Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma. / Willerslev-Olsen, Andreas; Krejsgaard, Thorbjørn; Lindahl, Lise Maria; Bonefeld, Charlotte Menne; Wasik, Mariusz A; Koralov, Sergei B; Geisler, Carsten; Kilian, Mogens; Iversen, Lars; Woetmann, Anders; Odum, Niels.

In: Toxins, Vol. 5, No. 8, 08.2013, p. 1402-21.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Willerslev-Olsen, A, Krejsgaard, T, Lindahl, LM, Bonefeld, CM, Wasik, MA, Koralov, SB, Geisler, C, Kilian, M, Iversen, L, Woetmann, A & Odum, N 2013, 'Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma', Toxins, vol. 5, no. 8, pp. 1402-21. https://doi.org/10.3390/toxins5081402

APA

Willerslev-Olsen, A., Krejsgaard, T., Lindahl, L. M., Bonefeld, C. M., Wasik, M. A., Koralov, S. B., Geisler, C., Kilian, M., Iversen, L., Woetmann, A., & Odum, N. (2013). Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma. Toxins, 5(8), 1402-21. https://doi.org/10.3390/toxins5081402

Vancouver

Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Bonefeld CM, Wasik MA, Koralov SB et al. Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma. Toxins. 2013 Aug;5(8):1402-21. https://doi.org/10.3390/toxins5081402

Author

Willerslev-Olsen, Andreas ; Krejsgaard, Thorbjørn ; Lindahl, Lise Maria ; Bonefeld, Charlotte Menne ; Wasik, Mariusz A ; Koralov, Sergei B ; Geisler, Carsten ; Kilian, Mogens ; Iversen, Lars ; Woetmann, Anders ; Odum, Niels. / Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma. In: Toxins. 2013 ; Vol. 5, No. 8. pp. 1402-21.

Bibtex

@article{64168c87bcda4e40810535fb47278331,
title = "Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma",
abstract = "In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.",
keywords = "Bacterial Infections, Bacterial Toxins, Cytokines, Disease Progression, Drug Resistance, Bacterial, Enterotoxins, Genes, T-Cell Receptor beta, Humans, Lymphoma, T-Cell, Cutaneous, Morbidity, Prevalence, Skin Neoplasms, Staphylococcus aureus, T-Lymphocytes",
author = "Andreas Willerslev-Olsen and Thorbj{\o}rn Krejsgaard and Lindahl, {Lise Maria} and Bonefeld, {Charlotte Menne} and Wasik, {Mariusz A} and Koralov, {Sergei B} and Carsten Geisler and Mogens Kilian and Lars Iversen and Anders Woetmann and Niels Odum",
year = "2013",
month = aug,
doi = "10.3390/toxins5081402",
language = "English",
volume = "5",
pages = "1402--21",
journal = "Toxins",
issn = "2072-6651",
publisher = "M D P I AG",
number = "8",

}

RIS

TY - JOUR

T1 - Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma

AU - Willerslev-Olsen, Andreas

AU - Krejsgaard, Thorbjørn

AU - Lindahl, Lise Maria

AU - Bonefeld, Charlotte Menne

AU - Wasik, Mariusz A

AU - Koralov, Sergei B

AU - Geisler, Carsten

AU - Kilian, Mogens

AU - Iversen, Lars

AU - Woetmann, Anders

AU - Odum, Niels

PY - 2013/8

Y1 - 2013/8

N2 - In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

AB - In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

KW - Bacterial Infections

KW - Bacterial Toxins

KW - Cytokines

KW - Disease Progression

KW - Drug Resistance, Bacterial

KW - Enterotoxins

KW - Genes, T-Cell Receptor beta

KW - Humans

KW - Lymphoma, T-Cell, Cutaneous

KW - Morbidity

KW - Prevalence

KW - Skin Neoplasms

KW - Staphylococcus aureus

KW - T-Lymphocytes

U2 - 10.3390/toxins5081402

DO - 10.3390/toxins5081402

M3 - Journal article

C2 - 23949004

VL - 5

SP - 1402

EP - 1421

JO - Toxins

JF - Toxins

SN - 2072-6651

IS - 8

ER -

ID: 106272614