Intestinal helminth infection transforms the CD4+ T cell composition of the skin

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Intestinal helminth infection transforms the CD4+ T cell composition of the skin. / Classon, Cajsa H.; Li, Muzhen; Clavero, Ada Lerma; Ma, Junjie; Feng, Xiaogang; Tibbitt, Christopher A.; Stark, Julian M.; Cardoso, Rebeca; Ringqvist, Emma; Boon, Louis; Villablanca, Eduardo J.; Rothfuchs, Antonio Gigliotti; Eidsmo, Liv; Coquet, Jonathan M.; Nylén, Susanne.

In: Mucosal Immunology, Vol. 15, 2022, p. 257–267.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Classon, CH, Li, M, Clavero, AL, Ma, J, Feng, X, Tibbitt, CA, Stark, JM, Cardoso, R, Ringqvist, E, Boon, L, Villablanca, EJ, Rothfuchs, AG, Eidsmo, L, Coquet, JM & Nylén, S 2022, 'Intestinal helminth infection transforms the CD4+ T cell composition of the skin', Mucosal Immunology, vol. 15, pp. 257–267. https://doi.org/10.1038/s41385-021-00473-9

APA

Classon, C. H., Li, M., Clavero, A. L., Ma, J., Feng, X., Tibbitt, C. A., Stark, J. M., Cardoso, R., Ringqvist, E., Boon, L., Villablanca, E. J., Rothfuchs, A. G., Eidsmo, L., Coquet, J. M., & Nylén, S. (2022). Intestinal helminth infection transforms the CD4+ T cell composition of the skin. Mucosal Immunology, 15, 257–267. https://doi.org/10.1038/s41385-021-00473-9

Vancouver

Classon CH, Li M, Clavero AL, Ma J, Feng X, Tibbitt CA et al. Intestinal helminth infection transforms the CD4+ T cell composition of the skin. Mucosal Immunology. 2022;15:257–267. https://doi.org/10.1038/s41385-021-00473-9

Author

Classon, Cajsa H. ; Li, Muzhen ; Clavero, Ada Lerma ; Ma, Junjie ; Feng, Xiaogang ; Tibbitt, Christopher A. ; Stark, Julian M. ; Cardoso, Rebeca ; Ringqvist, Emma ; Boon, Louis ; Villablanca, Eduardo J. ; Rothfuchs, Antonio Gigliotti ; Eidsmo, Liv ; Coquet, Jonathan M. ; Nylén, Susanne. / Intestinal helminth infection transforms the CD4+ T cell composition of the skin. In: Mucosal Immunology. 2022 ; Vol. 15. pp. 257–267.

Bibtex

@article{9bc5aecaffad4290a2c346effa1dc3a6,
title = "Intestinal helminth infection transforms the CD4+ T cell composition of the skin",
abstract = "Intestinal helminth parasites can alter immune responses to vaccines, other infections, allergens and autoantigens, implying effects on host immune responses in distal barrier tissues. We herein show that the skin of C57BL/6 mice infected with the strictly intestinal nematode Heligmosomoides polygyrus contain higher numbers of CD4+ T cells compared to the skin of uninfected controls. Accumulated CD4+ T cells were H. polygyrus-specific TH2 cells that skewed the skin CD4+ T cell composition towards a higher TH2/TH1 ratio which persisted after worm expulsion. Accumulation of TH2 cells in the skin was associated with increased expression of the skin-homing chemokine receptors CCR4 and CCR10 on CD4+ T cells in the blood and mesenteric lymph nodes draining the infected intestine and was abolished by FTY720 treatment during infection, indicating gut-to-skin trafficking of cells. Remarkably, skin TH2 accumulation was associated with impaired capacity to initiate IFN-γ recall responses and develop skin-resident memory cells to mycobacterial antigens, both during infection and months after deworming therapy. In conclusion, we show that infection by a strictly intestinal helminth has long-term effects on immune cell composition and local immune responses to unrelated antigens in the skin, revealing a novel process for T cell colonisation and worm-mediated immunosuppression in this organ. [Figure not available: see fulltext.].",
author = "Classon, {Cajsa H.} and Muzhen Li and Clavero, {Ada Lerma} and Junjie Ma and Xiaogang Feng and Tibbitt, {Christopher A.} and Stark, {Julian M.} and Rebeca Cardoso and Emma Ringqvist and Louis Boon and Villablanca, {Eduardo J.} and Rothfuchs, {Antonio Gigliotti} and Liv Eidsmo and Coquet, {Jonathan M.} and Susanne Nyl{\'e}n",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2022",
doi = "10.1038/s41385-021-00473-9",
language = "English",
volume = "15",
pages = "257–267",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Intestinal helminth infection transforms the CD4+ T cell composition of the skin

