Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

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Standard

Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. / Nielsen, M; Kaestel, C G; Eriksen, K W; Woetmann, A; Stokkedal, T; Kaltoft, K; Geisler, C; Röpke, C; Odum, N.

In: Leukemia, Vol. 13, No. 5, 1999, p. 735-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, M, Kaestel, CG, Eriksen, KW, Woetmann, A, Stokkedal, T, Kaltoft, K, Geisler, C, Röpke, C & Odum, N 1999, 'Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells', Leukemia, vol. 13, no. 5, pp. 735-8.

APA

Nielsen, M., Kaestel, C. G., Eriksen, K. W., Woetmann, A., Stokkedal, T., Kaltoft, K., Geisler, C., Röpke, C., & Odum, N. (1999). Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. Leukemia, 13(5), 735-8.

Vancouver

Nielsen M, Kaestel CG, Eriksen KW, Woetmann A, Stokkedal T, Kaltoft K et al. Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. Leukemia. 1999;13(5):735-8.

Author

Nielsen, M ; Kaestel, C G ; Eriksen, K W ; Woetmann, A ; Stokkedal, T ; Kaltoft, K ; Geisler, C ; Röpke, C ; Odum, N. / Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. In: Leukemia. 1999 ; Vol. 13, No. 5. pp. 735-8.

Bibtex

@article{258e3f20b0a311ddb538000ea68e967b,
title = "Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells",
abstract = "The Jak/Stat signaling pathway transmits signals from many cytokine and growth factor receptors to target genes in the nucleus. Constitutive activation of Stat3 has recently been observed in many tumor cells and dysregulation of the Stat signaling pathway has been proposed to be implicated in malignant transformation. In a previous study, we found constitutively tyrosine phosphorylated Stat3 in mycosis fungoides tumor cells. Here, we show that the Jak kinase inhibitor, Ag490, inhibits the constitutive binding of Stat3 to an oligonucleotide representing the Stat-binding sequence from the ICAM promotor. The decreased ability of Stat3 to bind DNA precedes dynamic alterations in the expression of anti-apoptotic Bcl-2 and pro-apoptotic Bax proteins (decreased Bcl-2 expression and increased Bax expression) and induction of apoptosis. Thus, our data suggest that the involvement of Stat3 in oncogenic transformation could be mediated through regulation of survival signals.",
author = "M Nielsen and Kaestel, {C G} and Eriksen, {K W} and A Woetmann and T Stokkedal and K Kaltoft and C Geisler and C R{\"o}pke and N Odum",
note = "Keywords: Animals; Apoptosis; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Mycosis Fungoides; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rabbits; STAT3 Transcription Factor; Skin Neoplasms; Trans-Activators; Tumor Cells, Cultured; Tyrphostins; bcl-2-Associated X Protein",
year = "1999",
language = "English",
volume = "13",
pages = "735--8",
journal = "Leukemia",
issn = "0887-6924",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

AU - Nielsen, M

AU - Kaestel, C G

AU - Eriksen, K W

AU - Woetmann, A

AU - Stokkedal, T

AU - Kaltoft, K

AU - Geisler, C

AU - Röpke, C

AU - Odum, N

N1 - Keywords: Animals; Apoptosis; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Mycosis Fungoides; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rabbits; STAT3 Transcription Factor; Skin Neoplasms; Trans-Activators; Tumor Cells, Cultured; Tyrphostins; bcl-2-Associated X Protein

PY - 1999

Y1 - 1999

N2 - The Jak/Stat signaling pathway transmits signals from many cytokine and growth factor receptors to target genes in the nucleus. Constitutive activation of Stat3 has recently been observed in many tumor cells and dysregulation of the Stat signaling pathway has been proposed to be implicated in malignant transformation. In a previous study, we found constitutively tyrosine phosphorylated Stat3 in mycosis fungoides tumor cells. Here, we show that the Jak kinase inhibitor, Ag490, inhibits the constitutive binding of Stat3 to an oligonucleotide representing the Stat-binding sequence from the ICAM promotor. The decreased ability of Stat3 to bind DNA precedes dynamic alterations in the expression of anti-apoptotic Bcl-2 and pro-apoptotic Bax proteins (decreased Bcl-2 expression and increased Bax expression) and induction of apoptosis. Thus, our data suggest that the involvement of Stat3 in oncogenic transformation could be mediated through regulation of survival signals.

AB - The Jak/Stat signaling pathway transmits signals from many cytokine and growth factor receptors to target genes in the nucleus. Constitutive activation of Stat3 has recently been observed in many tumor cells and dysregulation of the Stat signaling pathway has been proposed to be implicated in malignant transformation. In a previous study, we found constitutively tyrosine phosphorylated Stat3 in mycosis fungoides tumor cells. Here, we show that the Jak kinase inhibitor, Ag490, inhibits the constitutive binding of Stat3 to an oligonucleotide representing the Stat-binding sequence from the ICAM promotor. The decreased ability of Stat3 to bind DNA precedes dynamic alterations in the expression of anti-apoptotic Bcl-2 and pro-apoptotic Bax proteins (decreased Bcl-2 expression and increased Bax expression) and induction of apoptosis. Thus, our data suggest that the involvement of Stat3 in oncogenic transformation could be mediated through regulation of survival signals.

M3 - Journal article

C2 - 10374878

VL - 13

SP - 735

EP - 738

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 5

ER -

ID: 8545186