jonathan M} and Schuijs, {Martijn J} and Smyth, {Mark J} and Kim Deswarte and Rudi Beyaert and Harald Braun and Louis Boon and {Karlsson Hedestam}, {Gunilla B} and Nutt, {Steven L} and Hamida Hammad and Lambrecht, {Bart N}",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = aug,
day = "18",
doi = "10.1016/j.immuni.2015.07.015",
language = "English",
volume = "43",
pages = "318--30",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites

AU - Coquet, Jonathan M

AU - Schuijs, Martijn J

AU - Smyth, Mark J

AU - Deswarte, Kim

AU - Beyaert, Rudi

AU - Braun, Harald

AU - Boon, Louis

AU - Karlsson Hedestam, Gunilla B

AU - Nutt, Steven L

AU - Hammad, Hamida

AU - Lambrecht, Bart N

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/8/18

Y1 - 2015/8/18

N2 - Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.

AB - Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.

KW - Animals

KW - Antigens, Dermatophagoides/immunology

KW - Arthropod Proteins/immunology

KW - Asthma/immunology

KW - CD4-Positive T-Lymphocytes/immunology

KW - Cells, Cultured

KW - Cysteine Endopeptidases/immunology

KW - Eosinophilia/immunology

KW - Eosinophils/drug effects

KW - Immunity, Cellular

KW - Interleukins/administration & dosage

KW - Lung/immunology

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Pyroglyphidae/immunology

KW - Receptors, Antigen, T-Cell/genetics

KW - Receptors, CXCR5/metabolism

KW - Receptors, Interleukin-21/administration & dosage

KW - Th2 Cells/immunology

U2 - 10.1016/j.immuni.2015.07.015

DO - 10.1016/j.immuni.2015.07.015

M3 - Journal article

C2 - 26287681

VL - 43

SP - 318

EP - 330

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 2

ER -

ID: 356968852