RIPK2 NODs to XIAP and IBD

LEO Foundation Skin Immunology Research Center

Department of Immunology and Microbiology

RIPK2 NODs to XIAP and IBD

Research output: Contribution to journal › Review › Research › peer-review

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RIPK2 NODs to XIAP and IBD. / Topal, Yusuf; Gyrd-Hansen, Mads.

In: Seminars in Cell and Developmental Biology, Vol. 109, 2021, p. 144-150.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Topal, Y & Gyrd-Hansen, M 2021, 'RIPK2 NODs to XIAP and IBD', Seminars in Cell and Developmental Biology, vol. 109, pp. 144-150. https://doi.org/10.1016/j.semcdb.2020.07.001

APA

Topal, Y., & Gyrd-Hansen, M. (2021). RIPK2 NODs to XIAP and IBD. Seminars in Cell and Developmental Biology, 109, 144-150. https://doi.org/10.1016/j.semcdb.2020.07.001

Vancouver

Topal Y, Gyrd-Hansen M. RIPK2 NODs to XIAP and IBD. Seminars in Cell and Developmental Biology. 2021;109:144-150. https://doi.org/10.1016/j.semcdb.2020.07.001

Author

Topal, Yusuf ; Gyrd-Hansen, Mads. / RIPK2 NODs to XIAP and IBD. In: Seminars in Cell and Developmental Biology. 2021 ; Vol. 109. pp. 144-150.

Bibtex

@article{215bf3b277684c6ab65ac041da1ebe0f,

title = "RIPK2 NODs to XIAP and IBD",

abstract = "The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Recent advances suggest that the interaction between RIPK2 and XIAP is a druggable protein-protein interaction to modulate NOD1/2-dependent immune responses. Here, we discuss the mechanistic function of RIPK2 in immune signalling, its clinical relevance, and the on-going efforts to target RIPK2 in inflammatory bowel disease and beyond.",

author = "Yusuf Topal and Mads Gyrd-Hansen",

year = "2021",

doi = "10.1016/j.semcdb.2020.07.001",

language = "English",

volume = "109",

pages = "144--150",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - RIPK2 NODs to XIAP and IBD

AU - Topal, Yusuf

AU - Gyrd-Hansen, Mads

PY - 2021

Y1 - 2021

N2 - The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Recent advances suggest that the interaction between RIPK2 and XIAP is a druggable protein-protein interaction to modulate NOD1/2-dependent immune responses. Here, we discuss the mechanistic function of RIPK2 in immune signalling, its clinical relevance, and the on-going efforts to target RIPK2 in inflammatory bowel disease and beyond.

AB - The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Recent advances suggest that the interaction between RIPK2 and XIAP is a druggable protein-protein interaction to modulate NOD1/2-dependent immune responses. Here, we discuss the mechanistic function of RIPK2 in immune signalling, its clinical relevance, and the on-going efforts to target RIPK2 in inflammatory bowel disease and beyond.

U2 - 10.1016/j.semcdb.2020.07.001

DO - 10.1016/j.semcdb.2020.07.001

M3 - Review

C2 - 32631784

VL - 109

SP - 144

EP - 150

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -

ID: 280715715