Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation. / Zwijnenburg, Anthonie Johan; Pokharel, Jyoti; Varnaite, Renata; Zheng, Wenning; Hoffer, Elena; Shryki, Iman; Comet, Natalia Ramirez; Ehrström, Marcus; Gredmark-Russ, Sara; Eidsmo, Liv; Gerlach, Carmen.

In: Immunity, Vol. 56, No. 8, 2023, p. 1955-1974e10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zwijnenburg, AJ, Pokharel, J, Varnaite, R, Zheng, W, Hoffer, E, Shryki, I, Comet, NR, Ehrström, M, Gredmark-Russ, S, Eidsmo, L & Gerlach, C 2023, 'Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation', Immunity, vol. 56, no. 8, pp. 1955-1974e10. https://doi.org/10.1016/j.immuni.2023.06.025

APA

Zwijnenburg, A. J., Pokharel, J., Varnaite, R., Zheng, W., Hoffer, E., Shryki, I., Comet, N. R., Ehrström, M., Gredmark-Russ, S., Eidsmo, L., & Gerlach, C. (2023). Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation. Immunity, 56(8), 1955-1974e10. https://doi.org/10.1016/j.immuni.2023.06.025

Vancouver

Zwijnenburg AJ, Pokharel J, Varnaite R, Zheng W, Hoffer E, Shryki I et al. Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation. Immunity. 2023;56(8):1955-1974e10. https://doi.org/10.1016/j.immuni.2023.06.025

Author

Zwijnenburg, Anthonie Johan ; Pokharel, Jyoti ; Varnaite, Renata ; Zheng, Wenning ; Hoffer, Elena ; Shryki, Iman ; Comet, Natalia Ramirez ; Ehrström, Marcus ; Gredmark-Russ, Sara ; Eidsmo, Liv ; Gerlach, Carmen. / Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation. In: Immunity. 2023 ; Vol. 56, No. 8. pp. 1955-1974e10.

Bibtex

@article{da97183db8224c9e93ade3390c47092f,
title = "Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation",
abstract = "T cells differentiate into functionally distinct states upon antigen encounter. These states are delineated by different cell surface markers for murine and human T cells, which hamper cross-species translation of T cell properties. We aimed to identify surface markers that reflect the graded nature of CD8+ T cell differentiation and delineate functionally comparable states in mice and humans. CITEseq analyses revealed that graded expression of CX3CR1, encoding the chemokine receptor CX3CR1, correlated with the CD8+ T cell differentiation gradient. CX3CR1 expression distinguished human and murine CD8+ and CD4+ T cell states, as defined by migratory and functional properties. Graded CX3CR1 expression, refined with CD62L, accurately captured the high-dimensional T cell differentiation continuum. Furthermore, the CX3CR1 expression gradient delineated states with comparable properties in humans and mice in steady state and on longitudinally tracked virus-specific CD8+ T cells in both species. Thus, graded CX3CR1 expression provides a strategy to translate the behavior of distinct T cell differentiation states across species.",
author = "Zwijnenburg, {Anthonie Johan} and Jyoti Pokharel and Renata Varnaite and Wenning Zheng and Elena Hoffer and Iman Shryki and Comet, {Natalia Ramirez} and Marcus Ehrstr{\"o}m and Sara Gredmark-Russ and Liv Eidsmo and Carmen Gerlach",
year = "2023",
doi = "10.1016/j.immuni.2023.06.025",
language = "English",
volume = "56",
pages = "1955--1974e10",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "8",

}

RIS

TY - JOUR

T1 - Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

AU - Zwijnenburg, Anthonie Johan

AU - Pokharel, Jyoti

AU - Varnaite, Renata

AU - Zheng, Wenning

AU - Hoffer, Elena

AU - Shryki, Iman

AU - Comet, Natalia Ramirez

AU - Ehrström, Marcus

AU - Gredmark-Russ, Sara

AU - Eidsmo, Liv

AU - Gerlach, Carmen

PY - 2023

Y1 - 2023

N2 - T cells differentiate into functionally distinct states upon antigen encounter. These states are delineated by different cell surface markers for murine and human T cells, which hamper cross-species translation of T cell properties. We aimed to identify surface markers that reflect the graded nature of CD8+ T cell differentiation and delineate functionally comparable states in mice and humans. CITEseq analyses revealed that graded expression of CX3CR1, encoding the chemokine receptor CX3CR1, correlated with the CD8+ T cell differentiation gradient. CX3CR1 expression distinguished human and murine CD8+ and CD4+ T cell states, as defined by migratory and functional properties. Graded CX3CR1 expression, refined with CD62L, accurately captured the high-dimensional T cell differentiation continuum. Furthermore, the CX3CR1 expression gradient delineated states with comparable properties in humans and mice in steady state and on longitudinally tracked virus-specific CD8+ T cells in both species. Thus, graded CX3CR1 expression provides a strategy to translate the behavior of distinct T cell differentiation states across species.

AB - T cells differentiate into functionally distinct states upon antigen encounter. These states are delineated by different cell surface markers for murine and human T cells, which hamper cross-species translation of T cell properties. We aimed to identify surface markers that reflect the graded nature of CD8+ T cell differentiation and delineate functionally comparable states in mice and humans. CITEseq analyses revealed that graded expression of CX3CR1, encoding the chemokine receptor CX3CR1, correlated with the CD8+ T cell differentiation gradient. CX3CR1 expression distinguished human and murine CD8+ and CD4+ T cell states, as defined by migratory and functional properties. Graded CX3CR1 expression, refined with CD62L, accurately captured the high-dimensional T cell differentiation continuum. Furthermore, the CX3CR1 expression gradient delineated states with comparable properties in humans and mice in steady state and on longitudinally tracked virus-specific CD8+ T cells in both species. Thus, graded CX3CR1 expression provides a strategy to translate the behavior of distinct T cell differentiation states across species.

U2 - 10.1016/j.immuni.2023.06.025

DO - 10.1016/j.immuni.2023.06.025

M3 - Journal article

C2 - 37490909

VL - 56

SP - 1955-1974e10

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 8

ER -

ID: 385022512