FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival
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FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival. / Gjerdrum, L M; Woetmann, A; Odum, Niels; Burton, C M; Rossen, K; Skovgaard, G L; Ryder, L P; Ralfkiaer, E.
In: Leukemia, Vol. 21, No. 12, 2007, p. 2512-2518.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival
AU - Gjerdrum, L M
AU - Woetmann, A
AU - Odum, Niels
AU - Burton, C M
AU - Rossen, K
AU - Skovgaard, G L
AU - Ryder, L P
AU - Ralfkiaer, E
N1 - Keywords: cutaneous T-cell lymphoma, FOXP3, immunohistochemistry, regulatory T cells, survival
PY - 2007
Y1 - 2007
N2 - FOXP3 is a unique marker for CD4+CD25+ regulatory T cells (Tregs). In solid tumours, high numbers of Tregs are associated with a poor prognosis. Knowledge about the implications of Tregs for the behaviour of haematological malignancies is limited. In this study, skin biopsies from 86 patients with mycosis fungoides (MF) and cutaneous T-cell lymphoma (CTCL) unspecified were analysed for the expression of FOXP3 on tumour cells and tumour-infiltrating Tregs. Labelling of above 10% of the neoplastic cells was seen in one case classified as an aggressive epidermotropic CD8+ cytotoxic CTCL. In the remaining 85 cases, the atypical neoplastic infiltrate was either FOXP3 negative (n=80) or contained only very occasional weakly positive cells (n=5). By contrast, all biopsies showed varying numbers of strongly FOXP3+ tumour-infiltrating Tregs. MF with early or infiltrated plaques had significantly higher numbers of FOXP3+ Tregs than CTCL unspecified or advanced MF with tumours or transformation to large cell lymphoma. An analysis of all patients demonstrated that increasing numbers of FOXP3+ Tregs were associated with improved survival in both MF and CTCL unspecified. In conclusion, our data indicate that the presence of FOXP3+ Tregs in CTCL is associated with disease stage and patient survival.
AB - FOXP3 is a unique marker for CD4+CD25+ regulatory T cells (Tregs). In solid tumours, high numbers of Tregs are associated with a poor prognosis. Knowledge about the implications of Tregs for the behaviour of haematological malignancies is limited. In this study, skin biopsies from 86 patients with mycosis fungoides (MF) and cutaneous T-cell lymphoma (CTCL) unspecified were analysed for the expression of FOXP3 on tumour cells and tumour-infiltrating Tregs. Labelling of above 10% of the neoplastic cells was seen in one case classified as an aggressive epidermotropic CD8+ cytotoxic CTCL. In the remaining 85 cases, the atypical neoplastic infiltrate was either FOXP3 negative (n=80) or contained only very occasional weakly positive cells (n=5). By contrast, all biopsies showed varying numbers of strongly FOXP3+ tumour-infiltrating Tregs. MF with early or infiltrated plaques had significantly higher numbers of FOXP3+ Tregs than CTCL unspecified or advanced MF with tumours or transformation to large cell lymphoma. An analysis of all patients demonstrated that increasing numbers of FOXP3+ Tregs were associated with improved survival in both MF and CTCL unspecified. In conclusion, our data indicate that the presence of FOXP3+ Tregs in CTCL is associated with disease stage and patient survival.
U2 - 10.1038/sj.leu.2404913
DO - 10.1038/sj.leu.2404913
M3 - Journal article
C2 - 17713545
VL - 21
SP - 2512
EP - 2518
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 12
ER -
ID: 10615041