Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. / Metzler, Veronika M.; de Brot, Simone; Robinson, Robert S.; Jeyapalan, Jennie N.; Rakha, Emad; Walton, Thomas; Gardner, David S.; Lund, Emma F.; Whitchurch, Jonathan; Haigh, Daisy; Lochray, Jack M.; Robinson, Brian D.; Allegrucci, Cinzia; Fray, Rupert G.; Persson, Jenny L.; Ødum, Niels; Miftakhova, Regina R.; Rizvanov, Albert A.; Hughes, Ieuan A.; Tadokoro-Cuccaro, Rieko; Heery, David M.; Rutland, Catrin S.; Mongan, Nigel P.

In: Placenta, Vol. 56, 2017, p. 79-85.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Metzler, VM, de Brot, S, Robinson, RS, Jeyapalan, JN, Rakha, E, Walton, T, Gardner, DS, Lund, EF, Whitchurch, J, Haigh, D, Lochray, JM, Robinson, BD, Allegrucci, C, Fray, RG, Persson, JL, Ødum, N, Miftakhova, RR, Rizvanov, AA, Hughes, IA, Tadokoro-Cuccaro, R, Heery, DM, Rutland, CS & Mongan, NP 2017, 'Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development', Placenta, vol. 56, pp. 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

APA

Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., Gardner, D. S., Lund, E. F., Whitchurch, J., Haigh, D., Lochray, J. M., Robinson, B. D., Allegrucci, C., Fray, R. G., Persson, J. L., Ødum, N., Miftakhova, R. R., Rizvanov, A. A., Hughes, I. A., ... Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

Vancouver

Metzler VM, de Brot S, Robinson RS, Jeyapalan JN, Rakha E, Walton T et al. Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta. 2017;56:79-85. https://doi.org/10.1016/j.placenta.2017.02.018

Author

Metzler, Veronika M. ; de Brot, Simone ; Robinson, Robert S. ; Jeyapalan, Jennie N. ; Rakha, Emad ; Walton, Thomas ; Gardner, David S. ; Lund, Emma F. ; Whitchurch, Jonathan ; Haigh, Daisy ; Lochray, Jack M. ; Robinson, Brian D. ; Allegrucci, Cinzia ; Fray, Rupert G. ; Persson, Jenny L. ; Ødum, Niels ; Miftakhova, Regina R. ; Rizvanov, Albert A. ; Hughes, Ieuan A. ; Tadokoro-Cuccaro, Rieko ; Heery, David M. ; Rutland, Catrin S. ; Mongan, Nigel P. / Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. In: Placenta. 2017 ; Vol. 56. pp. 79-85.

Bibtex

@article{eeea07f2903c4b5d9de7f98235c7a93a,
title = "Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development",
abstract = "The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy, whereas in tumors establishing new blood supplies is considered a key step in supporting metastases. Therefore the development of novel angiogenesis inhibitors has been an area of active research in oncology. A subset of the molecular processes regulating angiogenesis are well understood in the context of both early placentation and tumorigenesis. In this review we focus on the well-established role of androgen regulation of angiogenesis in cancer and relate these mechanisms to placental angiogenesis. The physiological actions of androgens are mediated by the androgen receptor (AR), a ligand dependent transcription factor. Androgens and the AR are essential for normal male embryonic development, puberty and lifelong health. Defects in androgen signalling are associated with a diverse range of clinical disorders in men and women including disorders of sex development (DSD), polycystic ovary syndrome in women and many cancers. We summarize the diverse molecular mechanisms of androgen regulation of angiogenesis and infer the potential significance of these pathways to normal and pathogenic placental function. Finally, we offer potential research applications of androgen-targeting molecules developed to treat cancer as investigative tools to help further delineate the role of androgen signalling in placental function and maternal and offspring health in animal models.",
keywords = "Angiogenesis, Epigenetics, Nuclear receptor, VEGF",
author = "Metzler, {Veronika M.} and {de Brot}, Simone and Robinson, {Robert S.} and Jeyapalan, {Jennie N.} and Emad Rakha and Thomas Walton and Gardner, {David S.} and Lund, {Emma F.} and Jonathan Whitchurch and Daisy Haigh and Lochray, {Jack M.} and Robinson, {Brian D.} and Cinzia Allegrucci and Fray, {Rupert G.} and Persson, {Jenny L.} and Niels {\O}dum and Miftakhova, {Regina R.} and Rizvanov, {Albert A.} and Hughes, {Ieuan A.} and Rieko Tadokoro-Cuccaro and Heery, {David M.} and Rutland, {Catrin S.} and Mongan, {Nigel P}",
year = "2017",
doi = "10.1016/j.placenta.2017.02.018",
language = "English",
volume = "56",
pages = "79--85",
journal = "Placenta",
issn = "0143-4004",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development

