Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome. / Willerslev-Olsen, Andreas; Buus, Terkild B.; Nastasi, Claudia; Blümel, Edda; Gluud, Maria; Bonefeld, Charlotte M.; Geisler, Carsten; Lindahl, Lise M.; Vermeer, Maarten; Wasik, Mariusz A.; Iversen, Lars; Becker, Jürgen C.; Andersen, Mads Hald; Gjerdrum, Lise M.R.; Litvinov, Ivan V.; Litman, Thomas; Krejsgaard, Thorbjørn; Woetmann, Anders; Ødum, Niels.

In: Blood Cancer Journal, Vol. 10, No. 5, 57, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Willerslev-Olsen, A, Buus, TB, Nastasi, C, Blümel, E, Gluud, M, Bonefeld, CM, Geisler, C, Lindahl, LM, Vermeer, M, Wasik, MA, Iversen, L, Becker, JC, Andersen, MH, Gjerdrum, LMR, Litvinov, IV, Litman, T, Krejsgaard, T, Woetmann, A & Ødum, N 2020, 'Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome', Blood Cancer Journal, vol. 10, no. 5, 57. https://doi.org/10.1038/s41408-020-0324-3

APA

Willerslev-Olsen, A., Buus, T. B., Nastasi, C., Blümel, E., Gluud, M., Bonefeld, C. M., Geisler, C., Lindahl, L. M., Vermeer, M., Wasik, M. A., Iversen, L., Becker, J. C., Andersen, M. H., Gjerdrum, L. M. R., Litvinov, I. V., Litman, T., Krejsgaard, T., Woetmann, A., & Ødum, N. (2020). Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome. Blood Cancer Journal, 10(5), [57]. https://doi.org/10.1038/s41408-020-0324-3

Vancouver

Willerslev-Olsen A, Buus TB, Nastasi C, Blümel E, Gluud M, Bonefeld CM et al. Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome. Blood Cancer Journal. 2020;10(5). 57. https://doi.org/10.1038/s41408-020-0324-3

Author

Willerslev-Olsen, Andreas ; Buus, Terkild B. ; Nastasi, Claudia ; Blümel, Edda ; Gluud, Maria ; Bonefeld, Charlotte M. ; Geisler, Carsten ; Lindahl, Lise M. ; Vermeer, Maarten ; Wasik, Mariusz A. ; Iversen, Lars ; Becker, Jürgen C. ; Andersen, Mads Hald ; Gjerdrum, Lise M.R. ; Litvinov, Ivan V. ; Litman, Thomas ; Krejsgaard, Thorbjørn ; Woetmann, Anders ; Ødum, Niels. / Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome. In: Blood Cancer Journal. 2020 ; Vol. 10, No. 5.

Bibtex

@article{54b706bc65904389aeb329cba703d5c8,
title = "Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in S{\'e}zary syndrome",
abstract = "S{\'e}zary syndrome (SS) is a heterogeneous leukemic subtype of cutaneous T-cell lymphoma (CTCL) with generalized erythroderma, lymphadenopathy, and a poor prognosis. Advanced disease is invariably associated with severe immune dysregulation and the majority of patients die from infectious complications caused by microorganisms such as, Staphylococcus aureus, rather than from the lymphoma per se. Here, we examined if staphylococcal enterotoxins (SE) may shape the phenotype of malignant SS cells, including expression of the regulatory T-cell-associated marker FOXP3. Our studies with primary and cultured malignant cells show that SE induce expression of FOXP3 in malignant cells when exposed to nonmalignant cells. Mutations in the MHC class II binding domain of SE-A (SEA) largely block the effect indicating that the response relies at least in part on the MHC class II-mediated antigen presentation. Transwell experiments show that the effect is induced by soluble factors, partly blocked by anti-IL-2 antibody, and depends on STAT5 activation in malignant cells. Collectively, these findings show that SE stimulate nonmalignant cells to induce FOXP3 expression in malignant cells. Thus, differences in exposure to environmental factors, such as bacterial toxins may explain the heterogeneous FOXP3 expression in malignant cells in SS.",
author = "Andreas Willerslev-Olsen and Buus, {Terkild B.} and Claudia Nastasi and Edda Bl{\"u}mel and Maria Gluud and Bonefeld, {Charlotte M.} and Carsten Geisler and Lindahl, {Lise M.} and Maarten Vermeer and Wasik, {Mariusz A.} and Lars Iversen and Becker, {J{\"u}rgen C.} and Andersen, {Mads Hald} and Gjerdrum, {Lise M.R.} and Litvinov, {Ivan V.} and Thomas Litman and Thorbj{\o}rn Krejsgaard and Anders Woetmann and Niels {\O}dum",
year = "2020",
doi = "10.1038/s41408-020-0324-3",
language = "English",
volume = "10",
journal = "Blood Cancer Journal",
issn = "2044-5385",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome

