Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma. / Lauenborg, Britt; Christensen, Louise; Ralfkiaer, Ulrik; Kopp, Katharina Luise Maria; Jønson, Lars; Dabelsteen, Sally; Bonefeld, Charlotte M; Geisler, Carsten; Gjerdrum, Lise Mette R; Zhang, Qian; Wasik, Mariusz A; Ralfkiaer, Elisabeth; Ødum, Niels; Andersen, Anders Woetmann.

In: OncoTarget, Vol. 6, No. 17, 2015, p. 15235-15249.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lauenborg, B, Christensen, L, Ralfkiaer, U, Kopp, KLM, Jønson, L, Dabelsteen, S, Bonefeld, CM, Geisler, C, Gjerdrum, LMR, Zhang, Q, Wasik, MA, Ralfkiaer, E, Ødum, N & Andersen, AW 2015, 'Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma', OncoTarget, vol. 6, no. 17, pp. 15235-15249. https://doi.org/10.18632/oncotarget.3837

APA

Lauenborg, B., Christensen, L., Ralfkiaer, U., Kopp, K. L. M., Jønson, L., Dabelsteen, S., Bonefeld, C. M., Geisler, C., Gjerdrum, L. M. R., Zhang, Q., Wasik, M. A., Ralfkiaer, E., Ødum, N., & Andersen, A. W. (2015). Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma. OncoTarget, 6(17), 15235-15249. https://doi.org/10.18632/oncotarget.3837

Vancouver

Lauenborg B, Christensen L, Ralfkiaer U, Kopp KLM, Jønson L, Dabelsteen S et al. Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma. OncoTarget. 2015;6(17):15235-15249. https://doi.org/10.18632/oncotarget.3837

Author

Lauenborg, Britt ; Christensen, Louise ; Ralfkiaer, Ulrik ; Kopp, Katharina Luise Maria ; Jønson, Lars ; Dabelsteen, Sally ; Bonefeld, Charlotte M ; Geisler, Carsten ; Gjerdrum, Lise Mette R ; Zhang, Qian ; Wasik, Mariusz A ; Ralfkiaer, Elisabeth ; Ødum, Niels ; Andersen, Anders Woetmann. / Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma. In: OncoTarget. 2015 ; Vol. 6, No. 17. pp. 15235-15249.

Bibtex

@article{1b1740f744af46a4b3db884b1d66d127,
title = "Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma",
abstract = "Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.",
keywords = "CTCL, LTA, angiogenesis",
author = "Britt Lauenborg and Louise Christensen and Ulrik Ralfkiaer and Kopp, {Katharina Luise Maria} and Lars J{\o}nson and Sally Dabelsteen and Bonefeld, {Charlotte M} and Carsten Geisler and Gjerdrum, {Lise Mette R} and Qian Zhang and Wasik, {Mariusz A} and Elisabeth Ralfkiaer and Niels {\O}dum and Andersen, {Anders Woetmann}",
year = "2015",
doi = "10.18632/oncotarget.3837",
language = "English",
volume = "6",
pages = "15235--15249",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "17",

}

RIS

TY - JOUR

T1 - Malignant T cells express lymphotoxin alpha and drive endothelial activation in cutaneous T cell lymphoma

AU - Lauenborg, Britt

AU - Christensen, Louise

AU - Ralfkiaer, Ulrik

AU - Kopp, Katharina Luise Maria

AU - Jønson, Lars

AU - Dabelsteen, Sally

AU - Bonefeld, Charlotte M

AU - Geisler, Carsten

AU - Gjerdrum, Lise Mette R

AU - Zhang, Qian

AU - Wasik, Mariusz A

AU - Ralfkiaer, Elisabeth

AU - Ødum, Niels

AU - Andersen, Anders Woetmann

PY - 2015

Y1 - 2015

N2 - Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.

AB - Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.

KW - CTCL

KW - LTA

KW - angiogenesis

U2 - 10.18632/oncotarget.3837

DO - 10.18632/oncotarget.3837

M3 - Journal article

C2 - 25915535

VL - 6

SP - 15235

EP - 15249

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 17

ER -

ID: 156561324