Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. / Blümel, Edda; Munir Ahmad, Shamaila; Nastasi, Claudia; Willerslev-Olsen, Andreas; Gluud, Maria; Fredholm, Simon; Hu, Tengpeng; Surewaard, Bas G.J.; Lindahl, Lise M.; Fogh, Hanne; Koralov, Sergei B.; Rahbek Gjerdrum, Lise Mette; Clark, Rachael A.; Iversen, Lars; Krejsgaard, Thorbjørn; Bonefeld, Charlotte Menné; Geisler, Carsten; Becker, Jürgen C.; Woetmann, Anders; Andersen, Mads Hald; Buus, Terkild Brink; Ødum, Niels.

In: OncoImmunology, Vol. 9, No. 1, 1751561, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blümel, E, Munir Ahmad, S, Nastasi, C, Willerslev-Olsen, A, Gluud, M, Fredholm, S, Hu, T, Surewaard, BGJ, Lindahl, LM, Fogh, H, Koralov, SB, Rahbek Gjerdrum, LM, Clark, RA, Iversen, L, Krejsgaard, T, Bonefeld, CM, Geisler, C, Becker, JC, Woetmann, A, Andersen, MH, Buus, TB & Ødum, N 2020, 'Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma', OncoImmunology, vol. 9, no. 1, 1751561. https://doi.org/10.1080/2162402X.2020.1751561

APA

Blümel, E., Munir Ahmad, S., Nastasi, C., Willerslev-Olsen, A., Gluud, M., Fredholm, S., Hu, T., Surewaard, B. G. J., Lindahl, L. M., Fogh, H., Koralov, S. B., Rahbek Gjerdrum, L. M., Clark, R. A., Iversen, L., Krejsgaard, T., Bonefeld, C. M., Geisler, C., Becker, J. C., Woetmann, A., ... Ødum, N. (2020). Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. OncoImmunology, 9(1), [1751561]. https://doi.org/10.1080/2162402X.2020.1751561

Vancouver

Blümel E, Munir Ahmad S, Nastasi C, Willerslev-Olsen A, Gluud M, Fredholm S et al. Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. OncoImmunology. 2020;9(1). 1751561. https://doi.org/10.1080/2162402X.2020.1751561

Author

Blümel, Edda ; Munir Ahmad, Shamaila ; Nastasi, Claudia ; Willerslev-Olsen, Andreas ; Gluud, Maria ; Fredholm, Simon ; Hu, Tengpeng ; Surewaard, Bas G.J. ; Lindahl, Lise M. ; Fogh, Hanne ; Koralov, Sergei B. ; Rahbek Gjerdrum, Lise Mette ; Clark, Rachael A. ; Iversen, Lars ; Krejsgaard, Thorbjørn ; Bonefeld, Charlotte Menné ; Geisler, Carsten ; Becker, Jürgen C. ; Woetmann, Anders ; Andersen, Mads Hald ; Buus, Terkild Brink ; Ødum, Niels. / Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. In: OncoImmunology. 2020 ; Vol. 9, No. 1.

Bibtex

@article{408e75ab716646108449b9b609c0e538,
title = "Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma",
abstract = "Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and S{\'e}zary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.",
keywords = "Alpha-toxin, CD8 T cells, CTCL, cytotoxicity, Staphylococcus aureus",
author = "Edda Bl{\"u}mel and {Munir Ahmad}, Shamaila and Claudia Nastasi and Andreas Willerslev-Olsen and Maria Gluud and Simon Fredholm and Tengpeng Hu and Surewaard, {Bas G.J.} and Lindahl, {Lise M.} and Hanne Fogh and Koralov, {Sergei B.} and {Rahbek Gjerdrum}, {Lise Mette} and Clark, {Rachael A.} and Lars Iversen and Thorbj{\o}rn Krejsgaard and Bonefeld, {Charlotte Menn{\'e}} and Carsten Geisler and Becker, {J{\"u}rgen C.} and Anders Woetmann and Andersen, {Mads Hald} and Buus, {Terkild Brink} and Niels {\O}dum",
year = "2020",
doi = "10.1080/2162402X.2020.1751561",
language = "English",
volume = "9",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

AU - Blümel, Edda

AU - Munir Ahmad, Shamaila

AU - Nastasi, Claudia

AU - Willerslev-Olsen, Andreas

AU - Gluud, Maria

AU - Fredholm, Simon

AU - Hu, Tengpeng

AU - Surewaard, Bas G.J.

AU - Lindahl, Lise M.

AU - Fogh, Hanne

AU - Koralov, Sergei B.

AU - Rahbek Gjerdrum, Lise Mette

AU - Clark, Rachael A.

AU - Iversen, Lars

AU - Krejsgaard, Thorbjørn

AU - Bonefeld, Charlotte Menné

AU - Geisler, Carsten

AU - Becker, Jürgen C.

AU - Woetmann, Anders

AU - Andersen, Mads Hald

AU - Buus, Terkild Brink

AU - Ødum, Niels

PY - 2020

Y1 - 2020

N2 - Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and Sézary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.

AB - Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are associated with a favorable prognosis in CTCL. Here, we show that CD8+ T cells from both healthy donors and Sézary syndrome patients are highly susceptible to cell death induced by Staphylococcal alpha-toxin, whereas malignant T cells are not. Importantly, alpha-toxin almost completely blocks cytotoxic killing of CTCL tumor cells by peptide-specific CD8+ T cells, leading to their escape from induced cell death and continued proliferation. These findings suggest that alpha-toxin may favor the persistence of malignant CTCL cells in vivo by inhibiting CD8+ T cell cytotoxicity. Thus, we propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in CTCL.

KW - Alpha-toxin

KW - CD8 T cells

KW - CTCL

KW - cytotoxicity

KW - Staphylococcus aureus

U2 - 10.1080/2162402X.2020.1751561

DO - 10.1080/2162402X.2020.1751561

M3 - Journal article

C2 - 32363124

AN - SCOPUS:85083570939

VL - 9

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 1

M1 - 1751561

ER -

ID: 243011886