Type 1 immunity enables neonatal thymic ILC1 production

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Type 1 immunity enables neonatal thymic ILC1 production. / Tougaard, Peter; Pérez, Mario R.; Steels, Wolf; Huysentruyt, Jelle; Verstraeten, Bruno; Vetters, Jessica; Divert, Tatyana; Gonçalves, Amanda; Roelandt, Ria; Takahashi, Nozomi; Janssens, Sophie; Buus, Terkild B.; Taghon, Tom; Leclercq, Georges; Vandenabeele, Peter.

In: Science Advances, Vol. 10, No. 3, eadh5520, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tougaard, P, Pérez, MR, Steels, W, Huysentruyt, J, Verstraeten, B, Vetters, J, Divert, T, Gonçalves, A, Roelandt, R, Takahashi, N, Janssens, S, Buus, TB, Taghon, T, Leclercq, G & Vandenabeele, P 2024, 'Type 1 immunity enables neonatal thymic ILC1 production', Science Advances, vol. 10, no. 3, eadh5520. https://doi.org/10.1126/sciadv.adh5520

APA

Tougaard, P., Pérez, M. R., Steels, W., Huysentruyt, J., Verstraeten, B., Vetters, J., Divert, T., Gonçalves, A., Roelandt, R., Takahashi, N., Janssens, S., Buus, T. B., Taghon, T., Leclercq, G., & Vandenabeele, P. (2024). Type 1 immunity enables neonatal thymic ILC1 production. Science Advances, 10(3), [eadh5520]. https://doi.org/10.1126/sciadv.adh5520

Vancouver

Tougaard P, Pérez MR, Steels W, Huysentruyt J, Verstraeten B, Vetters J et al. Type 1 immunity enables neonatal thymic ILC1 production. Science Advances. 2024;10(3). eadh5520. https://doi.org/10.1126/sciadv.adh5520

Author

Tougaard, Peter ; Pérez, Mario R. ; Steels, Wolf ; Huysentruyt, Jelle ; Verstraeten, Bruno ; Vetters, Jessica ; Divert, Tatyana ; Gonçalves, Amanda ; Roelandt, Ria ; Takahashi, Nozomi ; Janssens, Sophie ; Buus, Terkild B. ; Taghon, Tom ; Leclercq, Georges ; Vandenabeele, Peter. / Type 1 immunity enables neonatal thymic ILC1 production. In: Science Advances. 2024 ; Vol. 10, No. 3.

Bibtex

@article{1c20727cd2994b0ea61f3f0124b23c2e,
title = "Type 1 immunity enables neonatal thymic ILC1 production",
abstract = "Acute thymic atrophy occurs following type 1 inflammatory conditions such as viral infection and sepsis, resulting in cell death and disruption of T cell development. However, the impact type 1 immunity has on thymic-resident innate lymphoid cells (ILCs) remains unclear. Single-cell RNA sequencing revealed neonatal thymic-resident type 1 ILCs (ILC1s) as a unique and immature subset compared to ILC1s in other primary lymphoid organs. Culturing murine neonatal thymic lobes with the type 1 cytokines interleukin-12 (IL-12) and IL-18 resulted in a rapid expansion and thymic egress of KLRG1+CXCR6+ cytotoxic ILC1s. Live imaging showed the subcapsular thymic localization and exit of ILC1s following IL-12 + IL-18 stimulation. Similarly, murine cytomegalovirus infection in neonates resulted in thymic atrophy and subcapsular localization of thymic-resident ILC1s. Neonatal thymic grafting revealed that type 1 inflammation enhances the homing of cytokine-producing thymus-derived ILC1s to the liver and peritoneal cavity. Together, we show that type 1 immunity promotes the expansion and peripheral homing of thymic-derived ILC1s.",
author = "Peter Tougaard and P{\'e}rez, {Mario R.} and Wolf Steels and Jelle Huysentruyt and Bruno Verstraeten and Jessica Vetters and Tatyana Divert and Amanda Gon{\c c}alves and Ria Roelandt and Nozomi Takahashi and Sophie Janssens and Buus, {Terkild B.} and Tom Taghon and Georges Leclercq and Peter Vandenabeele",
year = "2024",
doi = "10.1126/sciadv.adh5520",
language = "English",
volume = "10",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Type 1 immunity enables neonatal thymic ILC1 production

AU - Tougaard, Peter

AU - Pérez, Mario R.

AU - Steels, Wolf

AU - Huysentruyt, Jelle

AU - Verstraeten, Bruno

AU - Vetters, Jessica

AU - Divert, Tatyana

AU - Gonçalves, Amanda

AU - Roelandt, Ria

AU - Takahashi, Nozomi

AU - Janssens, Sophie

AU - Buus, Terkild B.

AU - Taghon, Tom

AU - Leclercq, Georges

AU - Vandenabeele, Peter

PY - 2024

Y1 - 2024

N2 - Acute thymic atrophy occurs following type 1 inflammatory conditions such as viral infection and sepsis, resulting in cell death and disruption of T cell development. However, the impact type 1 immunity has on thymic-resident innate lymphoid cells (ILCs) remains unclear. Single-cell RNA sequencing revealed neonatal thymic-resident type 1 ILCs (ILC1s) as a unique and immature subset compared to ILC1s in other primary lymphoid organs. Culturing murine neonatal thymic lobes with the type 1 cytokines interleukin-12 (IL-12) and IL-18 resulted in a rapid expansion and thymic egress of KLRG1+CXCR6+ cytotoxic ILC1s. Live imaging showed the subcapsular thymic localization and exit of ILC1s following IL-12 + IL-18 stimulation. Similarly, murine cytomegalovirus infection in neonates resulted in thymic atrophy and subcapsular localization of thymic-resident ILC1s. Neonatal thymic grafting revealed that type 1 inflammation enhances the homing of cytokine-producing thymus-derived ILC1s to the liver and peritoneal cavity. Together, we show that type 1 immunity promotes the expansion and peripheral homing of thymic-derived ILC1s.

AB - Acute thymic atrophy occurs following type 1 inflammatory conditions such as viral infection and sepsis, resulting in cell death and disruption of T cell development. However, the impact type 1 immunity has on thymic-resident innate lymphoid cells (ILCs) remains unclear. Single-cell RNA sequencing revealed neonatal thymic-resident type 1 ILCs (ILC1s) as a unique and immature subset compared to ILC1s in other primary lymphoid organs. Culturing murine neonatal thymic lobes with the type 1 cytokines interleukin-12 (IL-12) and IL-18 resulted in a rapid expansion and thymic egress of KLRG1+CXCR6+ cytotoxic ILC1s. Live imaging showed the subcapsular thymic localization and exit of ILC1s following IL-12 + IL-18 stimulation. Similarly, murine cytomegalovirus infection in neonates resulted in thymic atrophy and subcapsular localization of thymic-resident ILC1s. Neonatal thymic grafting revealed that type 1 inflammation enhances the homing of cytokine-producing thymus-derived ILC1s to the liver and peritoneal cavity. Together, we show that type 1 immunity promotes the expansion and peripheral homing of thymic-derived ILC1s.

U2 - 10.1126/sciadv.adh5520

DO - 10.1126/sciadv.adh5520

M3 - Journal article

C2 - 38232171

AN - SCOPUS:85182793581

VL - 10

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 3

M1 - eadh5520

ER -

ID: 380749102