The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity. / Mraz, Veronika; Lohmann, Rebecca K.D.; Menzel, Mandy; Hawkes, Alana; Vaher, Helen; Funch, Anders B.; Jee, Mia H.; Gadsbøll, Anne Sofie Ø.; Weber, Julie F.; Yeung, Kelvin; Ødum, Niels; Woetmann, Anders; McKay, Dianne; Witherden, Deborah; Geisler, Carsten; Bonefeld, Charlotte M.

In: Contact Dermatitis, Vol. 89, No. 5, 2023, p. e63-e65.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mraz, V, Lohmann, RKD, Menzel, M, Hawkes, A, Vaher, H, Funch, AB, Jee, MH, Gadsbøll, ASØ, Weber, JF, Yeung, K, Ødum, N, Woetmann, A, McKay, D, Witherden, D, Geisler, C & Bonefeld, CM 2023, 'The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity', Contact Dermatitis, vol. 89, no. 5, pp. e63-e65. https://doi.org/10.1111/cod.14409

APA

Mraz, V., Lohmann, R. K. D., Menzel, M., Hawkes, A., Vaher, H., Funch, A. B., Jee, M. H., Gadsbøll, A. S. Ø., Weber, J. F., Yeung, K., Ødum, N., Woetmann, A., McKay, D., Witherden, D., Geisler, C., & Bonefeld, C. M. (2023). The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity. Contact Dermatitis, 89(5), e63-e65. https://doi.org/10.1111/cod.14409

Vancouver

Mraz V, Lohmann RKD, Menzel M, Hawkes A, Vaher H, Funch AB et al. The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity. Contact Dermatitis. 2023;89(5):e63-e65. https://doi.org/10.1111/cod.14409

Author

Mraz, Veronika ; Lohmann, Rebecca K.D. ; Menzel, Mandy ; Hawkes, Alana ; Vaher, Helen ; Funch, Anders B. ; Jee, Mia H. ; Gadsbøll, Anne Sofie Ø. ; Weber, Julie F. ; Yeung, Kelvin ; Ødum, Niels ; Woetmann, Anders ; McKay, Dianne ; Witherden, Deborah ; Geisler, Carsten ; Bonefeld, Charlotte M. / The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity. In: Contact Dermatitis. 2023 ; Vol. 89, No. 5. pp. e63-e65.

Bibtex

@article{7bb8ede9f6fc4a31953a12592d2bead2,
title = "The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity",
abstract = "Background: The junctional adhesion molecule-like protein (JAML) plays important roles in wound healing and activation of epidermal γδ T cells in mice. Whether JAML plays a role in contact hypersensitivity (CHS), the animal model of allergic contact dermatitis (ACD), is not known. Methods: To examine the role of JAML in CHS, we used various mouse models of CHS in JAML knockout (KO) and wild-type (WT) mice. Furthermore, the expression of the JAML ligand coxsackievirus and adenovirus receptor (CXADR) on keratinocytes was accessed in vitro and in vivo. Results: JAML KO mice had a diminished inflammatory response during both the sensitization and elicitation phase of CHS and had reduced numbers of CD8+ and CD4+ T cells in the epidermis. Furthermore, interferon γ (IFNγ), interleukin 1β (IL-1β) and CXCL10 production were significantly reduced in JAML KO mice during the elicitation phase. We found that CD8+ T cells express JAML and that JAML is essential for rapid flare-up responses to contact allergens. Finally, we show that keratinocytes up-regulate the JAML ligand CXADR following exposure to contact allergens. Conclusion: Our study is the first to show a central role of JAML in CHS and reveals a potential new target for the treatment of ACD in humans.",
keywords = "contact hypersensitivity, CXADR, epidermal-resident memory T cell, JAML",
author = "Veronika Mraz and Lohmann, {Rebecca K.D.} and Mandy Menzel and Alana Hawkes and Helen Vaher and Funch, {Anders B.} and Jee, {Mia H.} and Gadsb{\o}ll, {Anne Sofie {\O}.} and Weber, {Julie F.} and Kelvin Yeung and Niels {\O}dum and Anders Woetmann and Dianne McKay and Deborah Witherden and Carsten Geisler and Bonefeld, {Charlotte M.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.",
year = "2023",
doi = "10.1111/cod.14409",
language = "English",
volume = "89",
pages = "e63--e65",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity

AU - Mraz, Veronika

AU - Lohmann, Rebecca K.D.

