The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation. / Kastrup, J; Lauritsen, Jens Peter Holst; Menné, C; Dietrich, J; Geisler, C.

In: Scandinavian Journal of Immunology, Vol. 51, No. 5, 2000, p. 491-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kastrup, J, Lauritsen, JPH, Menné, C, Dietrich, J & Geisler, C 2000, 'The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation', Scandinavian Journal of Immunology, vol. 51, no. 5, pp. 491-6.

APA

Kastrup, J., Lauritsen, J. P. H., Menné, C., Dietrich, J., & Geisler, C. (2000). The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation. Scandinavian Journal of Immunology, 51(5), 491-6.

Vancouver

Kastrup J, Lauritsen JPH, Menné C, Dietrich J, Geisler C. The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation. Scandinavian Journal of Immunology. 2000;51(5):491-6.

Author

Kastrup, J ; Lauritsen, Jens Peter Holst ; Menné, C ; Dietrich, J ; Geisler, C. / The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation. In: Scandinavian Journal of Immunology. 2000 ; Vol. 51, No. 5. pp. 491-6.

Bibtex

@article{9414bb00b0a211ddb538000ea68e967b,
title = "The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation",
abstract = "Down-regulation of the T-cell receptor (TCR) plays an important role in modulating T-cell responses, both during T-cell development and in mature T cells. At least two distinct pathways exist for TCR down-regulation: down-regulation following TCR ligation; and down-regulation following activation of protein kinase C (PKC). Ligand-induced TCR down-regulation is dependent on protein tyrosine kinase (PTK) activity and seems to be closely related to T-cell activation. In addition, previous studies have indicated that ligand-induced TCR down-regulation is dependent on the expression of CD45, a transmembrane protein tyrosine phosphatase. The role of the different domains of CD45 in TCR down-regulation was investigated in this study. We found that the phosphatase domains of CD45 are required for efficient ligand-induced TCR down-regulation. In contrast, the extracellular domain of CD45 is dispensable for ligand-mediated TCR down-regulation. Finally, PKC-mediated TCR down-regulation was found to be independent of both the extra-and intracellular domains of CD45.",
author = "J Kastrup and Lauritsen, {Jens Peter Holst} and C Menn{\'e} and J Dietrich and C Geisler",
note = "Keywords: Antigens, CD45; Binding Sites; Extracellular Space; Humans; Intracellular Fluid; Jurkat Cells; Ligands; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Receptors, Antigen, T-Cell; Tyrosine",
year = "2000",
language = "English",
volume = "51",
pages = "491--6",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - The phosphatase domains of CD45 are required for ligand induced T-cell receptor downregulation

AU - Kastrup, J

AU - Lauritsen, Jens Peter Holst

AU - Menné, C

AU - Dietrich, J

AU - Geisler, C

N1 - Keywords: Antigens, CD45; Binding Sites; Extracellular Space; Humans; Intracellular Fluid; Jurkat Cells; Ligands; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Receptors, Antigen, T-Cell; Tyrosine

PY - 2000

Y1 - 2000

N2 - Down-regulation of the T-cell receptor (TCR) plays an important role in modulating T-cell responses, both during T-cell development and in mature T cells. At least two distinct pathways exist for TCR down-regulation: down-regulation following TCR ligation; and down-regulation following activation of protein kinase C (PKC). Ligand-induced TCR down-regulation is dependent on protein tyrosine kinase (PTK) activity and seems to be closely related to T-cell activation. In addition, previous studies have indicated that ligand-induced TCR down-regulation is dependent on the expression of CD45, a transmembrane protein tyrosine phosphatase. The role of the different domains of CD45 in TCR down-regulation was investigated in this study. We found that the phosphatase domains of CD45 are required for efficient ligand-induced TCR down-regulation. In contrast, the extracellular domain of CD45 is dispensable for ligand-mediated TCR down-regulation. Finally, PKC-mediated TCR down-regulation was found to be independent of both the extra-and intracellular domains of CD45.

AB - Down-regulation of the T-cell receptor (TCR) plays an important role in modulating T-cell responses, both during T-cell development and in mature T cells. At least two distinct pathways exist for TCR down-regulation: down-regulation following TCR ligation; and down-regulation following activation of protein kinase C (PKC). Ligand-induced TCR down-regulation is dependent on protein tyrosine kinase (PTK) activity and seems to be closely related to T-cell activation. In addition, previous studies have indicated that ligand-induced TCR down-regulation is dependent on the expression of CD45, a transmembrane protein tyrosine phosphatase. The role of the different domains of CD45 in TCR down-regulation was investigated in this study. We found that the phosphatase domains of CD45 are required for efficient ligand-induced TCR down-regulation. In contrast, the extracellular domain of CD45 is dispensable for ligand-mediated TCR down-regulation. Finally, PKC-mediated TCR down-regulation was found to be independent of both the extra-and intracellular domains of CD45.

M3 - Journal article

C2 - 10792841

VL - 51

SP - 491

EP - 496

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 5

ER -

ID: 8545075