Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes

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Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome : DNA polymorphism of HLA class II genes. / Morling, Niels; Andersen, V; Fugger, L; Georgsen, J; Halberg, P; Oxholm, P; Ødum, Niels; Svejgaard, A.

In: Disease Markers, Vol. 9, No. 5, 1992, p. 289-296.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Morling, N, Andersen, V, Fugger, L, Georgsen, J, Halberg, P, Oxholm, P, Ødum, N & Svejgaard, A 1992, 'Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes', Disease Markers, vol. 9, no. 5, pp. 289-296.

APA

Morling, N., Andersen, V., Fugger, L., Georgsen, J., Halberg, P., Oxholm, P., Ødum, N., & Svejgaard, A. (1992). Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes. Disease Markers, 9(5), 289-296.

Vancouver

Morling N, Andersen V, Fugger L, Georgsen J, Halberg P, Oxholm P et al. Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome: DNA polymorphism of HLA class II genes. Disease Markers. 1992;9(5):289-296.

Author

Morling, Niels ; Andersen, V ; Fugger, L ; Georgsen, J ; Halberg, P ; Oxholm, P ; Ødum, Niels ; Svejgaard, A. / Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome : DNA polymorphism of HLA class II genes. In: Disease Markers. 1992 ; Vol. 9, No. 5. pp. 289-296.

Bibtex

@article{222015c0fd9711ddb219000ea68e967b,
title = "Immunogenetics of rheumatoid arthritis and primary Sj{\"o}gren's syndrome: DNA polymorphism of HLA class II genes",
abstract = "We investigated the DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatability Complex (MHC) class II genes: HLA-DRB, -DQA, -DQB, DPA, and -DFB in 24 patients with rheumatoid arthritis (RA), in 19 patients with primary Sj{\"o}gren's syndrome (primary SS), and healthy Danes. The frequencies of DNA fragments associated with the following HLA class II genes were increased in RA when compared to normal controls: DRB1*04 (DR4) (relative risk, RR = 7.4, P less than 10(-3), DRB4*0101 (DRw53) (RR = 9.6, P less than 10(-3), DQA1*0301 (RR = 9.6, P less than 10(-3), DQB1*0301 (DQw7) (RR = 2.8, P less than 0.05, 'corrected' P greater than 0.05), and DQB1*0302 (DQw8) (RR = 4.5, P less than 10(-2). Negative associations were found between RA and DRB1*1501 (DR2/DRw15) (RR = 0.2, P less than 10(-2) and DQB1*0602 (DQw6) (RR = 0.2, P less than 10(-2), 'corrected' P greater than 0.05). The frequencies in RA of other HLA class II associated DNA fragments including DPA and DPB and the antigens DPw1-w6 defined by primed lymphocyte stimulation, did not differ significantly from those in controls. In primary SS, the frequency of HLA-B8 was significantly increased (RR = 9.0, P less than 10(-3). Positive associations were found between primary SS and DNA fragments associated with DRB1*03/13 (RR = 6.8, P less than 10(-3), DRB3*0101 (DRw52) (RR = 5.7, P less than 10(-2), DQA1*0501 (RR = 6.8, P less than 10(-3), DQB1*0201 (DQw2) (RR = 11.6, P less than 10(-5), and DQB1*0602 (DQw6) (RR = 2.7, P less than 0.05, 'corrected' P greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "Niels Morling and V Andersen and L Fugger and J Georgsen and P Halberg and P Oxholm and Niels {\O}dum and A Svejgaard",
note = "Keywords: Arthritis, Rheumatoid; Genes, MHC Class II; Genetic Markers; Humans; Polymorphism, Restriction Fragment Length; Sjogren's Syndrome",
year = "1992",
language = "English",
volume = "9",
pages = "289--296",
journal = "Disease Markers",
issn = "0278-0240",
publisher = "Hindawi Publishing Corporation",
number = "5",