AU - Menzel, Mandy

AU - Hawkes, Alana

AU - Vaher, Helen

AU - Funch, Anders B.

AU - Jee, Mia H.

AU - Gadsbøll, Anne Sofie Ø.

AU - Weber, Julie F.

AU - Yeung, Kelvin

AU - Ødum, Niels

AU - Woetmann, Anders

AU - McKay, Dianne

AU - Witherden, Deborah

AU - Geisler, Carsten

AU - Bonefeld, Charlotte M.

N1 - Publisher Copyright: © 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

PY - 2023

Y1 - 2023

N2 - Background: The junctional adhesion molecule-like protein (JAML) plays important roles in wound healing and activation of epidermal γδ T cells in mice. Whether JAML plays a role in contact hypersensitivity (CHS), the animal model of allergic contact dermatitis (ACD), is not known. Methods: To examine the role of JAML in CHS, we used various mouse models of CHS in JAML knockout (KO) and wild-type (WT) mice. Furthermore, the expression of the JAML ligand coxsackievirus and adenovirus receptor (CXADR) on keratinocytes was accessed in vitro and in vivo. Results: JAML KO mice had a diminished inflammatory response during both the sensitization and elicitation phase of CHS and had reduced numbers of CD8+ and CD4+ T cells in the epidermis. Furthermore, interferon γ (IFNγ), interleukin 1β (IL-1β) and CXCL10 production were significantly reduced in JAML KO mice during the elicitation phase. We found that CD8+ T cells express JAML and that JAML is essential for rapid flare-up responses to contact allergens. Finally, we show that keratinocytes up-regulate the JAML ligand CXADR following exposure to contact allergens. Conclusion: Our study is the first to show a central role of JAML in CHS and reveals a potential new target for the treatment of ACD in humans.

AB - Background: The junctional adhesion molecule-like protein (JAML) plays important roles in wound healing and activation of epidermal γδ T cells in mice. Whether JAML plays a role in contact hypersensitivity (CHS), the animal model of allergic contact dermatitis (ACD), is not known. Methods: To examine the role of JAML in CHS, we used various mouse models of CHS in JAML knockout (KO) and wild-type (WT) mice. Furthermore, the expression of the JAML ligand coxsackievirus and adenovirus receptor (CXADR) on keratinocytes was accessed in vitro and in vivo. Results: JAML KO mice had a diminished inflammatory response during both the sensitization and elicitation phase of CHS and had reduced numbers of CD8+ and CD4+ T cells in the epidermis. Furthermore, interferon γ (IFNγ), interleukin 1β (IL-1β) and CXCL10 production were significantly reduced in JAML KO mice during the elicitation phase. We found that CD8+ T cells express JAML and that JAML is essential for rapid flare-up responses to contact allergens. Finally, we show that keratinocytes up-regulate the JAML ligand CXADR following exposure to contact allergens. Conclusion: Our study is the first to show a central role of JAML in CHS and reveals a potential new target for the treatment of ACD in humans.

KW - contact hypersensitivity

KW - CXADR

KW - epidermal-resident memory T cell

KW - JAML

U2 - 10.1111/cod.14409

DO - 10.1111/cod.14409

M3 - Journal article

C2 - 37619972

AN - SCOPUS:85168669425

VL - 89

SP - e63-e65

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 5

ER -

ID: 368671889