The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). / Carlsen Melander, Eva Maria; Jürgensen, Henrik J; Madsen, Daniel H; Engelholm, Lars H; Behrendt, Niels.

In: International Journal of Oncology, Vol. 47, No. 4, 10.2015, p. 1177-88.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Carlsen Melander, EM, Jürgensen, HJ, Madsen, DH, Engelholm, LH & Behrendt, N 2015, 'The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)', International Journal of Oncology, vol. 47, no. 4, pp. 1177-88. https://doi.org/10.3892/ijo.2015.3120

APA

Carlsen Melander, E. M., Jürgensen, H. J., Madsen, D. H., Engelholm, L. H., & Behrendt, N. (2015). The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). International Journal of Oncology, 47(4), 1177-88. https://doi.org/10.3892/ijo.2015.3120

Vancouver

Carlsen Melander EM, Jürgensen HJ, Madsen DH, Engelholm LH, Behrendt N. The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). International Journal of Oncology. 2015 Oct;47(4):1177-88. https://doi.org/10.3892/ijo.2015.3120

Author

Carlsen Melander, Eva Maria ; Jürgensen, Henrik J ; Madsen, Daniel H ; Engelholm, Lars H ; Behrendt, Niels. / The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). In: International Journal of Oncology. 2015 ; Vol. 47, No. 4. pp. 1177-88.

Bibtex

@article{3d06d2661553472a8f1038630f806414,
title = "The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)",
abstract = "The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.",
keywords = "Animals, Collagen, Extracellular Matrix, Humans, Neoplasms, Receptors, Mitogen, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "{Carlsen Melander}, {Eva Maria} and J{\"u}rgensen, {Henrik J} and Madsen, {Daniel H} and Engelholm, {Lars H} and Niels Behrendt",
year = "2015",
month = oct,
doi = "10.3892/ijo.2015.3120",
language = "English",
volume = "47",
pages = "1177--88",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "4",

}

RIS

TY - JOUR

T1 - The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

AU - Carlsen Melander, Eva Maria

AU - Jürgensen, Henrik J

AU - Madsen, Daniel H

AU - Engelholm, Lars H

AU - Behrendt, Niels

PY - 2015/10

Y1 - 2015/10

N2 - The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.

AB - The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.

KW - Animals

KW - Collagen

KW - Extracellular Matrix

KW - Humans

KW - Neoplasms

KW - Receptors, Mitogen

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.3892/ijo.2015.3120

DO - 10.3892/ijo.2015.3120

M3 - Journal article

C2 - 26316068

VL - 47

SP - 1177

EP - 1188

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 4

ER -

ID: 169565690