SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

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Standard

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. / Brender, Christine; Columbus, Ruth; Metcalf, Donald; Handman, Emanuela; Starr, Robyn; Huntington, Nick; Tarlinton, David; Ødum, Niels; Nicholson, Sandra E; Nicola, Nicos A; Hilton, Douglas J; Alexander, Warren S.

In: Molecular and Cellular Biology, Vol. 24, No. 13, 2004, p. 6094-103.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brender, C, Columbus, R, Metcalf, D, Handman, E, Starr, R, Huntington, N, Tarlinton, D, Ødum, N, Nicholson, SE, Nicola, NA, Hilton, DJ & Alexander, WS 2004, 'SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function', Molecular and Cellular Biology, vol. 24, no. 13, pp. 6094-103. https://doi.org/10.1128/MCB.24.13.6094-6103.2004

APA

Brender, C., Columbus, R., Metcalf, D., Handman, E., Starr, R., Huntington, N., Tarlinton, D., Ødum, N., Nicholson, S. E., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2004). SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Molecular and Cellular Biology, 24(13), 6094-103. https://doi.org/10.1128/MCB.24.13.6094-6103.2004

Vancouver

Brender C, Columbus R, Metcalf D, Handman E, Starr R, Huntington N et al. SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Molecular and Cellular Biology. 2004;24(13):6094-103. https://doi.org/10.1128/MCB.24.13.6094-6103.2004

Author

Brender, Christine ; Columbus, Ruth ; Metcalf, Donald ; Handman, Emanuela ; Starr, Robyn ; Huntington, Nick ; Tarlinton, David ; Ødum, Niels ; Nicholson, Sandra E ; Nicola, Nicos A ; Hilton, Douglas J ; Alexander, Warren S. / SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. In: Molecular and Cellular Biology. 2004 ; Vol. 24, No. 13. pp. 6094-103.

Bibtex

@article{5123d3c0fd0111ddb219000ea68e967b,
title = "SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function",
abstract = "Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell responses, whereas the roles of other SOCS family members in the regulation of lymphocyte function are less clear. Here, we report the generation of mice with a targeted disruption of the Socs5 gene. Socs5(-/-) mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice. We examined antigen- and cytokine-induced proliferative responses in B and T cells in the absence of SOCS5 and found no deviations from the responses seen in wild-type cells. Because SOCS5 has been implicated in Th1 differentiation, we also investigated the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function.",
author = "Christine Brender and Ruth Columbus and Donald Metcalf and Emanuela Handman and Robyn Starr and Nick Huntington and David Tarlinton and Niels {\O}dum and Nicholson, {Sandra E} and Nicola, {Nicos A} and Hilton, {Douglas J} and Alexander, {Warren S}",
note = "Keywords: Animals; B-Lymphocytes; Cell Differentiation; Female; Hematopoiesis; Leishmania major; Leishmaniasis, Cutaneous; Lymphocyte Activation; Mice; Mice, Knockout; Protein Biosynthesis; Proteins; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; T-Lymphocytes, Helper-Inducer",
year = "2004",
doi = "10.1128/MCB.24.13.6094-6103.2004",
language = "English",
volume = "24",
pages = "6094--103",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "13",

}

RIS

TY - JOUR

T1 - SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

AU - Brender, Christine

AU - Columbus, Ruth

AU - Metcalf, Donald

AU - Handman, Emanuela

AU - Starr, Robyn

AU - Huntington, Nick

AU - Tarlinton, David

AU - Ødum, Niels

AU - Nicholson, Sandra E

AU - Nicola, Nicos A

AU - Hilton, Douglas J

AU - Alexander, Warren S

N1 - Keywords: Animals; B-Lymphocytes; Cell Differentiation; Female; Hematopoiesis; Leishmania major; Leishmaniasis, Cutaneous; Lymphocyte Activation; Mice; Mice, Knockout; Protein Biosynthesis; Proteins; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; T-Lymphocytes, Helper-Inducer

PY - 2004

Y1 - 2004

N2 - Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell responses, whereas the roles of other SOCS family members in the regulation of lymphocyte function are less clear. Here, we report the generation of mice with a targeted disruption of the Socs5 gene. Socs5(-/-) mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice. We examined antigen- and cytokine-induced proliferative responses in B and T cells in the absence of SOCS5 and found no deviations from the responses seen in wild-type cells. Because SOCS5 has been implicated in Th1 differentiation, we also investigated the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function.

AB - Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell responses, whereas the roles of other SOCS family members in the regulation of lymphocyte function are less clear. Here, we report the generation of mice with a targeted disruption of the Socs5 gene. Socs5(-/-) mice were born in a normal Mendelian ratio and were healthy and fertile. We found that SOCS5 is expressed in primary B and T cells in wild-type mice. However, no abnormalities in the lymphocyte compartment were seen in SOCS5-deficient mice. We examined antigen- and cytokine-induced proliferative responses in B and T cells in the absence of SOCS5 and found no deviations from the responses seen in wild-type cells. Because SOCS5 has been implicated in Th1 differentiation, we also investigated the importance of SOCS5 in T helper cell responses. Unexpectedly, SOCS5-deficient CD4 T cells showed no abnormalities in Th1/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major. Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function.

U2 - 10.1128/MCB.24.13.6094-6103.2004

DO - 10.1128/MCB.24.13.6094-6103.2004

M3 - Journal article

C2 - 15199163

VL - 24

SP - 6094

EP - 6103

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 13

ER -

ID: 10617056