Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome. / Krejsgaard, Thorbjørn Frej; Ødum, Niels; Geisler, Carsten; Wasik, M.A.; Woetmann, Anders.

In: Leukemia, Vol. 26, 2012, p. 424-432.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Krejsgaard, TF, Ødum, N, Geisler, C, Wasik, MA & Woetmann, A 2012, 'Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome', Leukemia, vol. 26, pp. 424-432. https://doi.org/10.1038/leu.2011.237

APA

Krejsgaard, T. F., Ødum, N., Geisler, C., Wasik, M. A., & Woetmann, A. (2012). Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome. Leukemia, 26, 424-432. https://doi.org/10.1038/leu.2011.237

Vancouver

Krejsgaard TF, Ødum N, Geisler C, Wasik MA, Woetmann A. Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome. Leukemia. 2012;26:424-432. https://doi.org/10.1038/leu.2011.237

Author

Krejsgaard, Thorbjørn Frej ; Ødum, Niels ; Geisler, Carsten ; Wasik, M.A. ; Woetmann, Anders. / Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome. In: Leukemia. 2012 ; Vol. 26. pp. 424-432.

Bibtex

@article{3450a8885fb54143a15b1dd98f7e7d1d,
title = "Regulatory T cells and immunodeficiency in mycosis fungoides and S{\'e}zary syndrome",
abstract = "Cutaneous T-cell lymphoma (CTCL) is the term for diseases characterized by primary accumulation of malignant T cells in the skin. Patients with the two predominant clinical forms of CTCL called mycosis fungoides (MF) and S{\'e}zary syndrome (SS) characteristically develop severe immunodeficiency during disease progression and consequently patients with advanced disease frequently die of infections and not from the tumor burden. For decades, it has been suspected that the malignant T cells actively drive the evolving immunodeficiency to avoid antitumor immunity, yet, the underlying mechanisms remain unclear. The identification of a subset of highly immunosuppressive regulatory T cells (Tregs) triggered a variety of studies investigating if MF and SS are malignant proliferations of Tregs but seemingly discordant findings have been reported. Here, we review the literature to clarify the role of Tregs in MF and SS and discuss the potential mechanisms driving the immunodeficiency.Leukemia advance online publication, 9 September 2011; doi:10.1038/leu.2011.237.",
author = "Krejsgaard, {Thorbj{\o}rn Frej} and Niels {\O}dum and Carsten Geisler and M.A. Wasik and Anders Woetmann",
year = "2012",
doi = "10.1038/leu.2011.237",
language = "English",
volume = "26",
pages = "424--432",
journal = "Leukemia",
issn = "0887-6924",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Regulatory T cells and immunodeficiency in mycosis fungoides and Sézary syndrome

AU - Krejsgaard, Thorbjørn Frej

AU - Ødum, Niels

AU - Geisler, Carsten

AU - Wasik, M.A.

AU - Woetmann, Anders

PY - 2012

Y1 - 2012

N2 - Cutaneous T-cell lymphoma (CTCL) is the term for diseases characterized by primary accumulation of malignant T cells in the skin. Patients with the two predominant clinical forms of CTCL called mycosis fungoides (MF) and Sézary syndrome (SS) characteristically develop severe immunodeficiency during disease progression and consequently patients with advanced disease frequently die of infections and not from the tumor burden. For decades, it has been suspected that the malignant T cells actively drive the evolving immunodeficiency to avoid antitumor immunity, yet, the underlying mechanisms remain unclear. The identification of a subset of highly immunosuppressive regulatory T cells (Tregs) triggered a variety of studies investigating if MF and SS are malignant proliferations of Tregs but seemingly discordant findings have been reported. Here, we review the literature to clarify the role of Tregs in MF and SS and discuss the potential mechanisms driving the immunodeficiency.Leukemia advance online publication, 9 September 2011; doi:10.1038/leu.2011.237.

AB - Cutaneous T-cell lymphoma (CTCL) is the term for diseases characterized by primary accumulation of malignant T cells in the skin. Patients with the two predominant clinical forms of CTCL called mycosis fungoides (MF) and Sézary syndrome (SS) characteristically develop severe immunodeficiency during disease progression and consequently patients with advanced disease frequently die of infections and not from the tumor burden. For decades, it has been suspected that the malignant T cells actively drive the evolving immunodeficiency to avoid antitumor immunity, yet, the underlying mechanisms remain unclear. The identification of a subset of highly immunosuppressive regulatory T cells (Tregs) triggered a variety of studies investigating if MF and SS are malignant proliferations of Tregs but seemingly discordant findings have been reported. Here, we review the literature to clarify the role of Tregs in MF and SS and discuss the potential mechanisms driving the immunodeficiency.Leukemia advance online publication, 9 September 2011; doi:10.1038/leu.2011.237.

U2 - 10.1038/leu.2011.237

DO - 10.1038/leu.2011.237

M3 - Journal article

C2 - 21904385

VL - 26

SP - 424

EP - 432

JO - Leukemia

JF - Leukemia

SN - 0887-6924

ER -

ID: 35354531