AU - Willerslev-Olsen, Andreas

AU - Buus, Terkild B.

AU - Nastasi, Claudia

AU - Blümel, Edda

AU - Gluud, Maria

AU - Bonefeld, Charlotte M.

AU - Geisler, Carsten

AU - Lindahl, Lise M.

AU - Vermeer, Maarten

AU - Wasik, Mariusz A.

AU - Iversen, Lars

AU - Becker, Jürgen C.

AU - Andersen, Mads Hald

AU - Gjerdrum, Lise M.R.

AU - Litvinov, Ivan V.

AU - Litman, Thomas

AU - Krejsgaard, Thorbjørn

AU - Woetmann, Anders

AU - Ødum, Niels

PY - 2020

Y1 - 2020

N2 - Sézary syndrome (SS) is a heterogeneous leukemic subtype of cutaneous T-cell lymphoma (CTCL) with generalized erythroderma, lymphadenopathy, and a poor prognosis. Advanced disease is invariably associated with severe immune dysregulation and the majority of patients die from infectious complications caused by microorganisms such as, Staphylococcus aureus, rather than from the lymphoma per se. Here, we examined if staphylococcal enterotoxins (SE) may shape the phenotype of malignant SS cells, including expression of the regulatory T-cell-associated marker FOXP3. Our studies with primary and cultured malignant cells show that SE induce expression of FOXP3 in malignant cells when exposed to nonmalignant cells. Mutations in the MHC class II binding domain of SE-A (SEA) largely block the effect indicating that the response relies at least in part on the MHC class II-mediated antigen presentation. Transwell experiments show that the effect is induced by soluble factors, partly blocked by anti-IL-2 antibody, and depends on STAT5 activation in malignant cells. Collectively, these findings show that SE stimulate nonmalignant cells to induce FOXP3 expression in malignant cells. Thus, differences in exposure to environmental factors, such as bacterial toxins may explain the heterogeneous FOXP3 expression in malignant cells in SS.

AB - Sézary syndrome (SS) is a heterogeneous leukemic subtype of cutaneous T-cell lymphoma (CTCL) with generalized erythroderma, lymphadenopathy, and a poor prognosis. Advanced disease is invariably associated with severe immune dysregulation and the majority of patients die from infectious complications caused by microorganisms such as, Staphylococcus aureus, rather than from the lymphoma per se. Here, we examined if staphylococcal enterotoxins (SE) may shape the phenotype of malignant SS cells, including expression of the regulatory T-cell-associated marker FOXP3. Our studies with primary and cultured malignant cells show that SE induce expression of FOXP3 in malignant cells when exposed to nonmalignant cells. Mutations in the MHC class II binding domain of SE-A (SEA) largely block the effect indicating that the response relies at least in part on the MHC class II-mediated antigen presentation. Transwell experiments show that the effect is induced by soluble factors, partly blocked by anti-IL-2 antibody, and depends on STAT5 activation in malignant cells. Collectively, these findings show that SE stimulate nonmalignant cells to induce FOXP3 expression in malignant cells. Thus, differences in exposure to environmental factors, such as bacterial toxins may explain the heterogeneous FOXP3 expression in malignant cells in SS.

U2 - 10.1038/s41408-020-0324-3

DO - 10.1038/s41408-020-0324-3

M3 - Journal article

C2 - 32409671

AN - SCOPUS:85084699198

VL - 10

JO - Blood Cancer Journal

JF - Blood Cancer Journal

SN - 2044-5385

IS - 5

M1 - 57

ER -

ID: 243009792