miRNA Signature in Early-stage Mycosis Fungoides
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miRNA Signature in Early-stage Mycosis Fungoides. / Sørensen, Sissel T.; Litman, Thomas; Gluud, Maria; Celis, Pamela; Torres-Rusillo, Sara; Willerslev-Olsen, Andreas; Ødum, Niels; Iversen, Lars; Lindahl, Lise M.
In: Acta Dermato-Venereologica, Vol. 102, adv00785, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - miRNA Signature in Early-stage Mycosis Fungoides
AU - Sørensen, Sissel T.
AU - Litman, Thomas
AU - Gluud, Maria
AU - Celis, Pamela
AU - Torres-Rusillo, Sara
AU - Willerslev-Olsen, Andreas
AU - Ødum, Niels
AU - Iversen, Lars
AU - Lindahl, Lise M.
N1 - Publisher Copyright: © 2022, Medical Journals/Acta D-V. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Altered miRNA expressions are assigned pathoge-nic properties in several cancers including mycosis fungoides and could play a role in the early onset of the disease. The aim of this study was to exami-ne disease-specific miRNA expression in early-stage mycosis fungoides patch and plaque lesions. A quanti-tative real-time PCR platform of 384 human miRNAs was used to study miRNA expression in 154 diagnostic mycosis fungoides biopsies. A total of 110 miRNAs were significantly differentially expressed (>2-fold, p < 0.05) between plaque lesions and healthy con-trols, and 90 miRNAs (>2-fold, p < 0.05) differed between patch lesions and healthy controls. Moreover, 13 miRNAs differed in expression between patch and plaque lesions. Early-stage mycosis fungoides exhibited miRNA featur es that overlapped with those of psoria-sis. However, 39 miRNAs, including miR-142-3p, miR-150 and miR-146b, were specific to mycosis fungoides. In conclusion, early-stage mycosis fungoides expres-ses a distinct miRNA profile, indicating that miRNAs could play a role in the early development of mycosis fungoides.
AB - Altered miRNA expressions are assigned pathoge-nic properties in several cancers including mycosis fungoides and could play a role in the early onset of the disease. The aim of this study was to exami-ne disease-specific miRNA expression in early-stage mycosis fungoides patch and plaque lesions. A quanti-tative real-time PCR platform of 384 human miRNAs was used to study miRNA expression in 154 diagnostic mycosis fungoides biopsies. A total of 110 miRNAs were significantly differentially expressed (>2-fold, p < 0.05) between plaque lesions and healthy con-trols, and 90 miRNAs (>2-fold, p < 0.05) differed between patch lesions and healthy controls. Moreover, 13 miRNAs differed in expression between patch and plaque lesions. Early-stage mycosis fungoides exhibited miRNA featur es that overlapped with those of psoria-sis. However, 39 miRNAs, including miR-142-3p, miR-150 and miR-146b, were specific to mycosis fungoides. In conclusion, early-stage mycosis fungoides expres-ses a distinct miRNA profile, indicating that miRNAs could play a role in the early development of mycosis fungoides.
KW - cancer
KW - cutaneous T-cell lymphoma
KW - microRNA
KW - mycosis fungoides
U2 - 10.2340/actadv.v102.628
DO - 10.2340/actadv.v102.628
M3 - Journal article
C2 - 35788691
AN - SCOPUS:85139396948
VL - 102
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
M1 - adv00785
ER -
ID: 323858408