TY - JOUR

T1 - Does aluminium in sunscreens cause dermatitis in children with aluminium contact allergy

T2 - A repeated open application test study

AU - Hoffmann, Stine S.

AU - Elberling, Jesper

AU - Thyssen, Jacob P.

AU - Hansen, Kirsten S.

AU - Johansen, Jeanne D.

N1 - Funding Information: This study was funded by a grant from Kongelig Hofbundtmager Aage Bangs Foundation and by a grant to the National Allergy Research Centre from the Danish Environmental Protection Agency under the Ministry of Environments and Food. Publisher Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

PY - 2022/1

Y1 - 2022/1

N2 - Background: Parents report that children with aluminium contact allergy and vaccination granulomas may react to aluminium-containing sunscreen following application. Objectives: To evaluate whether contact dermatitis develops following repeated application of aluminium-containing sunscreens in children with aluminium sensitization and vaccination granulomas. Methods: Sixteen children aged 2-9 years (mean age 5 years) with vaccination granulomas and a positive patch test reaction to aluminium chloride hexahydrate 2%/10% petrolatum completed a blinded repeated open application test (ROAT) with two daily applications of two sunscreens for 14 days. One cream contained aluminium and the other did not. The children served as their own controls. Results: Sixteen children completed the study. Only one child (6%) had a positive skin reaction during ROAT on day 2 to the sunscreen with aluminium. None reacted to the sunscreen without aluminium. Conclusions: Use of aluminium-containing sunscreens may on a case basis lead to allergic contact dermatitis in aluminium allergic children.

AB - Background: Parents report that children with aluminium contact allergy and vaccination granulomas may react to aluminium-containing sunscreen following application. Objectives: To evaluate whether contact dermatitis develops following repeated application of aluminium-containing sunscreens in children with aluminium sensitization and vaccination granulomas. Methods: Sixteen children aged 2-9 years (mean age 5 years) with vaccination granulomas and a positive patch test reaction to aluminium chloride hexahydrate 2%/10% petrolatum completed a blinded repeated open application test (ROAT) with two daily applications of two sunscreens for 14 days. One cream contained aluminium and the other did not. The children served as their own controls. Results: Sixteen children completed the study. Only one child (6%) had a positive skin reaction during ROAT on day 2 to the sunscreen with aluminium. None reacted to the sunscreen without aluminium. Conclusions: Use of aluminium-containing sunscreens may on a case basis lead to allergic contact dermatitis in aluminium allergic children.

KW - allergy

KW - aluminium

KW - children

KW - dermatitis

KW - granuloma

KW - patch test

KW - ROAT

KW - vaccine

U2 - 10.1111/cod.13973

DO - 10.1111/cod.13973

M3 - Journal article

C2 - 34536036

AN - SCOPUS:85115989173

VL - 86

SP - 9

EP - 14

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 1

ER -