The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndrome
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The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndrome. / Rittig, Anne Hald; Lindahl, Lise Maria; Johansen, Claus; Celis, Pamela; Ødum, Niels; Iversen, Lars; Litman, Thomas.
In: Acta Dermato-Venereologica, Vol. 99, No. 12, 2019, p. 1148-1153.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndrome
AU - Rittig, Anne Hald
AU - Lindahl, Lise Maria
AU - Johansen, Claus
AU - Celis, Pamela
AU - Ødum, Niels
AU - Iversen, Lars
AU - Litman, Thomas
PY - 2019
Y1 - 2019
N2 - It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases.
AB - It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases.
KW - Cutaneous T-cell lymphoma
KW - MicroRNA
KW - Mycosis fungoides
KW - Sézary syndrome
U2 - 10.2340/00015555-3306
DO - 10.2340/00015555-3306
M3 - Journal article
C2 - 31453630
AN - SCOPUS:85074366532
VL - 99
SP - 1148
EP - 1153
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 12
ER -
ID: 230148408