Inflammation induced PD-L1-specific T cells

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Inflammation induced PD-L1-specific T cells. / Munir, Shamaila; Lundsager, Mia Thorup; Jørgensen, Mia Aabroe; Hansen, Morten; Petersen, Trine Hilkjær; Bonefeld, Charlotte Menne; Friese, Christina; Met, Özcan; Straten, Per Thor; Andersen, Mads Hald.

In: Cell Stress & Chaperones, Vol. 3, No. 10, 2019, p. 319-327.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Munir, S, Lundsager, MT, Jørgensen, MA, Hansen, M, Petersen, TH, Bonefeld, CM, Friese, C, Met, Ö, Straten, PT & Andersen, MH 2019, 'Inflammation induced PD-L1-specific T cells', Cell Stress & Chaperones, vol. 3, no. 10, pp. 319-327. https://doi.org/10.15698/cst2019.10.201

APA

Munir, S., Lundsager, M. T., Jørgensen, M. A., Hansen, M., Petersen, T. H., Bonefeld, C. M., Friese, C., Met, Ö., Straten, P. T., & Andersen, M. H. (2019). Inflammation induced PD-L1-specific T cells. Cell Stress & Chaperones, 3(10), 319-327. https://doi.org/10.15698/cst2019.10.201

Vancouver

Munir S, Lundsager MT, Jørgensen MA, Hansen M, Petersen TH, Bonefeld CM et al. Inflammation induced PD-L1-specific T cells. Cell Stress & Chaperones. 2019;3(10):319-327. https://doi.org/10.15698/cst2019.10.201

Author

Munir, Shamaila ; Lundsager, Mia Thorup ; Jørgensen, Mia Aabroe ; Hansen, Morten ; Petersen, Trine Hilkjær ; Bonefeld, Charlotte Menne ; Friese, Christina ; Met, Özcan ; Straten, Per Thor ; Andersen, Mads Hald. / Inflammation induced PD-L1-specific T cells. In: Cell Stress & Chaperones. 2019 ; Vol. 3, No. 10. pp. 319-327.

Bibtex

@article{201ff8ac558641868303855e19dcf276,
title = "Inflammation induced PD-L1-specific T cells",
abstract = "PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.",
author = "Shamaila Munir and Lundsager, {Mia Thorup} and J{\o}rgensen, {Mia Aabroe} and Morten Hansen and Petersen, {Trine Hilkj{\ae}r} and Bonefeld, {Charlotte Menne} and Christina Friese and {\"O}zcan Met and Straten, {Per Thor} and Andersen, {Mads Hald}",
note = "Copyright: {\textcopyright} 2019 Munir et al.",
year = "2019",
doi = "10.15698/cst2019.10.201",
language = "English",
volume = "3",
pages = "319--327",
journal = "Cell Stress and Chaperones",
issn = "1355-8145",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Inflammation induced PD-L1-specific T cells

AU - Munir, Shamaila

AU - Lundsager, Mia Thorup

AU - Jørgensen, Mia Aabroe

AU - Hansen, Morten

AU - Petersen, Trine Hilkjær

AU - Bonefeld, Charlotte Menne

AU - Friese, Christina

AU - Met, Özcan

AU - Straten, Per Thor

AU - Andersen, Mads Hald

N1 - Copyright: © 2019 Munir et al.

PY - 2019

Y1 - 2019

N2 - PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.

AB - PD-L1-specific T cells are a natural part of the T-cell repertoire in humans. Hence, we have previously described spontaneous CD8+ and CD4+ T-cell reactivity against PD-L1 in the peripheral blood of patients with various cancers as well as in healthy donors. It is well described that the expression of the PD-L1 protein is introduced in cells by pro-inflammatory cytokines, e.g. IFN-γ. In the current study, we were able to directly link inflammation with PD-L1-specific T cells by showing that inflammatory mediators such as IFN-γ generate measurable numbers of PD-L1-specific T cells in human PBMCs as well as in in vivo models. These PD-L1-specific T cells can vigorously modulate the cell compartments of the local environment. PD-L1-specific T cells may be important for immune homeostasis by sustaining the ongoing inflammatory response by the suppression of regulatory cell function both directly and indirectly.

U2 - 10.15698/cst2019.10.201

DO - 10.15698/cst2019.10.201

M3 - Journal article

C2 - 31656949

VL - 3

SP - 319

EP - 327

JO - Cell Stress and Chaperones

JF - Cell Stress and Chaperones

SN - 1355-8145

IS - 10

ER -

ID: 236720240