}

RIS

TY - JOUR

T1 - Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome

T2 - DNA polymorphism of HLA class II genes

AU - Morling, Niels

AU - Andersen, V

AU - Fugger, L

AU - Georgsen, J

AU - Halberg, P

AU - Oxholm, P

AU - Ødum, Niels

AU - Svejgaard, A

N1 - Keywords: Arthritis, Rheumatoid; Genes, MHC Class II; Genetic Markers; Humans; Polymorphism, Restriction Fragment Length; Sjogren's Syndrome

PY - 1992

Y1 - 1992

N2 - We investigated the DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatability Complex (MHC) class II genes: HLA-DRB, -DQA, -DQB, DPA, and -DFB in 24 patients with rheumatoid arthritis (RA), in 19 patients with primary Sjögren's syndrome (primary SS), and healthy Danes. The frequencies of DNA fragments associated with the following HLA class II genes were increased in RA when compared to normal controls: DRB1*04 (DR4) (relative risk, RR = 7.4, P less than 10(-3), DRB4*0101 (DRw53) (RR = 9.6, P less than 10(-3), DQA1*0301 (RR = 9.6, P less than 10(-3), DQB1*0301 (DQw7) (RR = 2.8, P less than 0.05, 'corrected' P greater than 0.05), and DQB1*0302 (DQw8) (RR = 4.5, P less than 10(-2). Negative associations were found between RA and DRB1*1501 (DR2/DRw15) (RR = 0.2, P less than 10(-2) and DQB1*0602 (DQw6) (RR = 0.2, P less than 10(-2), 'corrected' P greater than 0.05). The frequencies in RA of other HLA class II associated DNA fragments including DPA and DPB and the antigens DPw1-w6 defined by primed lymphocyte stimulation, did not differ significantly from those in controls. In primary SS, the frequency of HLA-B8 was significantly increased (RR = 9.0, P less than 10(-3). Positive associations were found between primary SS and DNA fragments associated with DRB1*03/13 (RR = 6.8, P less than 10(-3), DRB3*0101 (DRw52) (RR = 5.7, P less than 10(-2), DQA1*0501 (RR = 6.8, P less than 10(-3), DQB1*0201 (DQw2) (RR = 11.6, P less than 10(-5), and DQB1*0602 (DQw6) (RR = 2.7, P less than 0.05, 'corrected' P greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

AB - We investigated the DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatability Complex (MHC) class II genes: HLA-DRB, -DQA, -DQB, DPA, and -DFB in 24 patients with rheumatoid arthritis (RA), in 19 patients with primary Sjögren's syndrome (primary SS), and healthy Danes. The frequencies of DNA fragments associated with the following HLA class II genes were increased in RA when compared to normal controls: DRB1*04 (DR4) (relative risk, RR = 7.4, P less than 10(-3), DRB4*0101 (DRw53) (RR = 9.6, P less than 10(-3), DQA1*0301 (RR = 9.6, P less than 10(-3), DQB1*0301 (DQw7) (RR = 2.8, P less than 0.05, 'corrected' P greater than 0.05), and DQB1*0302 (DQw8) (RR = 4.5, P less than 10(-2). Negative associations were found between RA and DRB1*1501 (DR2/DRw15) (RR = 0.2, P less than 10(-2) and DQB1*0602 (DQw6) (RR = 0.2, P less than 10(-2), 'corrected' P greater than 0.05). The frequencies in RA of other HLA class II associated DNA fragments including DPA and DPB and the antigens DPw1-w6 defined by primed lymphocyte stimulation, did not differ significantly from those in controls. In primary SS, the frequency of HLA-B8 was significantly increased (RR = 9.0, P less than 10(-3). Positive associations were found between primary SS and DNA fragments associated with DRB1*03/13 (RR = 6.8, P less than 10(-3), DRB3*0101 (DRw52) (RR = 5.7, P less than 10(-2), DQA1*0501 (RR = 6.8, P less than 10(-3), DQB1*0201 (DQw2) (RR = 11.6, P less than 10(-5), and DQB1*0602 (DQw6) (RR = 2.7, P less than 0.05, 'corrected' P greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

M3 - Journal article

C2 - 1686751

VL - 9

SP - 289

EP - 296

JO - Disease Markers

JF - Disease Markers

SN - 0278-0240

IS - 5

ER -

ID: 10636375