Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma. / Blümel, Edda; Willerslev-Olsen, Andreas; Gluud, Maria; Lindahl, Lise Maria; Fredholm, Simon; Nastasi, Claudia; Krejsgaard, Thorbjørn; Surewaard, Bas G. J.; Koralov, Sergei B.; Hu, Tengpeng; Persson, Jenny L.; Bonefeld, Charlotte Menné; Geisler, Carsten; Iversen, Lars; Becker, Jürgen C.; Andersen, Mads Hald; Woetmann, Anders; Buus, Terkild Brink; Ødum, Niels.

In: OncoImmunology, Vol. 8, No. 11, e1641387, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blümel, E, Willerslev-Olsen, A, Gluud, M, Lindahl, LM, Fredholm, S, Nastasi, C, Krejsgaard, T, Surewaard, BGJ, Koralov, SB, Hu, T, Persson, JL, Bonefeld, CM, Geisler, C, Iversen, L, Becker, JC, Andersen, MH, Woetmann, A, Buus, TB & Ødum, N 2019, 'Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma', OncoImmunology, vol. 8, no. 11, e1641387. https://doi.org/10.1080/2162402X.2019.1641387

APA

Blümel, E., Willerslev-Olsen, A., Gluud, M., Lindahl, L. M., Fredholm, S., Nastasi, C., Krejsgaard, T., Surewaard, B. G. J., Koralov, S. B., Hu, T., Persson, J. L., Bonefeld, C. M., Geisler, C., Iversen, L., Becker, J. C., Andersen, M. H., Woetmann, A., Buus, T. B., & Ødum, N. (2019). Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma. OncoImmunology, 8(11), [e1641387]. https://doi.org/10.1080/2162402X.2019.1641387

Vancouver

Blümel E, Willerslev-Olsen A, Gluud M, Lindahl LM, Fredholm S, Nastasi C et al. Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma. OncoImmunology. 2019;8(11). e1641387. https://doi.org/10.1080/2162402X.2019.1641387

Author

Blümel, Edda ; Willerslev-Olsen, Andreas ; Gluud, Maria ; Lindahl, Lise Maria ; Fredholm, Simon ; Nastasi, Claudia ; Krejsgaard, Thorbjørn ; Surewaard, Bas G. J. ; Koralov, Sergei B. ; Hu, Tengpeng ; Persson, Jenny L. ; Bonefeld, Charlotte Menné ; Geisler, Carsten ; Iversen, Lars ; Becker, Jürgen C. ; Andersen, Mads Hald ; Woetmann, Anders ; Buus, Terkild Brink ; Ødum, Niels. / Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma. In: OncoImmunology. 2019 ; Vol. 8, No. 11.

Bibtex

@article{c3bf72817b274a8ba2e9550205800e80,
title = "Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma",
abstract = "Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4+ T cells from S{\'e}zary syndrome patients are considerably more resistant to alpha-toxin-induced cell death than their non-malignant counterparts. Thus, in a subset of S{\'e}zary syndrome patients the ratio between malignant and non-malignant CD4+ T cells increases significantly following exposure to alpha-toxin. Whereas toxin-induced cell death is ADAM10 dependent in healthy CD4+ T cells, resistance to alpha-toxin in malignant T cells involves both downregulation of ADAM10 as well as other resistance mechanisms. In conclusion, we provide first evidence that Staphylococcus aureus derived alpha-toxin can tilt the balance between malignant and non-malignant CD4+ T cells in CTCL patients. Consequently, alpha-toxin may promote disease progression through positive selection of malignant CD4+ T cells, identifying alpha-toxin as a putative drug target in CTCL.",
author = "Edda Bl{\"u}mel and Andreas Willerslev-Olsen and Maria Gluud and Lindahl, {Lise Maria} and Simon Fredholm and Claudia Nastasi and Thorbj{\o}rn Krejsgaard and Surewaard, {Bas G. J.} and Koralov, {Sergei B.} and Tengpeng Hu and Persson, {Jenny L.} and Bonefeld, {Charlotte Menn{\'e}} and Carsten Geisler and Lars Iversen and Becker, {J{\"u}rgen C.} and Andersen, {Mads Hald} and Anders Woetmann and Buus, {Terkild Brink} and Niels {\O}dum",
year = "2019",
doi = "10.1080/2162402X.2019.1641387",
language = "English",
volume = "8",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Taylor & Francis",
number = "11",

}

RIS

TY - JOUR

T1 - Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma

AU - Blümel, Edda

AU - Willerslev-Olsen, Andreas

AU - Gluud, Maria

AU - Lindahl, Lise Maria

AU - Fredholm, Simon

AU - Nastasi, Claudia

AU - Krejsgaard, Thorbjørn

AU - Surewaard, Bas G. J.

AU - Koralov, Sergei B.

AU - Hu, Tengpeng

AU - Persson, Jenny L.

AU - Bonefeld, Charlotte Menné

AU - Geisler, Carsten

AU - Iversen, Lars

AU - Becker, Jürgen C.

AU - Andersen, Mads Hald

AU - Woetmann, Anders

AU - Buus, Terkild Brink

AU - Ødum, Niels

PY - 2019

Y1 - 2019

N2 - Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4+ T cells from Sézary syndrome patients are considerably more resistant to alpha-toxin-induced cell death than their non-malignant counterparts. Thus, in a subset of Sézary syndrome patients the ratio between malignant and non-malignant CD4+ T cells increases significantly following exposure to alpha-toxin. Whereas toxin-induced cell death is ADAM10 dependent in healthy CD4+ T cells, resistance to alpha-toxin in malignant T cells involves both downregulation of ADAM10 as well as other resistance mechanisms. In conclusion, we provide first evidence that Staphylococcus aureus derived alpha-toxin can tilt the balance between malignant and non-malignant CD4+ T cells in CTCL patients. Consequently, alpha-toxin may promote disease progression through positive selection of malignant CD4+ T cells, identifying alpha-toxin as a putative drug target in CTCL.

AB - Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4+ T cells from Sézary syndrome patients are considerably more resistant to alpha-toxin-induced cell death than their non-malignant counterparts. Thus, in a subset of Sézary syndrome patients the ratio between malignant and non-malignant CD4+ T cells increases significantly following exposure to alpha-toxin. Whereas toxin-induced cell death is ADAM10 dependent in healthy CD4+ T cells, resistance to alpha-toxin in malignant T cells involves both downregulation of ADAM10 as well as other resistance mechanisms. In conclusion, we provide first evidence that Staphylococcus aureus derived alpha-toxin can tilt the balance between malignant and non-malignant CD4+ T cells in CTCL patients. Consequently, alpha-toxin may promote disease progression through positive selection of malignant CD4+ T cells, identifying alpha-toxin as a putative drug target in CTCL.

U2 - 10.1080/2162402X.2019.1641387

DO - 10.1080/2162402X.2019.1641387

M3 - Journal article

C2 - 31646088

VL - 8

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 11

M1 - e1641387

ER -

ID: 226263012