The vitamin d receptor and T cell function

Research output: Contribution to journal › Journal article › Research › peer-review

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The vitamin d receptor and T cell function. / Kongsbak, Martin; Levring, Trine B; Geisler, Carsten; von Essen, Marina Rode.

In: Frontiers in Immunology, Vol. 4, 148, 2013, p. 148.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kongsbak, M, Levring, TB, Geisler, C & von Essen, MR 2013, 'The vitamin d receptor and T cell function', Frontiers in Immunology, vol. 4, 148, pp. 148. https://doi.org/10.3389/fimmu.2013.00148

APA

Kongsbak, M., Levring, T. B., Geisler, C., & von Essen, M. R. (2013). The vitamin d receptor and T cell function. Frontiers in Immunology, 4, 148. [148]. https://doi.org/10.3389/fimmu.2013.00148

Vancouver

Kongsbak M, Levring TB, Geisler C, von Essen MR. The vitamin d receptor and T cell function. Frontiers in Immunology. 2013;4:148. 148. https://doi.org/10.3389/fimmu.2013.00148

Author

Kongsbak, Martin ; Levring, Trine B ; Geisler, Carsten ; von Essen, Marina Rode. / The vitamin d receptor and T cell function. In: Frontiers in Immunology. 2013 ; Vol. 4. pp. 148.

Bibtex

@article{3299712ddc064e8299959e1e5728d9f6,
title = "The vitamin d receptor and T cell function",
abstract = "The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions. The impact of 1,25(OH)2D3-VDR signaling on immune function has been the focus of many recent studies as a link between 1,25(OH)2D3 and susceptibility to various infections and to development of a variety of inflammatory diseases has been suggested. It is also becoming increasingly clear that microbes slow down immune reactivity by dysregulating the VDR ultimately to increase their chance of survival. Immune modulatory therapies that enhance VDR expression and activity are therefore considered in the clinic today to a greater extent. As T cells are of great importance for both protective immunity and development of inflammatory diseases a variety of studies have been engaged investigating the impact of VDR expression in T cells and found that VDR expression and activity plays an important role in both T cell development, differentiation and effector function. In this review we will analyze current knowledge of VDR regulation and function in T cells and discuss its importance for immune activity.",
author = "Martin Kongsbak and Levring, {Trine B} and Carsten Geisler and {von Essen}, {Marina Rode}",
year = "2013",
doi = "10.3389/fimmu.2013.00148",
language = "English",
volume = "4",
pages = "148",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The vitamin d receptor and T cell function

AU - Kongsbak, Martin

AU - Levring, Trine B

AU - Geisler, Carsten

AU - von Essen, Marina Rode

PY - 2013

Y1 - 2013

N2 - The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions. The impact of 1,25(OH)2D3-VDR signaling on immune function has been the focus of many recent studies as a link between 1,25(OH)2D3 and susceptibility to various infections and to development of a variety of inflammatory diseases has been suggested. It is also becoming increasingly clear that microbes slow down immune reactivity by dysregulating the VDR ultimately to increase their chance of survival. Immune modulatory therapies that enhance VDR expression and activity are therefore considered in the clinic today to a greater extent. As T cells are of great importance for both protective immunity and development of inflammatory diseases a variety of studies have been engaged investigating the impact of VDR expression in T cells and found that VDR expression and activity plays an important role in both T cell development, differentiation and effector function. In this review we will analyze current knowledge of VDR regulation and function in T cells and discuss its importance for immune activity.

AB - The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions. The impact of 1,25(OH)2D3-VDR signaling on immune function has been the focus of many recent studies as a link between 1,25(OH)2D3 and susceptibility to various infections and to development of a variety of inflammatory diseases has been suggested. It is also becoming increasingly clear that microbes slow down immune reactivity by dysregulating the VDR ultimately to increase their chance of survival. Immune modulatory therapies that enhance VDR expression and activity are therefore considered in the clinic today to a greater extent. As T cells are of great importance for both protective immunity and development of inflammatory diseases a variety of studies have been engaged investigating the impact of VDR expression in T cells and found that VDR expression and activity plays an important role in both T cell development, differentiation and effector function. In this review we will analyze current knowledge of VDR regulation and function in T cells and discuss its importance for immune activity.

U2 - 10.3389/fimmu.2013.00148

DO - 10.3389/fimmu.2013.00148

M3 - Journal article

C2 - 23785369

VL - 4

SP - 148

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 148

ER -

ID: 46485232