Role of IL-22 in homeostasis and diseases of the skin

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Role of IL-22 in homeostasis and diseases of the skin. / Lopez, Daniel Villalba; Kongsbak-Wismann, Martin.

In: APMIS, Vol. 130, No. 6, 2022, p. 314-322.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Lopez, DV & Kongsbak-Wismann, M 2022, 'Role of IL-22 in homeostasis and diseases of the skin', APMIS, vol. 130, no. 6, pp. 314-322. https://doi.org/10.1111/apm.13221

APA

Lopez, D. V., & Kongsbak-Wismann, M. (2022). Role of IL-22 in homeostasis and diseases of the skin. APMIS, 130(6), 314-322. https://doi.org/10.1111/apm.13221

Vancouver

Lopez DV, Kongsbak-Wismann M. Role of IL-22 in homeostasis and diseases of the skin. APMIS. 2022;130(6):314-322. https://doi.org/10.1111/apm.13221

Author

Lopez, Daniel Villalba ; Kongsbak-Wismann, Martin. / Role of IL-22 in homeostasis and diseases of the skin. In: APMIS. 2022 ; Vol. 130, No. 6. pp. 314-322.

Bibtex

@article{5011cd4642ef444dbc2e75d919d12b87,
title = "Role of IL-22 in homeostasis and diseases of the skin",
abstract = "Interleukin-22 (IL-22) is a cytokine mainly produced by T cells and innate lymphoid cells (ILC). IL-22 primarily targets non-hematopoietic cells such as epithelial cells and fibroblasts. In the skin, IL-22 promotes the proliferation of keratinocytes and dermal fibroblasts. IL-22 furthermore regulates innate immune responses as it induces the production of antimicrobial proteins and neutrophil-attracting chemokines. IL-22 plays an important role in wound healing and in the protection against skin infections. However, IL-22 can also contribute to the pathogenesis of several inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis. In this review, current information regarding the structure, function and regulation of IL-22 is discussed with a special focus on the role of IL-22 in the skin and in skin diseases.",
keywords = "Cytokine, IL-22 receptor, immunology, inflammatory skin diseases, interleukin-22, skin",
author = "Lopez, {Daniel Villalba} and Martin Kongsbak-Wismann",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Medical Microbiology and Pathology.",
year = "2022",
doi = "10.1111/apm.13221",
language = "English",
volume = "130",
pages = "314--322",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "6",

}

RIS

TY - JOUR

T1 - Role of IL-22 in homeostasis and diseases of the skin

AU - Lopez, Daniel Villalba

AU - Kongsbak-Wismann, Martin

N1 - Publisher Copyright: © 2022 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Medical Microbiology and Pathology.

PY - 2022

Y1 - 2022

N2 - Interleukin-22 (IL-22) is a cytokine mainly produced by T cells and innate lymphoid cells (ILC). IL-22 primarily targets non-hematopoietic cells such as epithelial cells and fibroblasts. In the skin, IL-22 promotes the proliferation of keratinocytes and dermal fibroblasts. IL-22 furthermore regulates innate immune responses as it induces the production of antimicrobial proteins and neutrophil-attracting chemokines. IL-22 plays an important role in wound healing and in the protection against skin infections. However, IL-22 can also contribute to the pathogenesis of several inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis. In this review, current information regarding the structure, function and regulation of IL-22 is discussed with a special focus on the role of IL-22 in the skin and in skin diseases.

AB - Interleukin-22 (IL-22) is a cytokine mainly produced by T cells and innate lymphoid cells (ILC). IL-22 primarily targets non-hematopoietic cells such as epithelial cells and fibroblasts. In the skin, IL-22 promotes the proliferation of keratinocytes and dermal fibroblasts. IL-22 furthermore regulates innate immune responses as it induces the production of antimicrobial proteins and neutrophil-attracting chemokines. IL-22 plays an important role in wound healing and in the protection against skin infections. However, IL-22 can also contribute to the pathogenesis of several inflammatory skin diseases such as psoriasis, atopic dermatitis and allergic contact dermatitis. In this review, current information regarding the structure, function and regulation of IL-22 is discussed with a special focus on the role of IL-22 in the skin and in skin diseases.

KW - Cytokine

KW - IL-22 receptor

KW - immunology

KW - inflammatory skin diseases

KW - interleukin-22

KW - skin

U2 - 10.1111/apm.13221

DO - 10.1111/apm.13221

M3 - Review

C2 - 35316548

AN - SCOPUS:85127536876

VL - 130

SP - 314

EP - 322

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 6

ER -

ID: 305715600