Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

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Standard

Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus. / Buus, Terkild Brink; Ødum, Niels; Geisler, Carsten; Lauritsen, Jens Peter Holst.

In: Nature Communications, Vol. 8, No. 1911, 1911, 04.12.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Buus, TB, Ødum, N, Geisler, C & Lauritsen, JPH 2017, 'Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus', Nature Communications, vol. 8, no. 1911, 1911. https://doi.org/10.1038/s41467-017-01963-w

APA

Buus, T. B., Ødum, N., Geisler, C., & Lauritsen, J. P. H. (2017). Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus. Nature Communications, 8(1911), [1911]. https://doi.org/10.1038/s41467-017-01963-w

Vancouver

Buus TB, Ødum N, Geisler C, Lauritsen JPH. Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus. Nature Communications. 2017 Dec 4;8(1911). 1911. https://doi.org/10.1038/s41467-017-01963-w

Author

Buus, Terkild Brink ; Ødum, Niels ; Geisler, Carsten ; Lauritsen, Jens Peter Holst. / Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus. In: Nature Communications. 2017 ; Vol. 8, No. 1911.

Bibtex

@article{53cc2e16515047deb793adf07d018ccb,
title = "Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus",
abstract = "Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells.",
author = "Buus, {Terkild Brink} and Niels {\O}dum and Carsten Geisler and Lauritsen, {Jens Peter Holst}",
year = "2017",
month = dec,
day = "4",
doi = "10.1038/s41467-017-01963-w",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1911",

}

RIS

TY - JOUR

T1 - Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

AU - Buus, Terkild Brink

AU - Ødum, Niels

AU - Geisler, Carsten

AU - Lauritsen, Jens Peter Holst

PY - 2017/12/4

Y1 - 2017/12/4

N2 - Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells.

AB - Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells.

U2 - 10.1038/s41467-017-01963-w

DO - 10.1038/s41467-017-01963-w

M3 - Journal article

C2 - 29203769

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1911

M1 - 1911

ER -

ID: 186447603