Midline 1 controls polarization and migration of murine cytotoxic T cells

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Midline 1 controls polarization and migration of murine cytotoxic T cells. / Boding, Lasse; Hansen, Ann K; Nielsen, Morten M; Meroni, Germana; Braunstein, Thomas H; Woetmann, Anders; Ødum, Niels; Bonefeld, Charlotte M; Geisler, Carsten.

In: Immunity, Inflammation and Disease, Vol. 2, No. 4, 12.2014, p. 262-71.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Boding, L, Hansen, AK, Nielsen, MM, Meroni, G, Braunstein, TH, Woetmann, A, Ødum, N, Bonefeld, CM & Geisler, C 2014, 'Midline 1 controls polarization and migration of murine cytotoxic T cells', Immunity, Inflammation and Disease, vol. 2, no. 4, pp. 262-71. https://doi.org/10.1002/iid3.44

APA

Boding, L., Hansen, A. K., Nielsen, M. M., Meroni, G., Braunstein, T. H., Woetmann, A., Ødum, N., Bonefeld, C. M., & Geisler, C. (2014). Midline 1 controls polarization and migration of murine cytotoxic T cells. Immunity, Inflammation and Disease, 2(4), 262-71. https://doi.org/10.1002/iid3.44

Vancouver

Boding L, Hansen AK, Nielsen MM, Meroni G, Braunstein TH, Woetmann A et al. Midline 1 controls polarization and migration of murine cytotoxic T cells. Immunity, Inflammation and Disease. 2014 Dec;2(4):262-71. https://doi.org/10.1002/iid3.44

Author

Boding, Lasse ; Hansen, Ann K ; Nielsen, Morten M ; Meroni, Germana ; Braunstein, Thomas H ; Woetmann, Anders ; Ødum, Niels ; Bonefeld, Charlotte M ; Geisler, Carsten. / Midline 1 controls polarization and migration of murine cytotoxic T cells. In: Immunity, Inflammation and Disease. 2014 ; Vol. 2, No. 4. pp. 262-71.

Bibtex

@article{ad5f1139051d41888f4ddd59a17d535f,
title = "Midline 1 controls polarization and migration of murine cytotoxic T cells",
abstract = "Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2 A levels. Loss-of-function mutations in MID1 lead to the human X-linked Opitz G/BBB (OS) syndrome characterized by defective midline development during embryogenesis. We have recently shown that MID1 is strongly up-regulated in murine cytotoxic T lymphocytes (CTLs), and that it has a significant impact on exocytosis of lytic granules and the killing capacity of CTLs. The aims of the present study were to determine the localization of MID1 in migrating CTLs, and to investigate whether MID1 affects CTL polarization and migration. We found that MID1 mainly localizes to the uropod of migrating CTLs and that it has a substantial impact on CTL polarization and migration in vitro. Furthermore, analysis of contact hypersensitivity responses supported that MID1 controls effector functions of CTLs in hapten-challenged skin in vivo. These results provide significant new knowledge on the role of MID1 in CTL biology.",
author = "Lasse Boding and Hansen, {Ann K} and Nielsen, {Morten M} and Germana Meroni and Braunstein, {Thomas H} and Anders Woetmann and Niels {\O}dum and Bonefeld, {Charlotte M} and Carsten Geisler",
year = "2014",
month = dec,
doi = "10.1002/iid3.44",
language = "English",
volume = "2",
pages = "262--71",
journal = "Immunity, inflammation and disease",
issn = "2050-4527",
publisher = "JohnWiley & Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Midline 1 controls polarization and migration of murine cytotoxic T cells

AU - Boding, Lasse

AU - Hansen, Ann K

AU - Nielsen, Morten M

AU - Meroni, Germana

AU - Braunstein, Thomas H

AU - Woetmann, Anders

AU - Ødum, Niels

AU - Bonefeld, Charlotte M

AU - Geisler, Carsten

PY - 2014/12

Y1 - 2014/12

N2 - Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2 A levels. Loss-of-function mutations in MID1 lead to the human X-linked Opitz G/BBB (OS) syndrome characterized by defective midline development during embryogenesis. We have recently shown that MID1 is strongly up-regulated in murine cytotoxic T lymphocytes (CTLs), and that it has a significant impact on exocytosis of lytic granules and the killing capacity of CTLs. The aims of the present study were to determine the localization of MID1 in migrating CTLs, and to investigate whether MID1 affects CTL polarization and migration. We found that MID1 mainly localizes to the uropod of migrating CTLs and that it has a substantial impact on CTL polarization and migration in vitro. Furthermore, analysis of contact hypersensitivity responses supported that MID1 controls effector functions of CTLs in hapten-challenged skin in vivo. These results provide significant new knowledge on the role of MID1 in CTL biology.

AB - Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2 A levels. Loss-of-function mutations in MID1 lead to the human X-linked Opitz G/BBB (OS) syndrome characterized by defective midline development during embryogenesis. We have recently shown that MID1 is strongly up-regulated in murine cytotoxic T lymphocytes (CTLs), and that it has a significant impact on exocytosis of lytic granules and the killing capacity of CTLs. The aims of the present study were to determine the localization of MID1 in migrating CTLs, and to investigate whether MID1 affects CTL polarization and migration. We found that MID1 mainly localizes to the uropod of migrating CTLs and that it has a substantial impact on CTL polarization and migration in vitro. Furthermore, analysis of contact hypersensitivity responses supported that MID1 controls effector functions of CTLs in hapten-challenged skin in vivo. These results provide significant new knowledge on the role of MID1 in CTL biology.

U2 - 10.1002/iid3.44

DO - 10.1002/iid3.44

M3 - Journal article

C2 - 25866633

VL - 2

SP - 262

EP - 271

JO - Immunity, inflammation and disease

JF - Immunity, inflammation and disease

SN - 2050-4527

IS - 4

ER -

ID: 135490914