Mechanisms behind functional avidity maturation in T cells

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Mechanisms behind functional avidity maturation in T cells. / von Essen, Marina Rode; Kongsbak, Martin; Geisler, Carsten.

In: Clinical & Developmental Immunology, Vol. 2012, 163453, 01.2012.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

von Essen, MR, Kongsbak, M & Geisler, C 2012, 'Mechanisms behind functional avidity maturation in T cells', Clinical & Developmental Immunology, vol. 2012, 163453. https://doi.org/10.1155/2012/163453

APA

von Essen, M. R., Kongsbak, M., & Geisler, C. (2012). Mechanisms behind functional avidity maturation in T cells. Clinical & Developmental Immunology, 2012, [163453]. https://doi.org/10.1155/2012/163453

Vancouver

von Essen MR, Kongsbak M, Geisler C. Mechanisms behind functional avidity maturation in T cells. Clinical & Developmental Immunology. 2012 Jan;2012. 163453. https://doi.org/10.1155/2012/163453

Author

von Essen, Marina Rode ; Kongsbak, Martin ; Geisler, Carsten. / Mechanisms behind functional avidity maturation in T cells. In: Clinical & Developmental Immunology. 2012 ; Vol. 2012.

Bibtex

@article{18909c614081442fbb85a00cff859516,
title = "Mechanisms behind functional avidity maturation in T cells",
abstract = "During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (na{\"i}ve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.",
keywords = "Animals, Cell Differentiation, Cellular Microenvironment, Cytokines, Humans, Immunologic Memory, Lymphocyte Activation, Receptor Cross-Talk, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, T-Lymphocytes",
author = "{von Essen}, {Marina Rode} and Martin Kongsbak and Carsten Geisler",
year = "2012",
month = jan,
doi = "10.1155/2012/163453",
language = "English",
volume = "2012",
journal = "Journal of Immunology Research",
issn = "2314-8861",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Mechanisms behind functional avidity maturation in T cells

AU - von Essen, Marina Rode

AU - Kongsbak, Martin

AU - Geisler, Carsten

PY - 2012/1

Y1 - 2012/1

N2 - During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.

AB - During an immune response antigen-primed B-cells increase their antigen responsiveness by affinity maturation mediated by somatic hypermutation of the genes encoding the antigen-specific B-cell receptor (BCR) and by selection of higher-affinity B cell clones. Unlike the BCR, the T-cell receptor (TCR) cannot undergo affinity maturation. Nevertheless, antigen-primed T cells significantly increase their antigen responsiveness compared to antigen-inexperienced (naïve) T cells in a process called functional avidity maturation. This paper covers studies that describe differences in T-cell antigen responsiveness during T-cell differentiation along with examples of the mechanisms behind functional avidity maturation in T cells.

KW - Animals

KW - Cell Differentiation

KW - Cellular Microenvironment

KW - Cytokines

KW - Humans

KW - Immunologic Memory

KW - Lymphocyte Activation

KW - Receptor Cross-Talk

KW - Receptors, Antigen, T-Cell

KW - Signal Transduction

KW - T-Lymphocyte Subsets

KW - T-Lymphocytes

U2 - 10.1155/2012/163453

DO - 10.1155/2012/163453

M3 - Journal article

C2 - 22611418

VL - 2012

JO - Journal of Immunology Research

JF - Journal of Immunology Research

SN - 2314-8861

M1 - 163453

ER -

ID: 46485143