AU - Classon, Cajsa H.

AU - Li, Muzhen

AU - Clavero, Ada Lerma

AU - Ma, Junjie

AU - Feng, Xiaogang

AU - Tibbitt, Christopher A.

AU - Stark, Julian M.

AU - Cardoso, Rebeca

AU - Ringqvist, Emma

AU - Boon, Louis

AU - Villablanca, Eduardo J.

AU - Rothfuchs, Antonio Gigliotti

AU - Eidsmo, Liv

AU - Coquet, Jonathan M.

AU - Nylén, Susanne

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2022

Y1 - 2022

N2 - Intestinal helminth parasites can alter immune responses to vaccines, other infections, allergens and autoantigens, implying effects on host immune responses in distal barrier tissues. We herein show that the skin of C57BL/6 mice infected with the strictly intestinal nematode Heligmosomoides polygyrus contain higher numbers of CD4+ T cells compared to the skin of uninfected controls. Accumulated CD4+ T cells were H. polygyrus-specific TH2 cells that skewed the skin CD4+ T cell composition towards a higher TH2/TH1 ratio which persisted after worm expulsion. Accumulation of TH2 cells in the skin was associated with increased expression of the skin-homing chemokine receptors CCR4 and CCR10 on CD4+ T cells in the blood and mesenteric lymph nodes draining the infected intestine and was abolished by FTY720 treatment during infection, indicating gut-to-skin trafficking of cells. Remarkably, skin TH2 accumulation was associated with impaired capacity to initiate IFN-γ recall responses and develop skin-resident memory cells to mycobacterial antigens, both during infection and months after deworming therapy. In conclusion, we show that infection by a strictly intestinal helminth has long-term effects on immune cell composition and local immune responses to unrelated antigens in the skin, revealing a novel process for T cell colonisation and worm-mediated immunosuppression in this organ. [Figure not available: see fulltext.].

AB - Intestinal helminth parasites can alter immune responses to vaccines, other infections, allergens and autoantigens, implying effects on host immune responses in distal barrier tissues. We herein show that the skin of C57BL/6 mice infected with the strictly intestinal nematode Heligmosomoides polygyrus contain higher numbers of CD4+ T cells compared to the skin of uninfected controls. Accumulated CD4+ T cells were H. polygyrus-specific TH2 cells that skewed the skin CD4+ T cell composition towards a higher TH2/TH1 ratio which persisted after worm expulsion. Accumulation of TH2 cells in the skin was associated with increased expression of the skin-homing chemokine receptors CCR4 and CCR10 on CD4+ T cells in the blood and mesenteric lymph nodes draining the infected intestine and was abolished by FTY720 treatment during infection, indicating gut-to-skin trafficking of cells. Remarkably, skin TH2 accumulation was associated with impaired capacity to initiate IFN-γ recall responses and develop skin-resident memory cells to mycobacterial antigens, both during infection and months after deworming therapy. In conclusion, we show that infection by a strictly intestinal helminth has long-term effects on immune cell composition and local immune responses to unrelated antigens in the skin, revealing a novel process for T cell colonisation and worm-mediated immunosuppression in this organ. [Figure not available: see fulltext.].

U2 - 10.1038/s41385-021-00473-9

DO - 10.1038/s41385-021-00473-9

M3 - Journal article

C2 - 34931000

AN - SCOPUS:85121530202

VL - 15

SP - 257

EP - 267

JO - Mucosal Immunology

JF - Mucosal Immunology

SN - 1933-0219

ER -

ID: 288716395