Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma. / Willerslev-Olsen, Andreas; Gjerdrum, Lise Mette Rahbek; Lindahl, Lise M.; Buus, Terkild B.; Pallesen, Emil M.H.; Gluud, Maria; Bzorek, Michael; Nielsen, Boye S.; Kamstrup, Maria R.; Rittig, Anne Hald; Bonefeld, Charlotte M.; Krejsgaard, Thorbjørn; Geisler, Carsten; Koralov, Sergei B.; Litman, Thomas; Becker, Jurgen C.; Woetmann, Anders; Iversen, Lars; Odum, Niels.

In: Journal of Investigative Dermatology, Vol. 141, No. 10, 2021, p. 2449-2458.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Willerslev-Olsen, A, Gjerdrum, LMR, Lindahl, LM, Buus, TB, Pallesen, EMH, Gluud, M, Bzorek, M, Nielsen, BS, Kamstrup, MR, Rittig, AH, Bonefeld, CM, Krejsgaard, T, Geisler, C, Koralov, SB, Litman, T, Becker, JC, Woetmann, A, Iversen, L & Odum, N 2021, 'Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma', Journal of Investigative Dermatology, vol. 141, no. 10, pp. 2449-2458. https://doi.org/10.1016/j.jid.2021.01.038

APA

Willerslev-Olsen, A., Gjerdrum, L. M. R., Lindahl, L. M., Buus, T. B., Pallesen, E. M. H., Gluud, M., Bzorek, M., Nielsen, B. S., Kamstrup, M. R., Rittig, A. H., Bonefeld, C. M., Krejsgaard, T., Geisler, C., Koralov, S. B., Litman, T., Becker, J. C., Woetmann, A., Iversen, L., & Odum, N. (2021). Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology, 141(10), 2449-2458. https://doi.org/10.1016/j.jid.2021.01.038

Vancouver

Willerslev-Olsen A, Gjerdrum LMR, Lindahl LM, Buus TB, Pallesen EMH, Gluud M et al. Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology. 2021;141(10):2449-2458. https://doi.org/10.1016/j.jid.2021.01.038

Author

Willerslev-Olsen, Andreas ; Gjerdrum, Lise Mette Rahbek ; Lindahl, Lise M. ; Buus, Terkild B. ; Pallesen, Emil M.H. ; Gluud, Maria ; Bzorek, Michael ; Nielsen, Boye S. ; Kamstrup, Maria R. ; Rittig, Anne Hald ; Bonefeld, Charlotte M. ; Krejsgaard, Thorbjørn ; Geisler, Carsten ; Koralov, Sergei B. ; Litman, Thomas ; Becker, Jurgen C. ; Woetmann, Anders ; Iversen, Lars ; Odum, Niels. / Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma. In: Journal of Investigative Dermatology. 2021 ; Vol. 141, No. 10. pp. 2449-2458.

Bibtex

@article{c1db2646771948e5b48ef414ba96947a,
title = "Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma",
abstract = "Staphylococcal enterotoxins are believed to fuel disease activity in cutaneous T-cell lymphoma. Recent data support this by showing that antibiotics inhibit malignant T cells in skin lesions in mycosis fungoides and S{\'e}zary syndrome, the most common forms of cutaneous T-cell lymphoma. Yet, it remains incompletely characterized how staphylococcal enterotoxins fuel disease activity. In this study, we show that staphylococcal enterotoxins induce the expression of the oncogenic microRNA miR-155 in primary malignant T cells. Thus, staphylococcal enterotoxins and Staphyloccocus aureus isolates from lesional skin of patients induce miR-155 expression at least partly through the IL-2Rg‒Jak‒signal transducer and activator of transcription 5 pathway, and the effect is augmented by the presence of nonmalignant T cells. Importantly, mycosis fungoides lesions harbor S. aureus, express Y-phosphorylated signal transducer and activator of transcription 5, and display enhanced miR-155 expression, when compared with nonlesional and healthy skin. Preliminary data show that aggressive antibiotic therapy is associated with decreased Y-phosphorylated signal transducer and activator of transcription 5 and miR-155 expression in lesional skin in two patients with S{\'e}zary syndrome. In conclusion, we show that S. aureus and its enterotoxins induce enhanced expression of oncogenic miR-155, providing mechanistic insight into the role of S. aureus in cutaneous T-cell lymphoma. Our findings support that environmental stimuli such as bacteria can fuel disease progression in cutaneous T-cell lymphoma.",
author = "Andreas Willerslev-Olsen and Gjerdrum, {Lise Mette Rahbek} and Lindahl, {Lise M.} and Buus, {Terkild B.} and Pallesen, {Emil M.H.} and Maria Gluud and Michael Bzorek and Nielsen, {Boye S.} and Kamstrup, {Maria R.} and Rittig, {Anne Hald} and Bonefeld, {Charlotte M.} and Thorbj{\o}rn Krejsgaard and Carsten Geisler and Koralov, {Sergei B.} and Thomas Litman and Becker, {Jurgen C.} and Anders Woetmann and Lars Iversen and Niels Odum",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
doi = "10.1016/j.jid.2021.01.038",
language = "English",
volume = "141",
pages = "2449--2458",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "10",

