Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor : A Case Report. / Kongsbak-Wismann, Martin; Al-Jaberi, Fatima A.H.; Schmidt, Jonas Damgård; Ghanizada, Mustafa; Hansen, Cecilie Bo; Lopez, Daniel Villalba; Woetmann, Anders; Ødum, Niels; Bonefeld, Charlotte Menné; Stryhn, Anette; Garred, Peter; Buus, Søren; Geisler, Carsten.

In: Frontiers in Immunology, Vol. 12, 758154, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kongsbak-Wismann, M, Al-Jaberi, FAH, Schmidt, JD, Ghanizada, M, Hansen, CB, Lopez, DV, Woetmann, A, Ødum, N, Bonefeld, CM, Stryhn, A, Garred, P, Buus, S & Geisler, C 2021, 'Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report', Frontiers in Immunology, vol. 12, 758154. https://doi.org/10.3389/fimmu.2021.758154

APA

Kongsbak-Wismann, M., Al-Jaberi, F. A. H., Schmidt, J. D., Ghanizada, M., Hansen, C. B., Lopez, D. V., Woetmann, A., Ødum, N., Bonefeld, C. M., Stryhn, A., Garred, P., Buus, S., & Geisler, C. (2021). Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report. Frontiers in Immunology, 12, [758154]. https://doi.org/10.3389/fimmu.2021.758154

Vancouver

Kongsbak-Wismann M, Al-Jaberi FAH, Schmidt JD, Ghanizada M, Hansen CB, Lopez DV et al. Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report. Frontiers in Immunology. 2021;12. 758154. https://doi.org/10.3389/fimmu.2021.758154

Author

Kongsbak-Wismann, Martin ; Al-Jaberi, Fatima A.H. ; Schmidt, Jonas Damgård ; Ghanizada, Mustafa ; Hansen, Cecilie Bo ; Lopez, Daniel Villalba ; Woetmann, Anders ; Ødum, Niels ; Bonefeld, Charlotte Menné ; Stryhn, Anette ; Garred, Peter ; Buus, Søren ; Geisler, Carsten. / Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor : A Case Report. In: Frontiers in Immunology. 2021 ; Vol. 12.

Bibtex

@article{0ee9b79d155b4aebaad736d1357426ca,
title = "Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report",
abstract = "The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.",
keywords = "adaptive immunity, COVID-19, HVDRR, SARS-CoV-2, vitamin D",
author = "Martin Kongsbak-Wismann and Al-Jaberi, {Fatima A.H.} and Schmidt, {Jonas Damg{\aa}rd} and Mustafa Ghanizada and Hansen, {Cecilie Bo} and Lopez, {Daniel Villalba} and Anders Woetmann and Niels {\O}dum and Bonefeld, {Charlotte Menn{\'e}} and Anette Stryhn and Peter Garred and S{\o}ren Buus and Carsten Geisler",
note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Kongsbak-Wismann, Al-Jaberi, Schmidt, Ghanizada, Hansen, Lopez, Woetmann, {\O}dum, Bonefeld, Stryhn, Garred, Buus and Geisler.",
year = "2021",
doi = "10.3389/fimmu.2021.758154",
language = "English",
volume = "12",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor

T2 - A Case Report

AU - Kongsbak-Wismann, Martin

AU - Al-Jaberi, Fatima A.H.

AU - Schmidt, Jonas Damgård

AU - Ghanizada, Mustafa

AU - Hansen, Cecilie Bo

AU - Lopez, Daniel Villalba

AU - Woetmann, Anders

AU - Ødum, Niels

AU - Bonefeld, Charlotte Menné

AU - Stryhn, Anette

AU - Garred, Peter

AU - Buus, Søren

AU - Geisler, Carsten

N1 - Publisher Copyright: © Copyright © 2021 Kongsbak-Wismann, Al-Jaberi, Schmidt, Ghanizada, Hansen, Lopez, Woetmann, Ødum, Bonefeld, Stryhn, Garred, Buus and Geisler.

PY - 2021

Y1 - 2021

N2 - The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.

AB - The coronavirus disease 2019 (COVID-19) pandemic has severely impacted daily life all over the world. Any measures to slow down the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to decrease disease severity are highly requested. Recent studies have reported inverse correlations between plasma levels of vitamin D and susceptibility to SARS-CoV-2 infection and COVID-19 severity. Therefore, it has been proposed to supplement the general population with vitamin D to reduce the impact of COVID-19. However, by studying the course of COVID-19 and the immune response against SARS-CoV-2 in a family with a mutated, non-functional vitamin D receptor, we here demonstrate that vitamin D signaling was dispensable for mounting an efficient adaptive immune response against SARS-CoV-2 in this family. Although these observations might not directly be transferred to the general population, they question a central role of vitamin D in the generation of adaptive immunity against SARS-CoV-2.

KW - adaptive immunity

KW - COVID-19

KW - HVDRR

KW - SARS-CoV-2

KW - vitamin D

U2 - 10.3389/fimmu.2021.758154

DO - 10.3389/fimmu.2021.758154

M3 - Journal article

C2 - 34659264

AN - SCOPUS:85117089963

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 758154

ER -

ID: 283138786