AU - Metzler, Veronika M.

AU - de Brot, Simone

AU - Robinson, Robert S.

AU - Jeyapalan, Jennie N.

AU - Rakha, Emad

AU - Walton, Thomas

AU - Gardner, David S.

AU - Lund, Emma F.

AU - Whitchurch, Jonathan

AU - Haigh, Daisy

AU - Lochray, Jack M.

AU - Robinson, Brian D.

AU - Allegrucci, Cinzia

AU - Fray, Rupert G.

AU - Persson, Jenny L.

AU - Ødum, Niels

AU - Miftakhova, Regina R.

AU - Rizvanov, Albert A.

AU - Hughes, Ieuan A.

AU - Tadokoro-Cuccaro, Rieko

AU - Heery, David M.

AU - Rutland, Catrin S.

AU - Mongan, Nigel P

PY - 2017

Y1 - 2017

N2 - The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy, whereas in tumors establishing new blood supplies is considered a key step in supporting metastases. Therefore the development of novel angiogenesis inhibitors has been an area of active research in oncology. A subset of the molecular processes regulating angiogenesis are well understood in the context of both early placentation and tumorigenesis. In this review we focus on the well-established role of androgen regulation of angiogenesis in cancer and relate these mechanisms to placental angiogenesis. The physiological actions of androgens are mediated by the androgen receptor (AR), a ligand dependent transcription factor. Androgens and the AR are essential for normal male embryonic development, puberty and lifelong health. Defects in androgen signalling are associated with a diverse range of clinical disorders in men and women including disorders of sex development (DSD), polycystic ovary syndrome in women and many cancers. We summarize the diverse molecular mechanisms of androgen regulation of angiogenesis and infer the potential significance of these pathways to normal and pathogenic placental function. Finally, we offer potential research applications of androgen-targeting molecules developed to treat cancer as investigative tools to help further delineate the role of androgen signalling in placental function and maternal and offspring health in animal models.

AB - The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy, whereas in tumors establishing new blood supplies is considered a key step in supporting metastases. Therefore the development of novel angiogenesis inhibitors has been an area of active research in oncology. A subset of the molecular processes regulating angiogenesis are well understood in the context of both early placentation and tumorigenesis. In this review we focus on the well-established role of androgen regulation of angiogenesis in cancer and relate these mechanisms to placental angiogenesis. The physiological actions of androgens are mediated by the androgen receptor (AR), a ligand dependent transcription factor. Androgens and the AR are essential for normal male embryonic development, puberty and lifelong health. Defects in androgen signalling are associated with a diverse range of clinical disorders in men and women including disorders of sex development (DSD), polycystic ovary syndrome in women and many cancers. We summarize the diverse molecular mechanisms of androgen regulation of angiogenesis and infer the potential significance of these pathways to normal and pathogenic placental function. Finally, we offer potential research applications of androgen-targeting molecules developed to treat cancer as investigative tools to help further delineate the role of androgen signalling in placental function and maternal and offspring health in animal models.

KW - Angiogenesis

KW - Epigenetics

KW - Nuclear receptor

KW - VEGF

U2 - 10.1016/j.placenta.2017.02.018

DO - 10.1016/j.placenta.2017.02.018

M3 - Journal article

C2 - 28238455

AN - SCOPUS:85013422177

VL - 56

SP - 79

EP - 85

JO - Placenta

JF - Placenta

SN - 0143-4004

ER -

ID: 178845623