}

RIS

TY - JOUR

T1 - Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma

AU - Willerslev-Olsen, Andreas

AU - Gjerdrum, Lise Mette Rahbek

AU - Lindahl, Lise M.

AU - Buus, Terkild B.

AU - Pallesen, Emil M.H.

AU - Gluud, Maria

AU - Bzorek, Michael

AU - Nielsen, Boye S.

AU - Kamstrup, Maria R.

AU - Rittig, Anne Hald

AU - Bonefeld, Charlotte M.

AU - Krejsgaard, Thorbjørn

AU - Geisler, Carsten

AU - Koralov, Sergei B.

AU - Litman, Thomas

AU - Becker, Jurgen C.

AU - Woetmann, Anders

AU - Iversen, Lars

AU - Odum, Niels

N1 - Publisher Copyright: © 2021 The Authors

PY - 2021

Y1 - 2021

N2 - Staphylococcal enterotoxins are believed to fuel disease activity in cutaneous T-cell lymphoma. Recent data support this by showing that antibiotics inhibit malignant T cells in skin lesions in mycosis fungoides and Sézary syndrome, the most common forms of cutaneous T-cell lymphoma. Yet, it remains incompletely characterized how staphylococcal enterotoxins fuel disease activity. In this study, we show that staphylococcal enterotoxins induce the expression of the oncogenic microRNA miR-155 in primary malignant T cells. Thus, staphylococcal enterotoxins and Staphyloccocus aureus isolates from lesional skin of patients induce miR-155 expression at least partly through the IL-2Rg‒Jak‒signal transducer and activator of transcription 5 pathway, and the effect is augmented by the presence of nonmalignant T cells. Importantly, mycosis fungoides lesions harbor S. aureus, express Y-phosphorylated signal transducer and activator of transcription 5, and display enhanced miR-155 expression, when compared with nonlesional and healthy skin. Preliminary data show that aggressive antibiotic therapy is associated with decreased Y-phosphorylated signal transducer and activator of transcription 5 and miR-155 expression in lesional skin in two patients with Sézary syndrome. In conclusion, we show that S. aureus and its enterotoxins induce enhanced expression of oncogenic miR-155, providing mechanistic insight into the role of S. aureus in cutaneous T-cell lymphoma. Our findings support that environmental stimuli such as bacteria can fuel disease progression in cutaneous T-cell lymphoma.

AB - Staphylococcal enterotoxins are believed to fuel disease activity in cutaneous T-cell lymphoma. Recent data support this by showing that antibiotics inhibit malignant T cells in skin lesions in mycosis fungoides and Sézary syndrome, the most common forms of cutaneous T-cell lymphoma. Yet, it remains incompletely characterized how staphylococcal enterotoxins fuel disease activity. In this study, we show that staphylococcal enterotoxins induce the expression of the oncogenic microRNA miR-155 in primary malignant T cells. Thus, staphylococcal enterotoxins and Staphyloccocus aureus isolates from lesional skin of patients induce miR-155 expression at least partly through the IL-2Rg‒Jak‒signal transducer and activator of transcription 5 pathway, and the effect is augmented by the presence of nonmalignant T cells. Importantly, mycosis fungoides lesions harbor S. aureus, express Y-phosphorylated signal transducer and activator of transcription 5, and display enhanced miR-155 expression, when compared with nonlesional and healthy skin. Preliminary data show that aggressive antibiotic therapy is associated with decreased Y-phosphorylated signal transducer and activator of transcription 5 and miR-155 expression in lesional skin in two patients with Sézary syndrome. In conclusion, we show that S. aureus and its enterotoxins induce enhanced expression of oncogenic miR-155, providing mechanistic insight into the role of S. aureus in cutaneous T-cell lymphoma. Our findings support that environmental stimuli such as bacteria can fuel disease progression in cutaneous T-cell lymphoma.

U2 - 10.1016/j.jid.2021.01.038

DO - 10.1016/j.jid.2021.01.038

M3 - Journal article

C2 - 33862068

AN - SCOPUS:85105252917

VL - 141

SP - 2449

EP - 2458

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 10

ER -

ID: 262796582