The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation
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The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.
Original language | English |
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Journal | Molecular Cell |
Volume | 68 |
Issue number | 2 |
Pages (from-to) | 265-280 |
Number of pages | 16 |
ISSN | 1097-2765 |
DOIs | |
Publication status | Published - 19 Oct 2017 |
Externally published | Yes |
Bibliographical note
Copyright © 2017 Elsevier Inc. All rights reserved.
- Animals, Cell Death, Humans, Immunity, NF-kappa B/genetics, Neoplasm Proteins/immunology, Neoplasms/immunology, Polyubiquitin/genetics, Signal Transduction
Research areas
ID: 280717758