Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens

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Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens. / Bonefeld, Charlotte M.; Geisler, Carsten; Gimenéz-Arnau, Elena; Lepoittevin, Jean Pierre; Uter, Wolfgang; Johansen, Jeanne D.

In: Contact Dermatitis, Vol. 77, No. 3, 2017, p. 133-142.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bonefeld, CM, Geisler, C, Gimenéz-Arnau, E, Lepoittevin, JP, Uter, W & Johansen, JD 2017, 'Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens', Contact Dermatitis, vol. 77, no. 3, pp. 133-142. https://doi.org/10.1111/cod.12847

APA

Bonefeld, C. M., Geisler, C., Gimenéz-Arnau, E., Lepoittevin, J. P., Uter, W., & Johansen, J. D. (2017). Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens. Contact Dermatitis, 77(3), 133-142. https://doi.org/10.1111/cod.12847

Vancouver

Bonefeld CM, Geisler C, Gimenéz-Arnau E, Lepoittevin JP, Uter W, Johansen JD. Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens. Contact Dermatitis. 2017;77(3):133-142. https://doi.org/10.1111/cod.12847

Author

Bonefeld, Charlotte M. ; Geisler, Carsten ; Gimenéz-Arnau, Elena ; Lepoittevin, Jean Pierre ; Uter, Wolfgang ; Johansen, Jeanne D. / Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens. In: Contact Dermatitis. 2017 ; Vol. 77, No. 3. pp. 133-142.

Bibtex

@article{d864f647a1ba47039da2465f87ffe649,
title = "Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens",
abstract = "Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. In this article, we provide a general introduction to immune responses to contact allergens, and discuss the literature concerning immune responses to mixtures of allergens. According to the existing evidence, increased responses are induced following sensitization with combinations of allergens as compared with single allergens. The response to a mixture of allergens can be both additive and synergistic, depending on the dose and combination of allergens. Importantly, sensitization with combinations of either fragrance allergens or metal salts can result in increased challenge responses to specific allergens within the mixture. Taken together, the immune responses to mixtures of allergens are complex, and further studies are required to obtain the necessary knowledge to improve consumer safety.",
keywords = "fragrances, hair dyes, metals, mixtures of allergens",
author = "Bonefeld, {Charlotte M.} and Carsten Geisler and Elena Gimen{\'e}z-Arnau and Lepoittevin, {Jean Pierre} and Wolfgang Uter and Johansen, {Jeanne D.}",
year = "2017",
doi = "10.1111/cod.12847",
language = "English",
volume = "77",
pages = "133--142",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens

AU - Bonefeld, Charlotte M.

AU - Geisler, Carsten

AU - Gimenéz-Arnau, Elena

AU - Lepoittevin, Jean Pierre

AU - Uter, Wolfgang

AU - Johansen, Jeanne D.

PY - 2017

Y1 - 2017

N2 - Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. In this article, we provide a general introduction to immune responses to contact allergens, and discuss the literature concerning immune responses to mixtures of allergens. According to the existing evidence, increased responses are induced following sensitization with combinations of allergens as compared with single allergens. The response to a mixture of allergens can be both additive and synergistic, depending on the dose and combination of allergens. Importantly, sensitization with combinations of either fragrance allergens or metal salts can result in increased challenge responses to specific allergens within the mixture. Taken together, the immune responses to mixtures of allergens are complex, and further studies are required to obtain the necessary knowledge to improve consumer safety.

AB - Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. In this article, we provide a general introduction to immune responses to contact allergens, and discuss the literature concerning immune responses to mixtures of allergens. According to the existing evidence, increased responses are induced following sensitization with combinations of allergens as compared with single allergens. The response to a mixture of allergens can be both additive and synergistic, depending on the dose and combination of allergens. Importantly, sensitization with combinations of either fragrance allergens or metal salts can result in increased challenge responses to specific allergens within the mixture. Taken together, the immune responses to mixtures of allergens are complex, and further studies are required to obtain the necessary knowledge to improve consumer safety.

KW - fragrances

KW - hair dyes

KW - metals

KW - mixtures of allergens

U2 - 10.1111/cod.12847

DO - 10.1111/cod.12847

M3 - Review

C2 - 28677261

AN - SCOPUS:85021794573

VL - 77

SP - 133

EP - 142

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 3

ER -

ID: 182419216